A New Sterol From the Polypore Fungus Ganoderma luteomarginatum and Its Cytotoxic Activities

Zin Paing Htoo; Takeshi Kodama; Nwet Nwet Win; Naotaka Ikumi; Ken Ichi Shiokawa; Hiroyuki Morita

doi:10.1177/1934578X221098852

A New Sterol From the Polypore Fungus Ganoderma luteomarginatum and Its Cytotoxic Activities

Zin Paing Htoo, Takeshi Kodama, Nwet Nwet Win, Naotaka Ikumi, Ken Ichi Shiokawa, Hiroyuki Morita^*

^*この論文の責任著者

和漢医薬学総合研究所研究開発部門資源開発分野（天然物創薬学領域）

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

抄録

A new sterol, ganolutol A (1), together with 4 known compounds 2 to 5, were isolated from the polypore fungus Ganoderma luteomarginatum collected in Myanmar. The chemical structures of the isolated compounds were determined based on extensive spectroscopic analyses in conjunction with comparisons with published data. Compounds 1 to 4 exhibited moderate cytotoxic activities against A549 (lung), MCF-7 (breast), and HeLa (cervical) human cancer cell lines, with IC₅₀ values ranging from 10.1 to 86.6 μM.

本文言語	英語
ジャーナル	Natural Product Communications
巻	17
号	5
DOI	https://doi.org/10.1177/1934578X221098852
出版ステータス	出版済み - 2022/05

ASJC Scopus 主題領域

創薬
補完代替医療
植物科学
薬理学

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10.1177/1934578X221098852

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title = "A New Sterol From the Polypore Fungus Ganoderma luteomarginatum and Its Cytotoxic Activities",

abstract = "A new sterol, ganolutol A (1), together with 4 known compounds 2 to 5, were isolated from the polypore fungus Ganoderma luteomarginatum collected in Myanmar. The chemical structures of the isolated compounds were determined based on extensive spectroscopic analyses in conjunction with comparisons with published data. Compounds 1 to 4 exhibited moderate cytotoxic activities against A549 (lung), MCF-7 (breast), and HeLa (cervical) human cancer cell lines, with IC50 values ranging from 10.1 to 86.6 μM.",

keywords = "Ganoderma luteomarginatum, Ganodermataceae, cytotoxicity, ergostane, polypore fungus",

author = "Htoo, {Zin Paing} and Takeshi Kodama and Win, {Nwet Nwet} and Naotaka Ikumi and Shiokawa, {Ken Ichi} and Hiroyuki Morita",

note = "Publisher Copyright: {\textcopyright} The Author(s) 2022.",

year = "2022",

month = may,

doi = "10.1177/1934578X221098852",

language = "英語",

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AU - Htoo, Zin Paing

AU - Kodama, Takeshi

AU - Win, Nwet Nwet

AU - Ikumi, Naotaka

AU - Shiokawa, Ken Ichi

AU - Morita, Hiroyuki

N1 - Publisher Copyright: © The Author(s) 2022.

PY - 2022/5

Y1 - 2022/5

N2 - A new sterol, ganolutol A (1), together with 4 known compounds 2 to 5, were isolated from the polypore fungus Ganoderma luteomarginatum collected in Myanmar. The chemical structures of the isolated compounds were determined based on extensive spectroscopic analyses in conjunction with comparisons with published data. Compounds 1 to 4 exhibited moderate cytotoxic activities against A549 (lung), MCF-7 (breast), and HeLa (cervical) human cancer cell lines, with IC50 values ranging from 10.1 to 86.6 μM.

AB - A new sterol, ganolutol A (1), together with 4 known compounds 2 to 5, were isolated from the polypore fungus Ganoderma luteomarginatum collected in Myanmar. The chemical structures of the isolated compounds were determined based on extensive spectroscopic analyses in conjunction with comparisons with published data. Compounds 1 to 4 exhibited moderate cytotoxic activities against A549 (lung), MCF-7 (breast), and HeLa (cervical) human cancer cell lines, with IC50 values ranging from 10.1 to 86.6 μM.

KW - Ganoderma luteomarginatum

KW - Ganodermataceae

KW - cytotoxicity

KW - ergostane

KW - polypore fungus

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SN - 1934-578X

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JO - Natural Product Communications

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A New Sterol From the Polypore Fungus Ganoderma luteomarginatum and Its Cytotoxic Activities

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