Identification of double-stranded DNA in the cerebrospinal fluid of patients with acute neuromyelitis optica spectrum disorder

Mamoru Yamamoto; Tatsusada Okuno; Jin Lan Piao; Mikito Shimizu; Katsuichi Miyamoto; Takamasa Nukui; Makoto Kinoshita; Toru Koda; Ratna Dini Haryuni; Hideki Mochizuki; Tomoyuki Sugimoto; Yuji Nakatsuji

doi:10.1016/j.jocn.2022.12.005

Identification of double-stranded DNA in the cerebrospinal fluid of patients with acute neuromyelitis optica spectrum disorder

Mamoru Yamamoto, Tatsusada Okuno^*, Jin Lan Piao, Mikito Shimizu, Katsuichi Miyamoto, Takamasa Nukui, Makoto Kinoshita, Toru Koda, Ratna Dini Haryuni, Hideki Mochizuki, Tomoyuki Sugimoto, Yuji Nakatsuji

^*この論文の責任著者

脳神経内科（神経内科）

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

抄録

Neuromyelitis optica spectrum disorder (NMOSD) is an inflammatory disease of the central nervous system (CNS) characterized by severe myelitis and optic neuritis. Double-stranded DNA (dsDNA) is involved in the pathogenesis of various autoimmune diseases, such as systemic lupus erythematosus. However, its role in NMOSD remains unclear. In this study, the concentration of dsDNA in the cerebrospinal fluid (CSF) was quantified in 23 patients with NMOSD and 16 patients with other neurological diseases (ONDs). CSF dsDNA levels in patients with NMOSD (median: 0.03 ng/µL) were significantly higher than those in patients with ONDs (median: 0.01 ng/μl). CSF dsDNA levels showed no significant difference before and after treatment. Elevation of CSF dsDNA levels may suggest its essential role in the augmentation of CNS inflammation in patients with NMOSD.

本文言語	英語
ページ（範囲）	129-132
ページ数	4
ジャーナル	Journal of Clinical Neuroscience
巻	107
DOI	https://doi.org/10.1016/j.jocn.2022.12.005
出版ステータス	出版済み - 2023/01

ASJC Scopus 主題領域

外科
神経学
臨床神経学
生理学（医学）

文献へのアクセス

10.1016/j.jocn.2022.12.005

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引用スタイル

Yamamoto, M., Okuno, T., Piao, J. L., Shimizu, M., Miyamoto, K., Nukui, T., Kinoshita, M., Koda, T., Dini Haryuni, R., Mochizuki, H., Sugimoto, T., & Nakatsuji, Y. (2023). Identification of double-stranded DNA in the cerebrospinal fluid of patients with acute neuromyelitis optica spectrum disorder. Journal of Clinical Neuroscience, 107, 129-132. https://doi.org/10.1016/j.jocn.2022.12.005

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title = "Identification of double-stranded DNA in the cerebrospinal fluid of patients with acute neuromyelitis optica spectrum disorder",

abstract = "Neuromyelitis optica spectrum disorder (NMOSD) is an inflammatory disease of the central nervous system (CNS) characterized by severe myelitis and optic neuritis. Double-stranded DNA (dsDNA) is involved in the pathogenesis of various autoimmune diseases, such as systemic lupus erythematosus. However, its role in NMOSD remains unclear. In this study, the concentration of dsDNA in the cerebrospinal fluid (CSF) was quantified in 23 patients with NMOSD and 16 patients with other neurological diseases (ONDs). CSF dsDNA levels in patients with NMOSD (median: 0.03 ng/µL) were significantly higher than those in patients with ONDs (median: 0.01 ng/μl). CSF dsDNA levels showed no significant difference before and after treatment. Elevation of CSF dsDNA levels may suggest its essential role in the augmentation of CNS inflammation in patients with NMOSD.",

keywords = "CSF, NMOSD, dsDNA",

author = "Mamoru Yamamoto and Tatsusada Okuno and Piao, {Jin Lan} and Mikito Shimizu and Katsuichi Miyamoto and Takamasa Nukui and Makoto Kinoshita and Toru Koda and {Dini Haryuni}, Ratna and Hideki Mochizuki and Tomoyuki Sugimoto and Yuji Nakatsuji",

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doi = "10.1016/j.jocn.2022.12.005",

language = "英語",

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Yamamoto, M, Okuno, T, Piao, JL, Shimizu, M, Miyamoto, K, Nukui, T, Kinoshita, M, Koda, T, Dini Haryuni, R, Mochizuki, H, Sugimoto, T & Nakatsuji, Y 2023, 'Identification of double-stranded DNA in the cerebrospinal fluid of patients with acute neuromyelitis optica spectrum disorder', Journal of Clinical Neuroscience, vol. 107, pp. 129-132. https://doi.org/10.1016/j.jocn.2022.12.005

TY - JOUR

T1 - Identification of double-stranded DNA in the cerebrospinal fluid of patients with acute neuromyelitis optica spectrum disorder

AU - Yamamoto, Mamoru

AU - Okuno, Tatsusada

AU - Piao, Jin Lan

AU - Shimizu, Mikito

AU - Miyamoto, Katsuichi

AU - Nukui, Takamasa

AU - Kinoshita, Makoto

AU - Koda, Toru

AU - Dini Haryuni, Ratna

AU - Mochizuki, Hideki

AU - Sugimoto, Tomoyuki

AU - Nakatsuji, Yuji

PY - 2023/1

Y1 - 2023/1

N2 - Neuromyelitis optica spectrum disorder (NMOSD) is an inflammatory disease of the central nervous system (CNS) characterized by severe myelitis and optic neuritis. Double-stranded DNA (dsDNA) is involved in the pathogenesis of various autoimmune diseases, such as systemic lupus erythematosus. However, its role in NMOSD remains unclear. In this study, the concentration of dsDNA in the cerebrospinal fluid (CSF) was quantified in 23 patients with NMOSD and 16 patients with other neurological diseases (ONDs). CSF dsDNA levels in patients with NMOSD (median: 0.03 ng/µL) were significantly higher than those in patients with ONDs (median: 0.01 ng/μl). CSF dsDNA levels showed no significant difference before and after treatment. Elevation of CSF dsDNA levels may suggest its essential role in the augmentation of CNS inflammation in patients with NMOSD.

AB - Neuromyelitis optica spectrum disorder (NMOSD) is an inflammatory disease of the central nervous system (CNS) characterized by severe myelitis and optic neuritis. Double-stranded DNA (dsDNA) is involved in the pathogenesis of various autoimmune diseases, such as systemic lupus erythematosus. However, its role in NMOSD remains unclear. In this study, the concentration of dsDNA in the cerebrospinal fluid (CSF) was quantified in 23 patients with NMOSD and 16 patients with other neurological diseases (ONDs). CSF dsDNA levels in patients with NMOSD (median: 0.03 ng/µL) were significantly higher than those in patients with ONDs (median: 0.01 ng/μl). CSF dsDNA levels showed no significant difference before and after treatment. Elevation of CSF dsDNA levels may suggest its essential role in the augmentation of CNS inflammation in patients with NMOSD.

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