Efficacy and safety of pramipexole extended-release in clinical practice for Parkinson's disease

Yoshiharu Taguchi, Shutaro Takashima, Nobuhiro Dougu, Takamasa Nukui, Hirofumi Konishi, Koji Yoshida, Tomohiro Hayashi, Mamoru Yamamoto, Kortaro Tanaka

研究成果: ジャーナルへの寄稿学術論文査読

抄録

Objectives : To elucidate the efficacy of pramipexole extended-release (PPX-ER) formulation for the treatment of Parkinson's disease (PD) in clinical practice, we investigated PD patients who received regular outpatient treatment with PPX-ER at our department. Methods : Fifty-five patients in whom pramipexole immediate-release (PPX-IR) had been switched to PPX-ER (switch patients) and 37 patients who had been newly administered PPX-ER (newly-administered patients) at our department between July 2011 and May 2013 were included in the study. We retrospectively investigated the clinical characteristics and the efficacy and safety of treatment with PPX-ER based on patients' medical records. Results : Baseline characteristics of switch patients were as follows: age, 68.7 ± 8.3 years; female, 60.0%; duration of PD, 10.4 ± 5.8 years; Hoehn & Yahr stage, 3.0 ± 0.7; and the presence of wearing-off phenomenon, 58.2%. Improvement was observed in 21 out of 53 patients who were evaluated efficacy (39.6%). Side effects occurred in 20.0% of patients (11/55 patients), and 90.9% of patients (50/55 patients) continued PPX-ER throughout the study. In the newly-administered patients, baseline characteristics were as follows: age, 67.7 ± 8.9 years; female, 56.8%, duration of PD, 6.6 ± 5.4 years, Hoehn & Yahr stage, 2.4 ± 0.8; and the presence of wearing-off phenomenon, 32.4%. Sixteen out of 31 patients who were evaluated efficacy showed an improvement (51.6%). 10.8% of patients (4/37 patients) reported side effects, and 94.6% of patients (35/37 patients) continued PPX-ER Conclusions : Switching from PPX-IR to PPX-ER and newly administration of PPX-ER in PD patients are effective and well tolerated in clinical practice.

本文言語英語
ページ(範囲)449-454
ページ数6
ジャーナルTherapeutic Research
35
4
出版ステータス出版済み - 2014

ASJC Scopus 主題領域

  • 医学一般

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