TY - JOUR
T1 - Recent Advances in the Synthesis of Benzothiazole and its Derivatives
AU - Qadir, Tanzeela
AU - Amin, Andleeb
AU - Salhotra, Alka
AU - Sharma, Praveen Kumar
AU - Jeelani, Ishtiaq
AU - Abe, Hitoshi
N1 - Publisher Copyright:
© 2022 Bentham Science Publishers.
PY - 2022/1
Y1 - 2022/1
N2 - Benzothiazoles have recognized pharmacophores in the field of research, predominantly in synthetic and medicinal chemistry, on account of their significant pharmaceutical properties. This important class of derivatives endows an extensive range of biological activities like anti-inflammatory, antidiabetic, anticancer, anticonvulsant, antibacterial, antiviral, antioxidant, antituberculosis, enzyme inhibitors, etc. Hence, various methodologies have been accomplished to synthesize benzothiazole compounds considering the purity, yield, and selectivity of the products. This review provides different reaction methods that are involved in the synthesis of a variety of benzothiazole derivatives.
AB - Benzothiazoles have recognized pharmacophores in the field of research, predominantly in synthetic and medicinal chemistry, on account of their significant pharmaceutical properties. This important class of derivatives endows an extensive range of biological activities like anti-inflammatory, antidiabetic, anticancer, anticonvulsant, antibacterial, antiviral, antioxidant, antituberculosis, enzyme inhibitors, etc. Hence, various methodologies have been accomplished to synthesize benzothiazole compounds considering the purity, yield, and selectivity of the products. This review provides different reaction methods that are involved in the synthesis of a variety of benzothiazole derivatives.
KW - 2-aminothiophenol
KW - Aldehydes
KW - Benzothiazoles
KW - Condensation
KW - Cyclization
KW - Green chemistry
KW - Nitriles
KW - Thioamides
UR - http://www.scopus.com/inward/record.url?scp=85125318785&partnerID=8YFLogxK
U2 - 10.2174/1385272826666211229144446
DO - 10.2174/1385272826666211229144446
M3 - 総説
AN - SCOPUS:85125318785
SN - 1385-2728
VL - 26
SP - 189
EP - 214
JO - Current Organic Chemistry
JF - Current Organic Chemistry
IS - 2
ER -