A New Monoterpene from the Rhizomes of Alpinia galanga and Its Anti-Vpr Activity

Nhat Nam Hoang; Takeshi Kodama; Nwet Nwet Win; Prema; Kiep Minh Do; Ikuro Abe; Hiroyuki Morita

doi:10.1002/cbdv.202100401

A New Monoterpene from the Rhizomes of Alpinia galanga and Its Anti-Vpr Activity

Nhat Nam Hoang, Takeshi Kodama, Nwet Nwet Win, Prema, Kiep Minh Do, Ikuro Abe, Hiroyuki Morita^*

^*この論文の責任著者

和漢医薬学総合研究所研究開発部門資源開発分野（天然物創薬学領域）

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

9 被引用数 (Scopus)

抄録

A new menthane-type monoterpene, alpigalanol (1), together with four known terpenes (2–5) were isolated from the ethyl acetate soluble fraction of the 70 % ethanol extract of the Alpinia galanga rhizomes. The structure of 1 was determined by spectroscopic analyses, including 1D- and 2D-NMR. The extract of the A. galanga rhizomes and all isolated compounds (1–5) possessed Vpr inhibitory activities against the TREx-HeLa-Vpr cells at a concentration of 1.25 μM without showing any cytotoxicity.

本文言語	英語
論文番号	e2100401
ジャーナル	Chemistry and Biodiversity
巻	18
号	10
DOI	https://doi.org/10.1002/cbdv.202100401
出版ステータス	出版済み - 2021/10

ASJC Scopus 主題領域

バイオエンジニアリング
生化学
化学一般
分子医療
分子生物学

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10.1002/cbdv.202100401

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title = "A New Monoterpene from the Rhizomes of Alpinia galanga and Its Anti-Vpr Activity",

abstract = "A new menthane-type monoterpene, alpigalanol (1), together with four known terpenes (2–5) were isolated from the ethyl acetate soluble fraction of the 70 % ethanol extract of the Alpinia galanga rhizomes. The structure of 1 was determined by spectroscopic analyses, including 1D- and 2D-NMR. The extract of the A. galanga rhizomes and all isolated compounds (1–5) possessed Vpr inhibitory activities against the TREx-HeLa-Vpr cells at a concentration of 1.25 μM without showing any cytotoxicity.",

keywords = "Alpinia galanga, Viral protein R, monoterpene, sesquiterpene",

author = "{Nam Hoang}, Nhat and Takeshi Kodama and {Nwet Win}, Nwet and Prema and {Minh Do}, Kiep and Ikuro Abe and Hiroyuki Morita",

note = "Publisher Copyright: {\textcopyright} 2021 Wiley-VHCA AG, Zurich, Switzerland.",

year = "2021",

month = oct,

doi = "10.1002/cbdv.202100401",

language = "英語",

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journal = "Chemistry and Biodiversity",

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T1 - A New Monoterpene from the Rhizomes of Alpinia galanga and Its Anti-Vpr Activity

AU - Nam Hoang, Nhat

AU - Kodama, Takeshi

AU - Nwet Win, Nwet

AU - Prema,

AU - Minh Do, Kiep

AU - Abe, Ikuro

AU - Morita, Hiroyuki

PY - 2021/10

Y1 - 2021/10

N2 - A new menthane-type monoterpene, alpigalanol (1), together with four known terpenes (2–5) were isolated from the ethyl acetate soluble fraction of the 70 % ethanol extract of the Alpinia galanga rhizomes. The structure of 1 was determined by spectroscopic analyses, including 1D- and 2D-NMR. The extract of the A. galanga rhizomes and all isolated compounds (1–5) possessed Vpr inhibitory activities against the TREx-HeLa-Vpr cells at a concentration of 1.25 μM without showing any cytotoxicity.

AB - A new menthane-type monoterpene, alpigalanol (1), together with four known terpenes (2–5) were isolated from the ethyl acetate soluble fraction of the 70 % ethanol extract of the Alpinia galanga rhizomes. The structure of 1 was determined by spectroscopic analyses, including 1D- and 2D-NMR. The extract of the A. galanga rhizomes and all isolated compounds (1–5) possessed Vpr inhibitory activities against the TREx-HeLa-Vpr cells at a concentration of 1.25 μM without showing any cytotoxicity.

KW - Alpinia galanga

KW - Viral protein R

KW - monoterpene

KW - sesquiterpene

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DO - 10.1002/cbdv.202100401

M3 - 学術論文

C2 - 34415099

AN - SCOPUS:85115278061

SN - 1612-1872

VL - 18

JO - Chemistry and Biodiversity

JF - Chemistry and Biodiversity

IS - 10

M1 - e2100401

ER -

A New Monoterpene from the Rhizomes of Alpinia galanga and Its Anti-Vpr Activity

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