TY - JOUR
T1 - A New Monoterpenoid Glucoindole Alkaloid From Dipsacus asper
AU - Li, Feng
AU - Nishidono, Yuto
AU - Tanaka, Ken
AU - Watanabe, Shiro
AU - Tezuka, Yasuhiro
N1 - Publisher Copyright:
© The Author(s) 2020.
PY - 2020
Y1 - 2020
N2 - The monoterpenoid glucoindole alkaloids comprise a large class of structurally complex natural products that have attracted widespread attention owing to their biological activities and structural diversity. In the present study, we investigated the constituents of a methanol extract of Dipsacus asper roots and obtained a new monoterpenoid glucoindole alkaloid, (3R,5S)-5-carboxyvincosidic acid 22-loganin ester (1), together with the known alkaloid (3S,5S)-5-carboxystrictosidic acid 22-loganin ester (dipsaperine) (2). We herein report our structural elucidation of 1 by spectroscopic analysis and its anti-inflammatory activity as revealed by its inhibition of nitric oxide production in lipopolysaccharide-activated RAW264.7 cells.
AB - The monoterpenoid glucoindole alkaloids comprise a large class of structurally complex natural products that have attracted widespread attention owing to their biological activities and structural diversity. In the present study, we investigated the constituents of a methanol extract of Dipsacus asper roots and obtained a new monoterpenoid glucoindole alkaloid, (3R,5S)-5-carboxyvincosidic acid 22-loganin ester (1), together with the known alkaloid (3S,5S)-5-carboxystrictosidic acid 22-loganin ester (dipsaperine) (2). We herein report our structural elucidation of 1 by spectroscopic analysis and its anti-inflammatory activity as revealed by its inhibition of nitric oxide production in lipopolysaccharide-activated RAW264.7 cells.
KW - Dipsacus asper
KW - NO production inhibitory activity
KW - monoterpenoid glucoindole alkaloid
UR - http://www.scopus.com/inward/record.url?scp=85087931063&partnerID=8YFLogxK
U2 - 10.1177/1934578X20917292
DO - 10.1177/1934578X20917292
M3 - 学術論文
AN - SCOPUS:85087931063
SN - 1934-578X
VL - 15
JO - Natural Product Communications
JF - Natural Product Communications
IS - 4
ER -