Takashi Okitsu

2024

8-Iodoisoquinolinone, a Conformationally Rigid Highly Reactive 2-Iodobenzamide Catalyst for the Oxidation of Alcohols by Hypervalent Iodine

Yakura, T., Fujiwara, T., Asakubo, K., Perumalla, H. N. L., Uzu, M., Okitsu, T., Kasama, K. & Nambu, H., 2024, In: Chemical and Pharmaceutical Bulletin. 72, 2, p. 234-239 6 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

Boron Trifluoride-Mediated Domino Dehydration/Electrophilic Cyclization of Silylalkynols Leading to 2,3-Fused Tricyclic Benzofulvenes

Okitsu, T., Yoshikawa, T., Morohashi, M., Aoki, K., Yakura, T., Sakata, K. & Hatano, M., 2024/03/01, In: Organic Letters. 26, 8, p. 1652-1656 5 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Dearomative Intramolecular Diels–Alder/Sulfur Extrusion Reaction of Thiophenes with Alkynes Using peri-Substituted Naphthalene as a Tether

Okitsu, T., Shinohara, Y., Luo, H., Hatano, M. & Yakura, T., 2024/02/16, In: Chemistry - An Asian Journal. 19, 4, e202301031.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

1 被引用数 (Scopus)

Efficient and Environmentally Benign Oxidative Cleavage of Pyrrolidine-2-methanols to γ-Lactams Using 2-Iodobenzamide as a Catalyst and Oxone

Perumalla, H. N. L., Fujiwara, T., Okada, M., Asakubo, K., Okitsu, T., Kasama, K., Nambu, H. & Yakura, T., 2024/01/01, In: Chemical and Pharmaceutical Bulletin. 72, 1, p. 75-79 5 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

2023

Characterization of retinal chromophore and protonated Schiff base in Thermoplasmatales archaeon heliorhodopsin using solid-state NMR spectroscopy

Suzuki, S., Kumagai, S., Nagashima, T., Yamazaki, T., Okitsu, T., Wada, A., Naito, A., Katayama, K., Inoue, K., Kandori, H. & Kawamura, I., 2023/05, In: Biophysical Chemistry. 296, 106991.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

6 被引用数 (Scopus)

Solid-state NMR for the characterization of retinal chromophore and Schiff base in TAT rhodopsin embedded in membranes under weakly acidic conditions

Arikawa, S., Sugimoto, T., Okitsu, T., Wada, A., Katayama, K., Kandori, H. & Kawamura, I., 2023, In: Biophysics and physicobiology. 20, e201017.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

5 被引用数 (Scopus)

一価のカチオン性ヨウ素反応剤を用いるアルキンの求電子的環化反応

Okitsu, T., 2023, In: Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry. 81, 8, p. 787-797 11 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

2022

Photoreaction Pathways of Bacteriorhodopsin and Its D96N Mutant as Revealed by in Situ Photoirradiation Solid-State NMR

Shigeta, A., Otani, Y., Miyasa, R., Makino, Y., Kawamura, I., Okitsu, T., Wada, A. & Naito, A., 2022/03, In: Membranes. 12, 3, 279.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

3 被引用数 (Scopus)

Rapid Synthesis of Polycyclic Aromatic Compounds by Iodocyclization of Ynamides

Okitsu, T., Itoh, M., Inui, A., Muta, E., Nakamoto, R., Adachi, Y., Wada, A. & Hatano, M., 2022/08, In: Asian Journal of Organic Chemistry. 11, 8, e202200275.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

6 被引用数 (Scopus)

2021

Concise preparation and biological evaluations of 9-cis-retinoic acid analogues having an aromatic ring

Okitsu, T., Iwatsuka, K., Nakagawa, K., Okano, T. & Wada, A., 2021, In: Heterocycles. 103, 1

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

1 被引用数 (Scopus)

Structure of a retinal chromophore of dark-adapted middle rhodopsin as studied by solid-state nuclear magnetic resonance spectroscopy

