Takuya Okada

2024

Development of Benziodarone Analogues with Enhanced Potency for Selective Binding to Transthyretin in Human Plasma

Mizuguchi, M., Nakagawa, Y., Yokoyama, T., Okada, T., Fujii, K., Takahashi, K., Luan, N. N. T., Nabeshima, Y., Kanamitsu, K., Nakagawa, S., Yamakawa, S., Ueda, M., Ando, Y. & Toyooka, N., 2024/05/09, In: Journal of Medicinal Chemistry. 67, 9, p. 6987-7005 19 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

2 被引用数 (Scopus)

Synthesis of 8-epi-L-swainsonine, related C6 alkylated derivatives and their α-L-rhamnosidase inhibition

Shimadate, Y., Oshima, S., Kasamatsu, N., Yamamoto, S., Taguchi, A., Nash, R. J., Fleet, G. W. J., Okada, T., Toyooka, N. & Kato, A., 2024/03/01, In: Tetrahedron Letters. p. 155008

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

1 被引用数 (Scopus)

Targeting Pancreatic Cancer with Novel Nicolaioidesin C Derivatives: Molecular Mechanism, In Vitro, and In Vivo Evaluations

Yamazaki, T., Phan, N. D., Maneenet, J., Yamagishi, M., Nishikawa, Y., Okada, T., Okumura, T., Toyooka, N., Fujii, T. & Awale, S., 2024/08/22, In: Journal of Medicinal Chemistry. 67, 16, p. 14313-14328 16 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

2023

Benziodarone and 6-hydroxybenziodarone are potent and selective inhibitors of transthyretin amyloidogenesis

Mizuguchi, M., Yokoyama, T., Okada, T., Nakagawa, Y., Fujii, K., Nabeshima, Y. & Toyooka, N., 2023/07/15, In: Bioorganic and Medicinal Chemistry. 90, 117370.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

5 被引用数 (Scopus)

Concise Total Synthesis of rac-Betuphenone F

Luan, N. N. T., Okada, T. & Toyooka, N., 2023/03/21, In: European Journal of Organic Chemistry. 26, 12, e202300047.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

1 被引用数 (Scopus)

Design, synthesis, structure–activity relationship studies, and evaluation of novel GLS1 inhibitors

Jo, M., Koizumi, K., Suzuki, M., Kanayama, D., Watanabe, Y., Gouda, H., Mori, H., Mizuguchi, M., Obita, T., Nabeshima, Y., Toyooka, N. & Okada, T., 2023/05/01, In: Bioorganic and Medicinal Chemistry Letters. 87, 129266.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

2 被引用数 (Scopus)

Design and pharmacological chaperone effects of N-(4'-phenylbutyl)-DAB derivatives targeting the lipophilic pocket of lysosomal acid α-glucosidase

Kato, A., Nakagome, I., Kise, M., Yoshimura, K., Tanaka, N., Nash, R. J., Fleet, G. W. J., Kobayashi, Y., Ikeda, H., Okada, T. & Toyooka, N., 2023/07/13, In: Journal of Medicinal Chemistry. 66, 13, p. 9023-9039 17 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

4 被引用数 (Scopus)

Design and structural optimization of thiadiazole derivatives with potent GLS1 inhibitory activity

Okada, T., Yamabe, K., Jo, M., Sakajiri, Y., Shibata, T., Sawada, R., Yamanishi, Y., Kanayama, D., Mori, H., Mizuguchi, M., Obita, T., Nabeshima, Y., Koizumi, K. & Toyooka, N., 2023/09/01, In: Bioorganic and Medicinal Chemistry Letters. 93, 129438.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

1 被引用数 (Scopus)

Nicolaioidesin C: An Antiausterity Agent Shows Promising Antitumor Activity in a Pancreatic Cancer Xenograft Mouse Model

Phan, N. D., Omar, A. M., Takahashi, I., Baba, H., Okumura, T., Imura, J., Okada, T., Toyooka, N., Fujii, T. & Awale, S., 2023/06/23, In: Journal of Natural Products. 86, 6, p. 1402-1410 9 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

4 被引用数 (Scopus)

Rafoxanide, a salicylanilide anthelmintic, interacts with human plasma protein transthyretin

