TY - JOUR
T1 - Three neo-Clerodane Diterpenoids from Tinospora cordifolia Stems and Their Arginase Inhibitory Activities
AU - Hoang, Nhat Nam
AU - Hoshino, Shotaro
AU - Kodama, Takeshi
AU - Nakashima, Yu
AU - Do, Kiep Minh
AU - Thao, Hoang Xuan
AU - Ikumi, Naotaka
AU - Onaka, Hiroyasu
AU - Morita, Hiroyuki
N1 - Publisher Copyright:
© 2024 Author(s).
PY - 2024/6
Y1 - 2024/6
N2 - Three neo-clerodane diterpenoids, including two new tinocordifoliols A (1) and B (2) and one known tinopanoid R (3), were isolated from the ethyl acetate-soluble fraction of the 70% ethanol extract of Tinospora cordifolia stems. The structures were elucidated by various spectroscopic methods, including one dimensional (1D) and 2D-NMR, high resolution-electrospray ionization (HR-ESI)-MS, and electronic circular dichroism (ECD) data. The T. cordifolia extract and all isolated compounds 1-3 possessed arginase I inhibitory activities. Among them, 3 exhibited moderate competitive inhibition of human arginase I (IC50 = 61.9 μM). Furthermore, docking studies revealed that the presence of a β-substituted furan in 3 may play a key role in the arginase I inhibitory activities.
AB - Three neo-clerodane diterpenoids, including two new tinocordifoliols A (1) and B (2) and one known tinopanoid R (3), were isolated from the ethyl acetate-soluble fraction of the 70% ethanol extract of Tinospora cordifolia stems. The structures were elucidated by various spectroscopic methods, including one dimensional (1D) and 2D-NMR, high resolution-electrospray ionization (HR-ESI)-MS, and electronic circular dichroism (ECD) data. The T. cordifolia extract and all isolated compounds 1-3 possessed arginase I inhibitory activities. Among them, 3 exhibited moderate competitive inhibition of human arginase I (IC50 = 61.9 μM). Furthermore, docking studies revealed that the presence of a β-substituted furan in 3 may play a key role in the arginase I inhibitory activities.
KW - arginase inhibitory activity
KW - clerodane diterpenoid
KW - neo-clerodane diterpenoid
KW - Tinospora cordifolia
UR - http://www.scopus.com/inward/record.url?scp=85195788571&partnerID=8YFLogxK
U2 - 10.1248/cpb.c24-00240
DO - 10.1248/cpb.c24-00240
M3 - 学術論文
C2 - 38866475
AN - SCOPUS:85195788571
SN - 0009-2363
VL - 72
SP - 540
EP - 546
JO - Chemical and Pharmaceutical Bulletin
JF - Chemical and Pharmaceutical Bulletin
IS - 6
ER -