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糖尿病とうつ病の嗅覚/オレキシン系のレジリエンス促進による連動的治療法の開発
Sasaoka, Toshiyasu
(研究代表者)
Tsuneki, Hiroshi
(研究分担者)
Wada, Tsutomu
(研究分担者)
病態制御薬理学研究室
臨床薬品作用学研究室
概要
フィンガープリント
研究成果
(11)
フィンガープリント
このプロジェクトで扱った研究トピックを検索します。これらのラベルは、プロジェクトの研究費/助成金に基づいて生成されます。これらがまとまってユニークなフィンガープリントを構成します。
並べ替え順
重み付け
アルファベット順
Keyphrases
Recognition Memory
100%
Lemborexant
100%
Growth Factor Signaling
100%
Platelet-derived Growth factor-BB (PDGF-BB)
100%
Pericytes
100%
C-peptide
100%
Brain-derived Neurotrophic Factor
100%
Hypothalamic Obesity
100%
Neurotrophic Factor Expression
100%
Hypothalamic Inflammation
100%
Diabetic Mice
100%
Cell Memory
100%
C-terminal Peptide
100%
Glucose Tolerance
100%
Human Brain
71%
Brain Pericytes
71%
KO Mice
57%
Secretome
57%
Db Mouse
44%
Platelet-derived Growth Factor Receptor (PDGFR)
42%
Lipopolysaccharide
42%
Obesity
42%
High-fat Diet
39%
Type 2 Diabetic
33%
C(X)
28%
Conditioned Medium
28%
Receptor Knockout
28%
Energy Metabolism
28%
Oncogene
28%
Bone Marrow-derived Macrophages
28%
Knock-in Mouse Model
28%
Hypothalamus
28%
Glucose Metabolism
22%
REM Sleep
22%
Rapid Eye Movement Sleep
22%
MRNA Expression
21%
C57BL
18%
Growth Factors
14%
Activation-regulated Chemokine
14%
Mitogen-activated Protein Kinase
14%
Thymus
14%
Chemokine Receptor
14%
Pathophysiology
14%
Energy Consumption
14%
Flox
14%
Blood-brain Barrier
14%
Growth Factor Receptor Signaling
14%
Inflammatory Chemokines
14%
Signal Transduction
14%
Costimulation
14%
Microglial Cells
14%
Cyclic Adenosine Monophosphate (cAMP)
14%
Glycolysis
14%
CXCL1
14%
Western Blotting
14%
Chemokine Ligand 5
14%
Chronic Inflammation
14%
Seahorse XFe24
14%
Intracellular Metabolism
14%
Calcium-dependent Protein Kinase
14%
CXCL5
14%
Tamoxifen Inducible
14%
Chemokines
14%
Chemokine (C-C motif) Ligand 2 (CCL2)
14%
Proopiomelanocortin Neurons
14%
Macrophage Polarization
14%
Neutrophil-activating Protein
14%
Cytokine Array
14%
Receptor Antagonist
14%
Inflammatory Phenotype
14%
Body Weight Gain
14%
Microglia
14%
Metabolic Phenotype
14%
Neuron-specific
14%
Acute Inflammation
14%
Inflammatory Gene Expression
14%
Monocyte Chemoattractant protein-1 (MCP-1)
14%
MRNA Level
14%
Orexin
14%
Y-maze
11%
Sleep Disruption
11%
Wake Episodes
11%
Diabetes Distress
11%
Physical Activity
11%
Sleep Disorders
11%
Dark Phase
11%
Type 2 Diabetes Mellitus (T2DM)
11%
Diabetic
11%
Behavioral Abnormalities
11%
Obesity Risk
11%
Glucose Intolerance
11%
Orexin Receptors
11%
Non-diabetic
11%
Light Phase
11%
Insomnia
11%
Wakefulness
11%
Locomotor Activity
11%
Forced Swim Test
11%
Elevated Plus Maze
11%
Glucose-stimulated Insulin Secretion
11%
Single Administration
11%
High K+
7%
Phosgene
7%
Gene Expression
7%
Glutamate
7%
Protein Kinase
7%
Neuronal Cell Death
7%
Cell Viability
7%
Mammalian Species
7%
Forskolin
7%
Protective Effect
7%