Yokoyama, T., Mizuguchi, M., Nabeshima, Y., Nakagawa, Y., Okada, T., Toyooka, N. & Kusaka, K., 2023/11, In: FEBS Journal. 290, 21, p. 5158-5170 13 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

1 被引用数 (Scopus)

Resting phase-administration of lemborexant ameliorates sleep and glucose tolerance in type 2 diabetic mice

Tsuneki, H., Sugiyama, M., Sato, K., Ito, H., Nagai, S., Kon, K., Wada, T., Kobayashi, N., Okada, T., Toyooka, N., Kawasaki, M., Ito, T., Otsubo, R., Okuzaki, D., Yasui, T. & Sasaoka, T., 2023/12/15, In: European Journal of Pharmacology. 961, 176190.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

Targeting Pancreatic Cancer with Novel Plumbagin Derivatives: Design, Synthesis, Molecular Mechanism, In Vitro and In Vivo Evaluation

Awale, S., Baba, H., Phan, N. D., Kim, M. J., Maneenet, J., Sawaki, K., Kanda, M., Okumura, T., Fujii, T., Okada, T., Maruyama, T., Okada, T. & Toyooka, N., 2023/06/22, In: Journal of Medicinal Chemistry. 66, 12, p. 8054-8065

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

8 被引用数 (Scopus)

2022

A New Method for Albuminuria Measurement Using a Specific Reaction between Albumin and the Luciferin of the Firefly Squid Watasenia scintillans

Ishimoto, T., Okada, T., Fujisaka, S., Yagi, K., Tobe, K., Toyooka, N. & Mori, H., 2022/08, In: International Journal of Molecular Sciences. 23, 15, 8342.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

2 被引用数 (Scopus)

Chlorinated Naringenin Analogues as Potential Inhibitors of Transthyretin Amyloidogenesis

Mizuguchi, M., Nakagawa, Y., Inui, K., Katayama, W., Sawai, Y., Shimane, A., Kitakami, R., Okada, T., Nabeshima, Y., Yokoyama, T., Kanamitsu, K., Nakagawa, S. & Toyooka, N., 2022/12/22, In: Journal of Medicinal Chemistry. 65, 24, p. 16218-16233 16 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

7 被引用数 (Scopus)

Coupling of acceptor-substituted diazo compounds and tertiary thioamides: synthesis of enamino carbonyl compounds and their pharmacological evaluation

Secka, J., Pal, A., Acquah, F. A., Mooers, B. H. M., Karki, A. B., Mahjoub, D., Fakhr, M. K., Wallace, D. R., Okada, T., Toyooka, N., Kuta, A., Koduri, N., Herndon, D., Roberts, K. P., Wang, Z., Hileman, B., Rajagopal, N. & Hussaini, S. R., 2022/07/05, In: RSC Advances. 12, 30, p. 19431-19444 14 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

2 被引用数 (Scopus)

Design and synthesis of novel pipernonaline derivatives as anti-austerity agents against human pancreatic cancer PANC-1 cells

Okada, T., Chino, Y., Yokoyama, K., Fujihashi, Y., Duy Phan, N., Maneenet, J., Prudhvi, L., Awale, S. & Toyooka, N., 2022/10/01, In: Bioorganic and Medicinal Chemistry. 71, 116963.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

6 被引用数 (Scopus)

Design and synthesis of pyrido[2,3-d]pyrimidine derivatives for a novel PAC1 receptor antagonist

Takasaki, I., Watanabe, A., Okada, T., Kanayama, D., Nagashima, R., Shudo, M., Shimodaira, A., Nunomura, K., Lin, B., Watanabe, Y., Gouda, H., Miyata, A., Kurihara, T. & Toyooka, N., 2022/03/05, In: European Journal of Medicinal Chemistry. 231, 114160.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

7 被引用数 (Scopus)

Discovery and Structure-Based Optimization of Novel Atg4B Inhibitors for the Treatment of Castration-Resistant Prostate Cancer

Kudo, Y., Endo, S., Fujita, M., Ota, A., Kamatari, Y. O., Tanaka, Y., Ishikawa, T., Ikeda, H., Okada, T., Toyooka, N., Fujimoto, N., Matsunaga, T. & Ikari, A., 2022/03/24, In: Journal of Medicinal Chemistry. 65, 6, p. 4878-4892 15 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