Kawamura, I., Seki, H., Tajima, S., Makino, Y., Shigeta, A., Okitsu, T., Wada, A., Naito, A. & Sudo, Y., 2021, In: Biophysics and physicobiology. 18, p. 177-185 9 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

6 被引用数 (Scopus)

2020

A dearomative ipso-iodocyclization/desymmetrization sequence leading to optically active tricyclic piperazine scaffolds

Okitsu, T., Horike, A., Shimazawa, N. & Wada, A., 2020/05/14, In: Organic and Biomolecular Chemistry. 18, 18, p. 3501-3511 11 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

12 被引用数 (Scopus)

Synthesis of one double bond-inserted retinal analogs and their binding experiments with opsins: Preparation of novel red-shifted channelrhodopsin variants

Okitsu, T., Yamano, Y., Shen, Y. C., Sasaki, T., Kobayashi, Y., Morisawa, S., Yamashita, T., Imamoto, Y., Shichida, Y. & Wada, A., 2020/03/01, In: Chemical and Pharmaceutical Bulletin. 68, 3, p. 265-272 8 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

4 被引用数 (Scopus)

Visual adaptation of opsin genes to the aquatic environment in sea snakes

Seiko, T., Kishida, T., Toyama, M., Hariyama, T., Okitsu, T., Wada, A., Toda, M., Satta, Y. & Terai, Y., 2020/12, In: BMC Evolutionary Biology. 20, 1, 158.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

4 被引用数 (Scopus)

Ynamides enabled 6-, 7-, and 8-endo-dig iodocyclization of ethoxyethyl ethers: rapid construction of medium-sized oxacycles at room temperature

Okitsu, T., Namura, A., Kondo, S., Tada, S., Yanagida, M. & Wada, A., 2020/03/21, In: Organic Chemistry Frontiers. 7, 6, p. 879-884 6 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

20 被引用数 (Scopus)

2018

Production of a Light-Gated Proton Channel by Replacing the Retinal Chromophore with Its Synthetic Vinylene Derivative

Takayama, R., Kaneko, A., Okitsu, T., Tsunoda, S. P., Shimono, K., Mizuno, M., Kojima, K., Tsukamoto, T., Kandori, H., Mizutani, Y., Wada, A. & Sudo, Y., 2018/06/07, In: Journal of Physical Chemistry Letters. 9, 11, p. 2857-2862 6 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

13 被引用数 (Scopus)

Red-Tuning of the Channelrhodopsin Spectrum Using Long Conjugated Retinal Analogues

Shen, Y. C., Sasaki, T., Matsuyama, T., Yamashita, T., Shichida, Y., Okitsu, T., Yamano, Y., Wada, A., Ishizuka, T., Yawo, H. & Imamoto, Y., 2018/09/25, In: Biochemistry. 57, 38, p. 5544-5556 13 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

11 被引用数 (Scopus)

Retinal Configuration of ppR Intermediates Revealed by Photoirradiation Solid-State NMR and DFT

Makino, Y., Kawamura, I., Okitsu, T., Wada, A., Kamo, N., Sudo, Y., Ueda, K. & Naito, A., 2018/07/03, In: Biophysical Journal. 115, 1, p. 72-83 12 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

12 被引用数 (Scopus)

Silyl Group-Directed 6-exo-dig Iodocyclization of Homopropargylic Carbamates and Amides

Okitsu, T., Nakahigashi, H., Sugihara, R., Fukuda, I., Tsuji, S., In, Y. & Wada, A., 2018/12/12, In: Chemistry - A European Journal. 24, 70, p. 18638-18642 5 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

5 被引用数 (Scopus)

2017

3-Methylene-4-amido-1,2-diazetidine as a Formal 1,4-Dipole Precursor: Lewis Acid-Catalyzed Nucleophilic Addition with Silylated Nucleophiles

Okitsu, T., