Enzymatic synthesis of plant polyketides

Shepo Shi; Hiroyuki Morita; Kiyofumi Wanibuchi; Yuusuke Mizuuchi; Hiroshi Noguchi; Ikuro Abe

doi:10.2174/157017908785133410

Enzymatic synthesis of plant polyketides

Shepo Shi, Hiroyuki Morita, Kiyofumi Wanibuchi, Yuusuke Mizuuchi, Hiroshi Noguchi, Ikuro Abe^*

^*この論文の責任著者

和漢医薬学総合研究所研究開発部門資源開発分野（天然物創薬学領域）

研究成果: ジャーナルへの寄稿 › 総説 › 査読

10 被引用数 (Scopus)

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The functional diversity and catalytic potential of type III polyketide synthases are remarkable. The enzymes catalyze iterative decarboxylative condensations of malonyl unit (Claisen-type C-C bond formation) with a CoA-linked starter molecule to produce structurally diverse, pharmaceutically important secondary metabolites. Recent studies have revealed intimate structural details of the enzyme reactions, which enabled the precursor-directed and structure-based engineered biosynthesis of unnatural polyketides.

本文言語	英語
ページ（範囲）	250-266
ページ数	17
ジャーナル	Current Organic Synthesis
巻	5
号	3
DOI	https://doi.org/10.2174/157017908785133410
出版ステータス	出版済み - 2008/08

ASJC Scopus 主題領域

生化学
有機化学

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10.2174/157017908785133410

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title = "Enzymatic synthesis of plant polyketides",

abstract = "The functional diversity and catalytic potential of type III polyketide synthases are remarkable. The enzymes catalyze iterative decarboxylative condensations of malonyl unit (Claisen-type C-C bond formation) with a CoA-linked starter molecule to produce structurally diverse, pharmaceutically important secondary metabolites. Recent studies have revealed intimate structural details of the enzyme reactions, which enabled the precursor-directed and structure-based engineered biosynthesis of unnatural polyketides.",

keywords = "Combinatorial biosynthesis, Enzymatic synthesis, Precursor-directed biosynthesis, Structure-based engineered biosynthesis, Type III polyketide synthase",

author = "Shepo Shi and Hiroyuki Morita and Kiyofumi Wanibuchi and Yuusuke Mizuuchi and Hiroshi Noguchi and Ikuro Abe",

year = "2008",

month = aug,

doi = "10.2174/157017908785133410",

language = "英語",

volume = "5",

pages = "250--266",

journal = "Current Organic Synthesis",

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TY - JOUR

T1 - Enzymatic synthesis of plant polyketides

AU - Shi, Shepo

AU - Morita, Hiroyuki

AU - Wanibuchi, Kiyofumi

AU - Mizuuchi, Yuusuke

AU - Noguchi, Hiroshi

AU - Abe, Ikuro

PY - 2008/8

Y1 - 2008/8

N2 - The functional diversity and catalytic potential of type III polyketide synthases are remarkable. The enzymes catalyze iterative decarboxylative condensations of malonyl unit (Claisen-type C-C bond formation) with a CoA-linked starter molecule to produce structurally diverse, pharmaceutically important secondary metabolites. Recent studies have revealed intimate structural details of the enzyme reactions, which enabled the precursor-directed and structure-based engineered biosynthesis of unnatural polyketides.

AB - The functional diversity and catalytic potential of type III polyketide synthases are remarkable. The enzymes catalyze iterative decarboxylative condensations of malonyl unit (Claisen-type C-C bond formation) with a CoA-linked starter molecule to produce structurally diverse, pharmaceutically important secondary metabolites. Recent studies have revealed intimate structural details of the enzyme reactions, which enabled the precursor-directed and structure-based engineered biosynthesis of unnatural polyketides.

KW - Combinatorial biosynthesis

KW - Enzymatic synthesis

KW - Precursor-directed biosynthesis

KW - Structure-based engineered biosynthesis

KW - Type III polyketide synthase

UR - http://www.scopus.com/inward/record.url?scp=54149105557&partnerID=8YFLogxK

U2 - 10.2174/157017908785133410

DO - 10.2174/157017908785133410

M3 - 総説

AN - SCOPUS:54149105557

SN - 1570-1794

VL - 5

SP - 250

EP - 266

JO - Current Organic Synthesis

JF - Current Organic Synthesis

IS - 3

ER -

Enzymatic synthesis of plant polyketides

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