Serum neurofilament light chain in chronic inflammatory demyelinating polyneuropathy

Tomohiro Hayashi, Takamasa Nukui, Jin Lan Piao, Tomoyuki Sugimoto, Ryoko Anada, Noriyuki Matsuda, Mamoru Yamamoto, Hirofumi Konishi, Nobuhiro Dougu, Yuji Nakatsuji*

*この論文の責任著者

研究成果: ジャーナルへの寄稿学術論文査読

31 被引用数 (Scopus)

抄録

Objectives: Neurofilament light chain (NfL) levels have been suggested as reflecting axonal damage in various inflammatory and neurodegenerative disorders, including acquired peripheral neuropathies. We aimed to investigate if serum NfL (sNfL) levels can be a biomarker of disease activity and treatment response in patients with chronic inflammatory demyelinating polyneuropathy (CIDP). Materials and methods: The sNfL levels of eleven newly diagnosed patients with CIDP were retrospectively assayed and compared with seven healthy volunteers. The levels were assayed before and after intravenous immunoglobulin treatment in patients with CIDP and were also assayed in the remission period. Results: Baseline sNfL levels in patients with CIDP before treatment were significantly higher than those in healthy controls. The levels significantly decreased overtime after one month of treatment and in remission period. There were significant negative correlations between the sNfL levels and the disease duration (the interval between the onset of the disease and the time of sampling), and weak correlations between the sNfL levels and overall neuropathy limitations scale. Conclusions: sNfL may be a potential biomarker reflecting the disease activity in patients with CIDP.

本文言語英語
論文番号e02084
ジャーナルBrain and Behavior
11
5
DOI
出版ステータス出版済み - 2021/05

ASJC Scopus 主題領域

  • 行動神経科学

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