Akitoshi Nakashima

h-index

Research activity per year

Campus career

医学科　助教　2007/04/01-2015/09/30
東西統合医学系　助教　2007/04/01-2015/09/30
附属病院　助教　2015/10/01-2016/01/31
附属病院　講師　2016/02/01-2019/09/30
附属病院　講師　2019/10/01-2020/01/31
医学系　講師　2019/10/01-2020/01/31
附属病院　教授　2020/02/01-
医学系　教授　2020/02/01-
医学部医学科　基幹教員
学部運営への参画状況・・・有-教授会他
担当授業科目に係る状況・・・主要授業科目担当

Research interests

The failure of autophagy impairs the placental development, resulting in poor placentation and hypertensive disorder of pregnancy (HDP). From the comparative study between HDP human and murine placentas, TFEB is involved in the regulation of placental autophagy.

Research Fields, Keywords

Obstetrics & Gynecology
Gynecologic cancer,
placenta
autophagy

Field of expertise (Grants-in-aid for Scientific Research classification)

Obstetrics and gynecology

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1 Similar Profiles

5 Active
6 Finished

妊娠高血圧症候群における胎盤オートファジー不全の臨床診断・治療法開発
Nakashima, A. (Principal Investigator)
Japan Society for the Promotion of Science
2026/04/01 → 2029/03/31
Project: Research Project
Rejuvenation of Oocytes through a Fundamental Understanding of Aging
Koike, S. (Principal Investigator), Nakashima, A. (Co-Investigator(Kenkyū-buntansha)), Oshima, Y. (Co-Investigator(Kenkyū-buntansha)) & Okada, T. (Co-Investigator(Kenkyū-buntansha))
Japan Society for the Promotion of Science
2025/04/01 → 2028/03/31
Project: Research Project
IFN and TNF signaling in preeclampsia; effects on T cell - trophoblast interactions
Tsuda, S. (Principal Investigator), Shima, T. (Co-Investigator(Kenkyū-buntansha)) & Nakashima, A. (Co-Investigator(Kenkyū-buntansha))
Japan Society for the Promotion of Science
2025/04/01 → 2028/03/31
Project: Research Project
Elucidation of the mechanisms of autophagy deficiency and maternal-fetal immune tolerance induction in pregnancy-induced hypertension nephropathy
Shima, T. (Principal Investigator), Nakashima, A. (Co-Investigator(Kenkyū-buntansha)) & Tsuda, S. (Co-Investigator(Kenkyū-buntansha))
Japan Society for the Promotion of Science
2025/04/01 → 2028/03/31
Project: Research Project
産科婦人科　中島彰俊　助教に対する研究助成
Nakashima, A. (PI)
2015/09/24 → …
Project: Research

79 Article
27 Review article
1 Comment/debate
1 Letter

Prediction Model of Hypertensive Disorders of Pregnancy Based on Home Blood Pressure Monitoring
Oku, M., Ohno, S., Metoki, H., Arai, E., Ito, M., Shiozaki, A., Nakashima, A., Iwama, N., Tsuchida, R., Yoneda, S., Yoneda, N., Tsuda, S., Satoh, M., Murakami, T., Tanigawara, S., Hoshi, K., Tanaka, K., Yamada, M. & Saito, S., 2026/03/03, In: Journal of the American Heart Association. 15, 5, p. e047093
Research output: Contribution to journal › Article › peer-review

Open Access
Differentiating uterine adenosarcoma from endometrial polyps: MRI imaging features
Harada, K., Kurata, Y., Himoto, Y., Kido, A., Kirita, M., Yoshida, A., Matsumoto, Y. K., Hamanishi, J., Minamiguchi, S., Ito, H., Nakashima, A., Minamisaka, T., Daido, S., Abiko, K., Moriyoshi, K., Ando, K., Arizono, S., Aoki, T., Hara, S. & Mandai, M. & 1 others, Nakamoto, Y., 2025/11, In: Abdominal Radiology. 50, 11, p. 5394-5404 11 p.
Research output: Contribution to journal › Article › peer-review
2 Link opens in a new tab Scopus citations
Interplay of Oxidative Stress, Autophagy, and Rubicon in Ovarian Follicle Dynamics: Orchestrating Ovarian Aging
Yamada, K., Ito, M., Nunomura, H., Nishigori, T., Furuta, A., Yoshida, M., Yamaki, A., Shozu, K., Yasuda, I., Tsuda, S., Shima, T. & Nakashima, A., 2025/08, In: Antioxidants. 14, 8, 919.
Research output: Contribution to journal › Review article › peer-review

Open Access
5 Link opens in a new tab Scopus citations
Novel Role of Pin1-Cis P-Tau-ApoE Axis in the Pathogenesis of Preeclampsia and Its Connection with Dementia
Amabebe, E., Huang, Z., Jash, S., Krishnan, B., Cheng, S., Nakashima, A., Li, Y., Li, Z., Wang, R., Menon, R., Zhou, X. Z., Lu, K. P. & Sharma, S., 2025/01, In: Biomedicines. 13, 1, 29.
Research output: Contribution to journal › Review article › peer-review

