Behçet's disease with severe autonomic disorders developing after herpes zoster

Serina Koto; Masataka Umeda; Hiroaki Kawano; Yushiro Endo; Toshimasa Shimizu; Tomohiro Koga; Kunihiro Ichinose; Hideki Nakamura; Akihiro Mukaino; Osamu Higuchi; Shunya Nakane; Atsushi Kawakami

doi:10.2169/internalmedicine.3954-19

Behçet's disease with severe autonomic disorders developing after herpes zoster

Serina Koto, Masataka Umeda^*, Hiroaki Kawano, Yushiro Endo, Toshimasa Shimizu, Tomohiro Koga, Kunihiro Ichinose, Hideki Nakamura, Akihiro Mukaino, Osamu Higuchi, Shunya Nakane, Atsushi Kawakami

^*この論文の責任著者

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

3 被引用数 (Scopus)

抄録

A 58-year-old Japanese woman with herpes zoster developed Behçet's disease (BD) with symptoms including orthostatic intolerance as an autonomic disorder. Multiple immune-suppressive therapies and a β-blocker successfully controlled both the disease activity of BD and the autonomic disorders. A cytokine multiplex analysis of her serum revealed the elevation of proinflammatory cytokines [interleukin (IL)-1, IL-6, IL-12, tumor necrosis factor alfa (TNFα), and interferon gamma (IFN-γ)] and a low IL-10 concentration. IL-10 production is reported to be important for defense against herpes zoster virus (VZV). Insufficient IL-10 production is reported in BD. The reactivation of VZV with this cytokine profile suggests that BD will develop with various symptoms, including severe autonomic disorders.

本文言語	英語
ページ（範囲）	1099-1104
ページ数	6
ジャーナル	Internal Medicine
巻	59
号	8
DOI	https://doi.org/10.2169/internalmedicine.3954-19
出版ステータス	出版済み - 2020

ASJC Scopus 主題領域

内科学

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10.2169/internalmedicine.3954-19

引用スタイル

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title = "Beh{\c c}et's disease with severe autonomic disorders developing after herpes zoster",

abstract = "A 58-year-old Japanese woman with herpes zoster developed Beh{\c c}et's disease (BD) with symptoms including orthostatic intolerance as an autonomic disorder. Multiple immune-suppressive therapies and a β-blocker successfully controlled both the disease activity of BD and the autonomic disorders. A cytokine multiplex analysis of her serum revealed the elevation of proinflammatory cytokines [interleukin (IL)-1, IL-6, IL-12, tumor necrosis factor alfa (TNFα), and interferon gamma (IFN-γ)] and a low IL-10 concentration. IL-10 production is reported to be important for defense against herpes zoster virus (VZV). Insufficient IL-10 production is reported in BD. The reactivation of VZV with this cytokine profile suggests that BD will develop with various symptoms, including severe autonomic disorders.",

keywords = "Autonomic disorder, Beh{\c c}et's disease, Herpes zoster, IL-10",

author = "Serina Koto and Masataka Umeda and Hiroaki Kawano and Yushiro Endo and Toshimasa Shimizu and Tomohiro Koga and Kunihiro Ichinose and Hideki Nakamura and Akihiro Mukaino and Osamu Higuchi and Shunya Nakane and Atsushi Kawakami",

year = "2020",

doi = "10.2169/internalmedicine.3954-19",

language = "英語",

volume = "59",

pages = "1099--1104",

journal = "Internal Medicine",

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T1 - Behçet's disease with severe autonomic disorders developing after herpes zoster

AU - Koto, Serina

AU - Umeda, Masataka

AU - Kawano, Hiroaki

AU - Endo, Yushiro

AU - Shimizu, Toshimasa

AU - Koga, Tomohiro

AU - Ichinose, Kunihiro

AU - Nakamura, Hideki

AU - Mukaino, Akihiro

AU - Higuchi, Osamu

AU - Nakane, Shunya

AU - Kawakami, Atsushi

PY - 2020

Y1 - 2020

N2 - A 58-year-old Japanese woman with herpes zoster developed Behçet's disease (BD) with symptoms including orthostatic intolerance as an autonomic disorder. Multiple immune-suppressive therapies and a β-blocker successfully controlled both the disease activity of BD and the autonomic disorders. A cytokine multiplex analysis of her serum revealed the elevation of proinflammatory cytokines [interleukin (IL)-1, IL-6, IL-12, tumor necrosis factor alfa (TNFα), and interferon gamma (IFN-γ)] and a low IL-10 concentration. IL-10 production is reported to be important for defense against herpes zoster virus (VZV). Insufficient IL-10 production is reported in BD. The reactivation of VZV with this cytokine profile suggests that BD will develop with various symptoms, including severe autonomic disorders.

AB - A 58-year-old Japanese woman with herpes zoster developed Behçet's disease (BD) with symptoms including orthostatic intolerance as an autonomic disorder. Multiple immune-suppressive therapies and a β-blocker successfully controlled both the disease activity of BD and the autonomic disorders. A cytokine multiplex analysis of her serum revealed the elevation of proinflammatory cytokines [interleukin (IL)-1, IL-6, IL-12, tumor necrosis factor alfa (TNFα), and interferon gamma (IFN-γ)] and a low IL-10 concentration. IL-10 production is reported to be important for defense against herpes zoster virus (VZV). Insufficient IL-10 production is reported in BD. The reactivation of VZV with this cytokine profile suggests that BD will develop with various symptoms, including severe autonomic disorders.

KW - Autonomic disorder

KW - Behçet's disease

KW - Herpes zoster

KW - IL-10

UR - http://www.scopus.com/inward/record.url?scp=85083544211&partnerID=8YFLogxK

U2 - 10.2169/internalmedicine.3954-19

DO - 10.2169/internalmedicine.3954-19

M3 - 学術論文

C2 - 32009095

AN - SCOPUS:85083544211

SN - 0918-2918

VL - 59

SP - 1099

EP - 1104

JO - Internal Medicine

JF - Internal Medicine

IS - 8

ER -

Behçet's disease with severe autonomic disorders developing after herpes zoster

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