TY - JOUR
T1 - A case of IL-6 producing malignant mesothelioma of abdomen with thrombocytosis
AU - Fukuyama, Tomoki
AU - Kawahara, Hiromu
AU - Yamada, Masayoshi
AU - Hayashi, Nobuhiko
AU - Yano, Hirokazu
AU - Fukura, Masayuki
AU - Ozaki, Kazuaki
AU - Tsuchishima, Mutsumi
AU - Takase, Shujiro
AU - Arisawa, Tomiyasu
AU - Omote, Kazuhiko
AU - Nojima, Takayuki
PY - 2009
Y1 - 2009
N2 - A 77-year-old man was admitted to our hospital with abdominal pain and ascites. He had an occupational history of working with asbestos. Abdominal CT showed multiple nodular lesions with enhancement by contrast medium in the cavity. Platelet counts, CRP and serum IL-6 level were increased. Biopsied materials obtained by laparoscopy showed oval cells with rich cytoplasm growing in an epithelial pattern. To clarify the characteristics of the cells, immunohistochemistry was performed. Calretinin and CK5/6 were positive, and CEA, S-100 protein, c-kit and CD34 were negative, result in confirmation of a diagnosis of malignant mesothelioma. Because IL-6, IL-6 receptor and VEGF were expressed markedly, the patient received chemotherapy for IL-6 suppression. During the treatment, thrombocytosis imploved satisfactorily.
AB - A 77-year-old man was admitted to our hospital with abdominal pain and ascites. He had an occupational history of working with asbestos. Abdominal CT showed multiple nodular lesions with enhancement by contrast medium in the cavity. Platelet counts, CRP and serum IL-6 level were increased. Biopsied materials obtained by laparoscopy showed oval cells with rich cytoplasm growing in an epithelial pattern. To clarify the characteristics of the cells, immunohistochemistry was performed. Calretinin and CK5/6 were positive, and CEA, S-100 protein, c-kit and CD34 were negative, result in confirmation of a diagnosis of malignant mesothelioma. Because IL-6, IL-6 receptor and VEGF were expressed markedly, the patient received chemotherapy for IL-6 suppression. During the treatment, thrombocytosis imploved satisfactorily.
UR - http://www.scopus.com/inward/record.url?scp=71949100325&partnerID=8YFLogxK
M3 - 学術論文
C2 - 19346724
AN - SCOPUS:71949100325
SN - 0446-6586
VL - 106
SP - 546
EP - 553
JO - Journal of Japanese Society of Gastroenterology
JF - Journal of Japanese Society of Gastroenterology
IS - 4
ER -