7 被引用数 (Scopus)

Discovery of pimozide derivatives as novel T-type calcium channel inhibitors with little binding affinity to dopamine D₂ receptors for treatment of somatic and visceral pain

Kasanami, Y., Ishikawa, C., Kino, T., Chonan, M., Toyooka, N., Takashima, Y., Iba, Y., Sekiguchi, F., Tsubota, M., Ohkubo, T., Yoshida, S., Kawase, A., Okada, T. & Kawabata, A., 2022/12/05, In: European Journal of Medicinal Chemistry. 243, 114716.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

5 被引用数 (Scopus)

Divergent synthesis of decahydroquinoline-type poison-frog alkaloids.

寄稿の翻訳タイトル: Divergent synthesis of decahydroquinoline-type poison-frog alkaloids.Takashima, K., Okada, T., Kato, A., Yamasaki, Y., Sugouchi, T., Akanuma, S.-I., Kubo, Y., Hosoya, K.-I., Morita, H., Ito, T., Kodama, T., Tanabe, G. & Toyooka, N., 2022/02, In: ChemistrySelect. 7, 5

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

3 被引用数 (Scopus)

Small-molecule non-peptide antagonists of the PACAP receptor attenuate acute restraint stress-induced anxiety-like behaviors in mice

Shintani, Y., Yamano, Y., kuta, M., Takeshita, R., Takuma, K., Okada, T., Toyooka, N., Takasaki, I., Miyata, A., Kurihara, T., Hashimoto, H. & Hayata-Takano, A., 2022/11/26, In: Biochemical and Biophysical Research Communications. 631, p. 146-151 6 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

4 被引用数 (Scopus)

Structure-activity relationship study of 4′-O-methylgrynullarin derivatives for the development of novel anticancer agents based on anti-austerity strategy

Thanh Luan, N. N., Okada, T., Arata, R., Prudhvi, L., Miyaguchi, M., Kodama, Y., Awale, S. & Toyooka, N., 2022/09/10, In: Tetrahedron. 122, 132931.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

7 被引用数 (Scopus)

Total Synthesis of 4’-O-Methylgrynullarin and Related Isoflavone Natural Products

Okada, T., Ngoc Thanh Luan, N., Arata, R., Awale, S. & Toyooka, N., 2022/04/21, In: ChemistrySelect. 7, 15, e202201136.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

7 被引用数 (Scopus)

2021

Anti-austerity activity of thai medicinal plants: Chemical constituents and anti-pancreatic cancer activities of kaempferia parviflora

Sun, S., Kim, M. J., Dibwe, D. F., Omar, A. M., Athikomkulchai, S., Phrutivorapongkul, A., Okada, T., Tsuge, K., Toyooka, N. & Awale, S., 2021/02, In: Plants. 10, 2, p. 1-12 12 p., 229.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

14 被引用数 (Scopus)

Divergent Syntheses of Pumiliotoxin-Type Poison-Frog Alkaloids

Okada, T., Ozaki, T., Yamamoto, T., Kasahara, H., Kawasaki, M. & Toyooka, N., 2021/02/24, In: ChemistrySelect. 6, 8, p. 1939-1945 7 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

3 被引用数 (Scopus)

Inhibitory activities of anthraquinone and xanthone derivatives against transthyretin amyloidogenesis

Kitakami, R., Inui, K., Nakagawa, Y., Sawai, Y., Katayama, W., Yokoyama, T., Okada, T., Kanamitsu, K., Nakagawa, S., Toyooka, N. & Mizuguchi, M., 2021/08/15, In: Bioorganic and Medicinal Chemistry. 44, 116292.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

5 被引用数 (Scopus)

Total synthesis of decahydroquinoline poison frog alkaloids ent-cis-195a and cis-211a

Okada, T., Wu, N., Takashima, K., Ishimura, J., Morita, H., Ito, T., Kodama, T., Yamasaki, Y., Akanuma, S. I., Kubo, Y., Hosoya, K. I., Tsuneki, H., Wada, T., Sasaoka, T., Shimizu, T., Sakai, H., Dwoskin, L. P., Hussaini, S. R., Saporito, R. A. & Toyooka, N., 2021/12/01, In: Molecules. 26, 24, 7529.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

