Ionizing radiation enhances Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL)-induced apoptosis through up-regulations of Death Receptor 4 (DR4) and Death Receptor 5 (DR5) in human osteosarcoma cells

Takeshi Hori, Takashi Kondo*, Masahiko Kanamori, Yoshiaki Tabuchi, Ryohei Ogawa, Qing Li Zhao, Kanwal Ahmed, Taketoshi Yasuda, Shoji Seki, Kayo Suzuki, Tomoatsu Kimura

*この論文の責任著者

研究成果: ジャーナルへの寄稿学術論文査読

23 被引用数 (Scopus)

抄録

Despite improvements in chemotherapy and surgery in the treatment of osteosarcoma (OS), satisfactory results are still difficult to achieve. Novel therapeutic modalities need to be developed for osteosarcoma treatment. The combined effects of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and ionizing radiation (IR) on human OS cells were investigated. IR and TRAIL treatment synergistically decreased the cell viability and enhanced apoptosis in OS cell lines. IR pretreatment enhances TRAIL-induced Bid and caspase-3 activations. Decreases in the expression levels of the antiapoptotic proteins c-FLIP and XIAP also associated with apoptosis enhancement. Furthermore, IR pretreatment enhanced DR4 and DR5 expressions at the transcription stage. These results can become the basic lines of evidence for the future treatment of OS using TRAIL with IR.

本文言語英語
ページ(範囲)739-745
ページ数7
ジャーナルJournal of Orthopaedic Research
28
6
DOI
出版ステータス出版済み - 2010/06

ASJC Scopus 主題領域

  • 整形外科およびスポーツ医学

フィンガープリント

「Ionizing radiation enhances Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL)-induced apoptosis through up-regulations of Death Receptor 4 (DR4) and Death Receptor 5 (DR5) in human osteosarcoma cells」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

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