抄録
A novel fluorogenic alkyl diazirine photocrosslinker bearing an o-hydroxycinnamate moiety has been developed for identification of the targets of bioactive molecules. The o-hydroxycinnamate moiety can be converted to the corresponding 7-hydroxycoumarin derivative, which should be created on the interacting site within the photocaptured target protein. The label yield and fluorescence intensity have been immensely improved in comparison with our previous aromatic crosslinkers to facilitate target identification in small quantities.
本文言語 | 英語 |
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論文番号 | e202400288 |
ジャーナル | Chemistry - An Asian Journal |
巻 | 19 |
号 | 11 |
DOI | |
出版ステータス | 出版済み - 2024/06/03 |
ASJC Scopus 主題領域
- 生化学
- 化学一般
- 有機化学