Regulatory T cells: Master regulators for the success of pregnancy

研究成果: 書籍の章/レポート/会議録査読

抄録

Regulatory T cells (Treg cells) are an immunosuppressive subset of helper T cells, which are crucial to maintaining immune homeostasis, self-tolerance, and feto-maternal tolerance. Fetal alloantigens are recognized by conventional T cells; however, Treg cells, directly and indirectly, suppress their cytotoxic activities against fetuses. Murine models show that paternal antigen-specific Treg cells (PA-Treg cells) expand at the feto-maternal interface during pregnancies and seminal plasma-priming is important to this process. In humans, extensive epidemiological data of preeclampsia suggest that insufficient PA-specific tolerance relates to its development, but some epidemiological studies suggest the relationship between PA-specific tolerance and miscarriages. Recent basic research studies imply the immunological differences between miscarriages and preeclampsia from the standpoint of PA-Treg cells, which support epidemiological evidence. In this section, we review the latest understanding of Treg cell-mediated tolerance and prospects of clinical applications of immunological therapies and preventions for miscarriages and preeclampsia.

本文言語英語
ホスト出版物のタイトルReproductive Immunology
ホスト出版物のサブタイトルBasic Concepts
出版社Elsevier
ページ115-127
ページ数13
ISBN(電子版)9780128185087
DOI
出版ステータス出版済み - 2021/01/01

ASJC Scopus 主題領域

  • 医学一般
  • 免疫学および微生物学一般

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