3D Structure
7%
Cerebral Cortex
7%
Induced Neuronal Cells
7%
N-terminus
7%
Amino Acids
7%
Conserved Function
7%
Functional Substances
7%
Intracerebroventricular Injection
7%
Functional Peptides
7%
Memory Behavior
7%
Novel Object Recognition Memory
7%
H-89
7%
Phosphodiesterase Inhibitors
7%
Rolipram
7%
Mammalian Brain
7%
Hippocampus
7%
Protein Post-translational Modification
7%
Precursor Protein
7%
Orexin Neuron
7%
C-Fos
7%
Neuroscience
Chemokine
100%
C-Terminus
100%
Lipopolysaccharide
100%
Lemborexant
100%
Recognition Memory
100%
Macrophage
100%
C Peptide
100%
Platelet Derived Growth Factor BB
100%
Platelet-Derived Growth Factor Receptor
100%
Brain-Derived Neurotrophic Factor
100%
Neurotrophic Factor Expression
100%
Platelet-Derived Growth Factor
100%
Energy Metabolism
66%
Hypothalamus
66%
Metabolic Pathway
55%
Messenger RNA
54%
Gene Expression
40%
C-Fos
40%
Monocyte Chemotactic Protein 1
33%
Western Blotting
33%
Mitogen-Activated Protein Kinase
33%
Calcium Calmodulin Dependent Protein Kinase
33%
Blood Brain Barrier
33%
Microglia
33%
Growth Factor
33%
Cell Signaling
33%
Oncogene
33%
Chemokine Receptor
33%
CXCL5
33%
CXCL1
33%
Thymus and Activation Regulated Chemokine
33%
Proopiomelanocortin
33%
Cell Oncogene
33%
Epithelial Derived Neutrophil Activating Factor 78
33%
CCL2
33%
Tamoxifen
33%
Non-Rapid Eye Movement Sleep
22%
Rapid Eye Movement Sleep
22%
Cyclic Adenosine Monophosphate
14%
Elevated Plus Maze
11%
Locomotor Activity
11%
Wakefulness
11%
Dual Orexin Receptor Antagonist
11%
Sleep Disorder
11%
Diabetes Mellitus
11%
Neuronal Cell Death
7%
Orexin
7%
Behavior (Neuroscience)
7%
Protein Kinase A
7%
Amino Acid
7%
Protein Precursor
7%
Glutamic Acid
7%
Cell Viability
7%
Orexin-A
7%
Cerebral Cortex
7%
Orexin B
7%
Forskolin
7%
Phosphodiesterase Inhibitor
7%
H-89
7%
Rolipram
7%
Amino Terminal Sequence
7%
Hippocampus
7%
Posttranslational Modification
7%
Medicine and Dentistry
Platelet Derived Growth Factor
100%
Pericyte
100%
Brain Pericyte
71%
Chemokine
42%
Platelet Derived Growth Factor Receptor
42%
Lipopolysaccharide
42%
Platelet Derived Growth Factor BB
42%
High Fat Food
28%
Energy Metabolism
28%
Bone Marrow Derived Macrophage
28%
Hypothalamus
28%
Microglia
14%
Signal Transduction
14%
Calcium Calmodulin Dependent Protein Kinase
14%
Western Blotting
14%
Cytokine
14%
Chemokine Receptor
14%
Chronic Inflammation
14%
Gene Expression
14%
Serositis
14%
Body Weight Gain
14%
Monocyte Chemotactic Protein 1
14%
Tamoxifen
14%
Thymus and Activation Regulated Chemokine
14%
Proopiomelanocortin
14%
Cell Oncogene
14%
Epithelial Derived Neutrophil Activating Factor 78
14%
Mitogen-Activated Protein Kinase
14%
Co-Stimulation
14%
Growth Factor
14%
Blood Brain Barrier
14%
Oncogene C Fos
14%
Energy Consumption
14%
Macrophage
14%
Pathophysiology
14%
Norfloxacin
14%
Oncogene
14%
Messenger RNA
14%