Open Access
2 Link opens in a new tab Scopus citations
Remission of intercellular IgG/IgA dermatosis after treatment for cervical cancer
Kitayama, S., Takemoto, K., Matsui, Y., Makino, T., Mizawa, M., Shima, T., Nakashima, A., Ishii, N., Hashimoto, T. & Shimizu, T., 2025/03, In: Journal of Dermatology. 52, 3, p. e218-e219
Research output: Contribution to journal › Letter › peer-review

Silver nanoparticles suppress forskolin-induced syncytialization in BeWo cells
Sakahashi, Y. (Creator), Higashisaka, K. (Creator), Isaka, R. (Creator), Izutani, R. (Creator), Seo, J. (Creator), Furuta, A. (Creator), Yamaki-Ushijima, A. (Creator), Tsujino, H. (Creator), Haga, Y. (Creator), Nakashima, A. (Creator) & Tsutsumi, Y. (Creator), Taylor & Francis, 2023
DOI: 10.6084/m9.figshare.21807000, https://tandf.figshare.com/articles/presentation/Silver_nanoparticles_suppress_forskolin-induced_syncytialization_in_BeWo_cells/21807000
Dataset
Evidence for lysosomal biogenesis proteome defect and impaired autophagy in preeclampsia
Nakashima, A. (Creator), Cheng, S.-B. (Creator), Ikawa, M. (Creator), Yoshimori, T. (Creator), Huber, W. J. (Creator), Menon, R. (Contributor), Huang, Z. (Contributor), Fierce, J. (Creator), Padbury, J. F. (Creator), Sadovsky, Y. (Creator), Saito, S. (Creator) & Sharma, S. (Contributor), Taylor & Francis, 2019
DOI: 10.6084/m9.figshare.11416755.v1, https://tandf.figshare.com/articles/dataset/Evidence_for_lysosomal_biogenesis_proteome_defect_and_impaired_autophagy_in_preeclampsia/11416755/1
Dataset
supplemental_figure_2 - Sphingosine 1 Phosphate (S1P) Increased IL-6 Expression and Cell Growth in Endometriotic Cells
Yoshino, O. (Creator), Yamada-Nomoto, K. (Creator), Kano, K. (Contributor), Ono, Y. (Creator), Kobayashi, M. (Creator), Ito, M. (Creator), Yoneda, S. (Creator), Nakashima, A. (Creator), Shima, T. (Creator), Onda, T. (Creator), Osuga, Y. (Creator), Aoki, J. (Contributor) & Saito, S. (Creator), SAGE Journals, 2019
DOI: 10.25384/sage.7751576.v1, https://sage.figshare.com/articles/supplemental_figure_2_-_Sphingosine_1_Phosphate_S1P_Increased_IL-6_Expression_and_Cell_Growth_in_Endometriotic_Cells/7751576/1
Dataset
Supplemental_figure_1 - Sphingosine 1 Phosphate (S1P) Increased IL-6 Expression and Cell Growth in Endometriotic Cells
Yoshino, O. (Creator), Yamada-Nomoto, K. (Creator), Kano, K. (Contributor), Ono, Y. (Creator), Kobayashi, M. (Creator), Ito, M. (Creator), Yoneda, S. (Creator), Nakashima, A. (Creator), Shima, T. (Creator), Onda, T. (Creator), Osuga, Y. (Creator), Aoki, J. (Contributor) & Saito, S. (Creator), SAGE Journals, 2019
DOI: 10.25384/sage.7751573, https://sage.figshare.com/articles/Supplemental_figure_1_-_Sphingosine_1_Phosphate_S1P_Increased_IL-6_Expression_and_Cell_Growth_in_Endometriotic_Cells/7751573
Dataset
Supplemental_figure_1 - Sphingosine 1 Phosphate (S1P) Increased IL-6 Expression and Cell Growth in Endometriotic Cells
Yoshino, O. (Creator), Yamada-Nomoto, K. (Creator), Kano, K. (Contributor), Ono, Y. (Creator), Kobayashi, M. (Creator), Ito, M. (Creator), Yoneda, S. (Creator), Nakashima, A. (Creator), Shima, T. (Creator), Onda, T. (Creator), Osuga, Y. (Creator), Aoki, J. (Contributor) & Saito, S. (Creator), SAGE Journals, 2019
DOI: 10.25384/sage.7751573.v1, https://sage.figshare.com/articles/Supplemental_figure_1_-_Sphingosine_1_Phosphate_S1P_Increased_IL-6_Expression_and_Cell_Growth_in_Endometriotic_Cells/7751573/1
Dataset

学術奨励賞
Nakashima, A. (Recipient), 2020/04
Prize
学会賞
Nakashima, A. (Recipient), 2017/12
Prize
International session Best Award
Nakashima, A. (Recipient), 2016/04
Prize
Travel Award
Nakashima, A. (Recipient), 2015/06
Prize
Poster presentation award
Nakashima, A. (Recipient), 2014/06
Prize

