@article{bb9a9548351941ea9adebcc389467a06,
title = "Artificial association of pre-stored information to generate a qualitatively new memory",
abstract = "Memory is thought to be stored in the brain as an ensemble of cells activated during learning. Although optical stimulation of a cell ensemble triggers the retrieval of the corresponding memory, it is unclear how the association of information occurs at the cell ensemble level. Using optogenetic stimulation without any sensory input in mice, we found that an artificial association between stored, nonrelated contextual, and fear information was generated through the synchronous activation of distinct cell ensembles corresponding to the stored information. This artificial association shared characteristics with physiologically associated memories, such as N-methyl-D-aspartate receptor activity and protein synthesis dependence. These findings suggest that the association of information is achieved through the synchronous activity of distinct cell ensembles. This mechanism may underlie memory updating by incorporating novel information into pre-existing networks to form qualitatively new memories.",
author = "Noriaki Ohkawa and Yoshito Saitoh and Akinobu Suzuki and Shuhei Tsujimura and Emi Murayama and Sakurako Kosugi and Hirofumi Nishizono and Mina Matsuo and Yukari Takahashi and Masashi Nagase and Sugimura, {Yae K.} and Watabe, {Ayako M.} and Fusao Kato and Kaoru Inokuchi",
note = "Funding Information: We thank K. Deisseroth (Stanford University) for the hChR2 (T159C) cDNA, H. Hioki and T. Kaneko (Kyoto University) for the TRE-EGFP LV vector, H. Nomura (University of Tokyo) for the catFISH method, I. Takasaki and Y. Tabuchi (University of Toyama) for setting up the lentiviral experiments, N. Matsuo (Kyoto University) for information about the c-fos::tTA mouse, A. Yamanaka (Nagoya University) for technical advice regarding optogenetics, and T. Kitamura (Massachusetts Institute of Technology) for help setting up and for valuable discussion about behavioral analysis. This work was supported by the Core Research for Evolutional Science and Technology (CREST) program of the Japan Science and Technology Agency (JST), JSPS KAKENHI grant number 23220009, a Grant-in-Aid for Scientific Research on Innovative Areas “Memory dynamism” (25115002) from the MEXT, the Mitsubishi Foundation, the Uehara Memorial Foundation, and the Takeda Science Foundation support to K.I., and JSPS KAKENHI grant number 24650164 and a Hokugin Research Grant to N.O. ",
year = "2015",
doi = "10.1016/j.celrep.2015.03.017",
language = "英語",
volume = "11",
pages = "261--269",
journal = "Cell Reports",
issn = "2211-1247",
publisher = "Cell Press",
number = "2",
}