5 被引用数 (Scopus)

2020

A divergent entry to 1,2,3,9-tetrahydroxyquinolizidines

Okada, T., Ozaki, T., Kato, A., Adachi, I. & Toyooka, N., 2020/06/18, In: Tetrahedron Letters. 61, 25, 152030.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

Cystitis-related bladder pain involves atp-dependent hmgb1 release from macrophages and its downstream h₂s/ca_v3.2 signaling in mice

Hiramoto, S., Tsubota, M., Yamaguchi, K., Okazaki, K., Sakaegi, A., Toriyama, Y., Tanaka, J., Sekiguchi, F., Ishikura, H., Wake, H., Nishibori, M., Nguyen, H. D., Okada, T., Toyooka, N. & Kawabata, A., 2020/08, In: Cells. 9, 8, p. 1-20 20 p., 1748.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

31 被引用数 (Scopus)

Development of Novel AKR1C3 Inhibitors as New Potential Treatment for Castration-Resistant Prostate Cancer

Endo, S., Oguri, H., Segawa, J., Kawai, M., Hu, D., Xia, S., Okada, T., Irie, K., Fujii, S., Gouda, H., Iguchi, K., Matsukawa, T., Fujimoto, N., Nakayama, T., Toyooka, N., Matsunaga, T. & Ikari, A., 2020/09/24, In: Journal of Medicinal Chemistry. 63, 18, p. 10396-10411 16 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

32 被引用数 (Scopus)

Essential role of Ca_v3.2 T-type calcium channels in butyrate-induced colonic pain and nociceptor hypersensitivity in mice

Tsubota, M., Matsui, K., Nakano, M., Kajitani, R., Ishii, Y., Tomochika, K., Nishikawa, Y., Fukushi, S., Yamagata, A., Sekiguchi, F., Okada, T., Toyooka, N. & Kawabata, A., 2020/11/15, In: European Journal of Pharmacology. 887, 173576.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

7 被引用数 (Scopus)

Synthesis and olfactory evaluation of optically active β-alkyl substituted γ-lactones and whiskey lactone analogues

Kawasaki, M., Kato, D., Okada, T., Morita, Y., Tanaka, Y. & Toyooka, N., 2020/03/20, In: Tetrahedron. 76, 12, 130984.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

3 被引用数 (Scopus)

Synthesis of a novel and potent small-molecule antagonist of PAC1 receptor for the treatment of neuropathic pain

Takasaki, I., Ogashi, H., Okada, T., Shimodaira, A., Hayakawa, D., Watanabe, A., Miyata, A., Kurihara, T., Gouda, H. & Toyooka, N., 2020/01/15, In: European Journal of Medicinal Chemistry. 186, 111902.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

17 被引用数 (Scopus)

2019

Critical role of Ca_v3.2 T-type calcium channels in the peripheral neuropathy induced by bortezomib, a proteasome-inhibiting chemotherapeutic agent, in mice

Tomita, S., Sekiguchi, F., Deguchi, T., Miyazaki, T., Ikeda, Y., Tsubota, M., Yoshida, S., Nguyen, H. D., Okada, T., Toyooka, N. & Kawabata, A., 2019/02/01, In: Toxicology. 413, p. 33-39 7 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

46 被引用数 (Scopus)

Design and synthesis of functionalized coumarins as potential anti-austerity agents that eliminates cancer cells' tolerance to nutrition starvation

Awale, S., Okada, T., Dibwe, D. F., Maruyama, T., Takahara, S., Okada, T., Endo, S. & Toyooka, N., 2019/07/15, In: Bioorganic and Medicinal Chemistry Letters. 29, 14, p. 1779-1784 6 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

22 被引用数 (Scopus)

Identification and total synthesis of two previously unreported odd-chain bis-methylene-interrupted fatty acids with a terminal olefin that activate protein phosphatase, Mg² ⁺/Mn² ⁺-Dependent 1A (PPM1A) in Ovaries of the Limpet Cellana toreuma

