TY - CHAP
T1 - Regulatory T cells
T2 - Master regulators for the success of pregnancy
AU - Tsuda, Sayaka
AU - Saito, Shigeru
N1 - Publisher Copyright:
© 2021 Elsevier Inc. All rights reserved.
PY - 2021/1/1
Y1 - 2021/1/1
N2 - Regulatory T cells (Treg cells) are an immunosuppressive subset of helper T cells, which are crucial to maintaining immune homeostasis, self-tolerance, and feto-maternal tolerance. Fetal alloantigens are recognized by conventional T cells; however, Treg cells, directly and indirectly, suppress their cytotoxic activities against fetuses. Murine models show that paternal antigen-specific Treg cells (PA-Treg cells) expand at the feto-maternal interface during pregnancies and seminal plasma-priming is important to this process. In humans, extensive epidemiological data of preeclampsia suggest that insufficient PA-specific tolerance relates to its development, but some epidemiological studies suggest the relationship between PA-specific tolerance and miscarriages. Recent basic research studies imply the immunological differences between miscarriages and preeclampsia from the standpoint of PA-Treg cells, which support epidemiological evidence. In this section, we review the latest understanding of Treg cell-mediated tolerance and prospects of clinical applications of immunological therapies and preventions for miscarriages and preeclampsia.
AB - Regulatory T cells (Treg cells) are an immunosuppressive subset of helper T cells, which are crucial to maintaining immune homeostasis, self-tolerance, and feto-maternal tolerance. Fetal alloantigens are recognized by conventional T cells; however, Treg cells, directly and indirectly, suppress their cytotoxic activities against fetuses. Murine models show that paternal antigen-specific Treg cells (PA-Treg cells) expand at the feto-maternal interface during pregnancies and seminal plasma-priming is important to this process. In humans, extensive epidemiological data of preeclampsia suggest that insufficient PA-specific tolerance relates to its development, but some epidemiological studies suggest the relationship between PA-specific tolerance and miscarriages. Recent basic research studies imply the immunological differences between miscarriages and preeclampsia from the standpoint of PA-Treg cells, which support epidemiological evidence. In this section, we review the latest understanding of Treg cell-mediated tolerance and prospects of clinical applications of immunological therapies and preventions for miscarriages and preeclampsia.
KW - Alloantigen
KW - Effector treg cell
KW - Miscarriage
KW - Naturally occurring treg cell
KW - Peripherally induced treg cell
KW - Preeclampsia
KW - Regulatory T cell
UR - http://www.scopus.com/inward/record.url?scp=85126415828&partnerID=8YFLogxK
U2 - 10.1016/B978-0-12-818508-7.00015-4
DO - 10.1016/B978-0-12-818508-7.00015-4
M3 - 章
AN - SCOPUS:85126415828
SP - 115
EP - 127
BT - Reproductive Immunology
PB - Elsevier
ER -