Cytotoxic potential of dihydrochalcones from Eriosema glomeratum and their semi-synthetic derivatives

Gaétan Tchangou Tabakam, Takeshi Kodama, Marthe Aimée Tchuente Tchuenmogne, Nhat Nam Hoang, Battsengel Nomin-Erdene, Silvère Augustin Ngouela, Mathieu Tene, Hiroyuki Morita, Maurice Ducret Awouafack*

*この論文の責任著者

研究成果: ジャーナルへの寄稿学術論文査読

1 被引用数 (Scopus)

抄録

In the search of cytotoxic dihydrochalcones, this investigation led to the isolation of seven compounds (1-7) from Eriosema glomeratum and the preparation of eight derivatives (8-15). The cytotoxicity of samples was evaluated against lung (A549), breast (MCF-7), and cervical (HeLa) human cancer cells. The CH2Cl2/MeOH extract of the aerial part had strong cytotoxicity against all cells [IC50 11.2 (MCF-7), 8.4 (HeLa) and 13.1 (A549) μg/mL]. A strong activity was also displayed by the n-hexane fraction on MCF-7 (IC50 11.2 μg/mL). The precursor 3 and the derivative 8 were specifically found as strong cytotoxic agents toward MCF-7 (7.6 μM) and HeLa (3.1 μM), respectively and were more effective than the positive control. Derivatives 8 (3.1 μM) and 9 (21.3 μM) against HeLa were most potent than their precursor 3 (23.7 μM). This is the first preparation of 8-14 as well as the cytotoxicity of 3, 4, 8-15, fractions, and extract.

本文言語英語
ページ(範囲)186-197
ページ数12
ジャーナルNatural Product Research
38
2
DOI
出版ステータス出版済み - 2024

ASJC Scopus 主題領域

  • 分析化学
  • 生化学
  • 植物科学
  • 有機化学

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