Kawashima, H., Toyooka, N., Okada, T., Nguyen, H. D., Nishikawa, Y., Miura, Y., Inoue, N. & Kimura, K. I., 2019, In: Marine Drugs. 17, 7, 410.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

5 被引用数 (Scopus)

Synthetic Studies on Nodulisporic Acids with Multi-substituted Indole Skeleton

Okada, T., 2019, In: Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry. 77, 8, p. 845-848 4 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

The novel small-molecule antagonist of PAC1 receptor attenuates formalin-induced inflammatory pain behaviors in mice

Takasaki, I., Nakamura, K., Shimodaira, A., Watanabe, A., Du Nguyen, H., Okada, T., Toyooka, N., Miyata, A. & Kurihara, T., 2019/02, In: Journal of Pharmacological Sciences. 139, 2, p. 129-132 4 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

13 被引用数 (Scopus)

2018

Blockade of T-type calcium channels by 6-prenylnaringenin, a hop component, alleviates neuropathic and visceral pain in mice

Sekiguchi, F., Fujita, T., Deguchi, T., Yamaoka, S., Tomochika, K., Tsubota, M., Ono, S., Horaguchi, Y., Ichii, M., Ichikawa, M., Ueno, Y., Koike, N., Tanino, T., Nguyen, H. D., Okada, T., Nishikawa, H., Yoshida, S., Ohkubo, T., Toyooka, N. & Murata, K. & 2 others, Matsuda, H. & Kawabata, A., 2018/08, In: Neuropharmacology. 138, p. 232-244 13 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

25 被引用数 (Scopus)

Design and synthesis of novel anti-hyperalgesic agents based on 6-prenylnaringenin as the T-type calcium channel blockers

Du Nguyen, H., Okada, T., Kitamura, S., Yamaoka, S., Horaguchi, Y., Kasanami, Y., Sekiguchi, F., Tsubota, M., Yoshida, S., Nishikawa, H., Kawabata, A. & Toyooka, N., 2018/08/15, In: Bioorganic and Medicinal Chemistry. 26, 15, p. 4410-4427 18 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

17 被引用数 (Scopus)

In silico screening identified novel small-molecule antagonists of PAC1 receptors

Takasaki, I., Watanabe, A., Yokai, M., Watanabe, Y., Hayakawa, D., Nagashima, R., Fukuchi, M., Okada, T., Toyooka, N., Miyata, A., Gouda, H. & Kurihara, T., 2018/04, In: Journal of Pharmacology and Experimental Therapeutics. 365, 1, p. 1-8 8 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

27 被引用数 (Scopus)

Synthesis of 8-deoxypumiliotoxin 193H and 9-deoxyhomopumiliotoxin 207O

Okada, T., Yamamoto, T., Kato, D., Kawasaki, M., Saporito, R. A. & Toyooka, N., 2018/10/17, In: Tetrahedron Letters. 59, 42, p. 3797-3800 4 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

9 被引用数 (Scopus)

2016

Synthesis of new tricyclic thiolactams as potent antitumor agent for pancreatic cancer

Okada, T., Minehira, D., Takada, M., Urata, H., Kato, A., Adachi, I., Kurashima, Y., Kaji, S., Ogura, T., Chiba, S., Esumi, H. & Toyooka, N., 2016/06/01, In: Bioorganic and Medicinal Chemistry Letters. 26, 11, p. 2577-2579 3 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

9 被引用数 (Scopus)

2015

Enantiodivergent strategy for the synthesis of polyhydroxylated pyrrolizidines and evaluation of their inhibitory activities against glycosidases

Minehira, D., Okada, T., Iwaki, R., Kato, A., Adachi, I. & Toyooka, N., 2015/01/08, In: Tetrahedron Letters. 56, 2, p. 331-334 4 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

4 被引用数 (Scopus)

2014

Discovery of novel adenylyl cyclase inhibitor by cell-based screening

Mano, H., Ishimoto, T., Okada, T., Toyooka, N. & Mori, H., 2014/10/01, In: Biological and Pharmaceutical Bulletin. 37, 10, p. 1689-1693 5 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

3 被引用数 (Scopus)

岡田 卓哉

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岡田卓哉