Pyrrolactams from marine sponge stylissa massa collected from myanmar and their anti-vpr activities

Nwet Nwet Win; Takeshi Kodama; Aung Aung Aye; Khine Zar Wynn Lae; Hla Ngwe; Nang Mya Han; Ikuro Abe; Hiroyuki Morita

doi:10.1248/cpb.c21-00227

Pyrrolactams from marine sponge stylissa massa collected from myanmar and their anti-vpr activities

Nwet Nwet Win, Takeshi Kodama, Aung Aung Aye, Khine Zar Wynn Lae, Hla Ngwe, Nang Mya Han, Ikuro Abe, Hiroyuki Morita^*

^*この論文の責任著者

和漢医薬学総合研究所研究開発部門資源開発分野（天然物創薬学領域）

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

4 被引用数 (Scopus)

抄録

A new brominated pyrrolactam stylissaol A (1) together with four known analogues, 2-bromoaldisine, aldisine, spongiacidin D, and Z-hymenialdisine, were isolated from the EtOAc extract of marine sponge Stylissa massa collected in Myanmar. The absolute configuration at C-10 of 1 was determined as R by the electronic circular dichroism (ECD) data. Among the isolated compounds, 2-bromoaldisine showed anti-Viral Protein R (Vpr) activity against TREx-HeLa-Vpr cells with an effective dose of 10 μM and its potency was comparable to that of positive control damnacanthal.

本文言語	英語
ページ（範囲）	702-705
ページ数	4
ジャーナル	Chemical and Pharmaceutical Bulletin
巻	69
号	7
DOI	https://doi.org/10.1248/cpb.c21-00227
出版ステータス	出版済み - 2021/07/01

ASJC Scopus 主題領域

化学一般
創薬

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10.1248/cpb.c21-00227

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title = "Pyrrolactams from marine sponge stylissa massa collected from myanmar and their anti-vpr activities",

abstract = "A new brominated pyrrolactam stylissaol A (1) together with four known analogues, 2-bromoaldisine, aldisine, spongiacidin D, and Z-hymenialdisine, were isolated from the EtOAc extract of marine sponge Stylissa massa collected in Myanmar. The absolute configuration at C-10 of 1 was determined as R by the electronic circular dichroism (ECD) data. Among the isolated compounds, 2-bromoaldisine showed anti-Viral Protein R (Vpr) activity against TREx-HeLa-Vpr cells with an effective dose of 10 μM and its potency was comparable to that of positive control damnacanthal.",

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author = "Win, {Nwet Nwet} and Takeshi Kodama and Aye, {Aung Aung} and Lae, {Khine Zar Wynn} and Hla Ngwe and Han, {Nang Mya} and Ikuro Abe and Hiroyuki Morita",

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doi = "10.1248/cpb.c21-00227",

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AU - Win, Nwet Nwet

AU - Kodama, Takeshi

AU - Aye, Aung Aung

AU - Lae, Khine Zar Wynn

AU - Ngwe, Hla

AU - Han, Nang Mya

AU - Abe, Ikuro

AU - Morita, Hiroyuki

PY - 2021/7/1

Y1 - 2021/7/1

N2 - A new brominated pyrrolactam stylissaol A (1) together with four known analogues, 2-bromoaldisine, aldisine, spongiacidin D, and Z-hymenialdisine, were isolated from the EtOAc extract of marine sponge Stylissa massa collected in Myanmar. The absolute configuration at C-10 of 1 was determined as R by the electronic circular dichroism (ECD) data. Among the isolated compounds, 2-bromoaldisine showed anti-Viral Protein R (Vpr) activity against TREx-HeLa-Vpr cells with an effective dose of 10 μM and its potency was comparable to that of positive control damnacanthal.

AB - A new brominated pyrrolactam stylissaol A (1) together with four known analogues, 2-bromoaldisine, aldisine, spongiacidin D, and Z-hymenialdisine, were isolated from the EtOAc extract of marine sponge Stylissa massa collected in Myanmar. The absolute configuration at C-10 of 1 was determined as R by the electronic circular dichroism (ECD) data. Among the isolated compounds, 2-bromoaldisine showed anti-Viral Protein R (Vpr) activity against TREx-HeLa-Vpr cells with an effective dose of 10 μM and its potency was comparable to that of positive control damnacanthal.

KW - Pyrrolactam

KW - Stylissa massa

KW - Stylissaol A

KW - TREx-HeLa-Viral protein R (Vpr)

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U2 - 10.1248/cpb.c21-00227

DO - 10.1248/cpb.c21-00227

M3 - 学術論文

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SN - 0009-2363

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SP - 702

EP - 705

JO - Chemical and Pharmaceutical Bulletin

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Pyrrolactams from marine sponge stylissa massa collected from myanmar and their anti-vpr activities

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