TY - JOUR
T1 - A new 3,4-seco-isopimarane and three new isopimarane diterpenoids from Kaempferia champasakensis collected from Vietnam and their cytotoxic activities
AU - Do, Kiep Minh
AU - Hoshino, Shotaro
AU - Kodama, Takeshi
AU - Nguyen, Hien Minh
AU - Van Le, Son
AU - Ikumi, Naotaka
AU - Onaka, Hiroyasu
AU - Morita, Hiroyuki
N1 - Publisher Copyright:
© The Author(s) under exclusive licence to The Japanese Society of Pharmacognosy 2024.
PY - 2024
Y1 - 2024
N2 - A phytochemical investigation of Kaempferia champasakensis rhizomes led to the isolation of a new 3,4-seco-isopimarane diterpene, kaempferiol A (1), and three new isopimarane diterpenes, kaempferiols B–D (2–4), together with six known isopimarane diterpenes (5–10). The structures of 1–4 were elucidated by extensive spectroscopic analyses, including HR-ESI–MS, UV, IR, and 1D and 2D NMR. The absolute configurations of 1, 3, and 4 were determined by ECD calculations, while that of 2 was established using the modified Mosher method. All isolated compounds were tested for cytotoxicity against three human cancer cell lines, lung cancer (A549), cervical cancer (HeLa), and breast cancer (MCF-7). Among them, 6 and 7 showed moderate cytotoxic activities against the three tested cell lines, with IC50 values ranging from 38.04 to 27.77 μM, respectively. Graphical abstract: (Figure presented.)
AB - A phytochemical investigation of Kaempferia champasakensis rhizomes led to the isolation of a new 3,4-seco-isopimarane diterpene, kaempferiol A (1), and three new isopimarane diterpenes, kaempferiols B–D (2–4), together with six known isopimarane diterpenes (5–10). The structures of 1–4 were elucidated by extensive spectroscopic analyses, including HR-ESI–MS, UV, IR, and 1D and 2D NMR. The absolute configurations of 1, 3, and 4 were determined by ECD calculations, while that of 2 was established using the modified Mosher method. All isolated compounds were tested for cytotoxicity against three human cancer cell lines, lung cancer (A549), cervical cancer (HeLa), and breast cancer (MCF-7). Among them, 6 and 7 showed moderate cytotoxic activities against the three tested cell lines, with IC50 values ranging from 38.04 to 27.77 μM, respectively. Graphical abstract: (Figure presented.)
KW - 3,4-seco-isopimarane diterpenoid
KW - Cytotoxicity
KW - Isopimarane
KW - Kaempferia champasakensis
KW - Kaempferiols A–D
UR - http://www.scopus.com/inward/record.url?scp=85188354672&partnerID=8YFLogxK
U2 - 10.1007/s11418-024-01789-z
DO - 10.1007/s11418-024-01789-z
M3 - 学術論文
C2 - 38517624
AN - SCOPUS:85188354672
SN - 1340-3443
JO - Natural Medicines
JF - Natural Medicines
ER -