Symposium “Pathophysiology of PE” The role of autophagy in pathophysiology of PE.
Nakashima, A. (Speaker)
2021/09/15 → 2021/09/28
Activity: Talk or presentation › Oral presentation
教育講演　オートファジーと妊娠高血圧症候群 (Hypertensive disorders of pregnancy, HDP).
Nakashima, A. (Speaker)
2021/04/22 → 2021/05/07
Activity: Talk or presentation › Oral presentation
オートファジー破綻は妊娠高血圧腎症胎盤におけるトランスサイレチン蓄積に関与する．
Nakashima, A. (Speaker)
2017/03/04
Activity: Talk or presentation › Oral presentation
“Preeclampsia serum disrupts the autophagy/lysosome pathway cooperated with endoplasmic reticulum (ER) stress“
Nakashima, A. (Speaker)
2016/12/05 → 2016/12/08
Activity: Talk or presentation › Oral presentation
シンポジウム1”トロホブラスト・リサーチCurrent Topics and Future Goals” 妊娠高血圧腎症患者血清は小胞体ストレスと共に絨毛細胞のオートファジーを破綻させる．
Nakashima, A. (Speaker)
2016/11/25 → 2016/11/26
Activity: Talk or presentation › Oral presentation

高度先進医療実践学特論
Yoshimura, N., Hayashi, R., Nakashima, A., Tsuchiya, T., Kitamura, H., Fujii, T., Satake, T. & Doi, T.
2024/12/04 → 2025/03/31
Course
生殖系
Fujiuchi, Y., Nakashima, A., Ito, M., Takemura, K., Kitamura, H., Shima, T., Saitoh, J.-I., Okabe, M. & Watanabe, A.
2024/10/01 → 2025/03/31
Course
胎児・周産期医学特論Ⅰ
Nakashima, A.
2024/10/01 → 2025/03/31
Course
産科婦人科学特論
Nakashima, A. & Yoneda, S.
2024/10/01 → 2025/03/31
Course
妊娠と分娩
Nakashima, A., Shozu, K., Yoneda, S., Shiozaki, A., Yoneda, N., Shima, T., Ito, M. & Tsuda, S.
2024/04/01 → 2024/09/30
Course

Akitoshi Nakashima

Personal profile

Campus career

Research interests

Research Fields, Keywords

Field of expertise (Grants-in-aid for Scientific Research classification)

Fingerprint

Collaborations and top research areas from the last five years

Dive into details

妊娠高血圧症候群における胎盤オートファジー不全の臨床診断・治療法開発

Rejuvenation of Oocytes through a Fundamental Understanding of Aging

IFN and TNF signaling in preeclampsia; effects on T cell - trophoblast interactions

Elucidation of the mechanisms of autophagy deficiency and maternal-fetal immune tolerance induction in pregnancy-induced hypertension nephropathy

産科婦人科　中島彰俊　助教に対する研究助成

Prediction Model of Hypertensive Disorders of Pregnancy Based on Home Blood Pressure Monitoring

Differentiating uterine adenosarcoma from endometrial polyps: MRI imaging features

Interplay of Oxidative Stress, Autophagy, and Rubicon in Ovarian Follicle Dynamics: Orchestrating Ovarian Aging

Novel Role of Pin1-Cis P-Tau-ApoE Axis in the Pathogenesis of Preeclampsia and Its Connection with Dementia

Remission of intercellular IgG/IgA dermatosis after treatment for cervical cancer

Silver nanoparticles suppress forskolin-induced syncytialization in BeWo cells

Evidence for lysosomal biogenesis proteome defect and impaired autophagy in preeclampsia

supplemental_figure_2 - Sphingosine 1 Phosphate (S1P) Increased IL-6 Expression and Cell Growth in Endometriotic Cells

Supplemental_figure_1 - Sphingosine 1 Phosphate (S1P) Increased IL-6 Expression and Cell Growth in Endometriotic Cells

Supplemental_figure_1 - Sphingosine 1 Phosphate (S1P) Increased IL-6 Expression and Cell Growth in Endometriotic Cells

学術奨励賞

学会賞

International session Best Award

Travel Award

Poster presentation award

Symposium “Pathophysiology of PE” The role of autophagy in pathophysiology of PE.

教育講演　オートファジーと妊娠高血圧症候群 (Hypertensive disorders of pregnancy, HDP).

オートファジー破綻は妊娠高血圧腎症胎盤におけるトランスサイレチン蓄積に関与する．

“Preeclampsia serum disrupts the autophagy/lysosome pathway cooperated with endoplasmic reticulum (ER) stress“

シンポジウム1”トロホブラスト・リサーチCurrent Topics and Future Goals” 妊娠高血圧腎症患者血清は小胞体ストレスと共に絨毛細胞のオートファジーを破綻させる．

高度先進医療実践学特論

生殖系

胎児・周産期医学特論Ⅰ

産科婦人科学特論

妊娠と分娩

Akitoshi Nakashima

Personal profile

Campus career

Research interests

Research Fields, Keywords

Field of expertise (Grants-in-aid for Scientific Research classification)

Fingerprint

Collaborations and top research areas from the last five years

Projects

Research output

Datasets

Prizes

Activities

Courses