Dual Engineering of Olivetolic Acid Cyclase and Tetraketide Synthase to Generate Longer Alkyl-Chain Olivetolic Acid Analogs

Yuan E. Lee, Yu Nakashima, Takeshi Kodama, Xinrui Chen, Hiroyuki Morita

研究成果: ジャーナルへの寄稿学術論文査読

抄録

The therapeutic effects of Δ9-tetrahydrocannabinol (Δ9-THC) can be enhanced by modifications of the pentyl moiety at C-3. The engineering of Cannabis sativa olivetolic acid cyclase and tetraketide synthase with F24I and L190G substitutions, respectively, in the biosynthesis of Δ9-THC serves as a platform for the generation of resorcylic acids up to 6-undecylresorcylic acid. These results provide insights into the development of THC analogs with chemically distinct acyl moieties at C-3.
本文言語日本
ページ(範囲)410-414
ページ数5
ジャーナルOrganic Letters
24
1
DOI
出版ステータス出版済み - 2022/01/14

引用スタイル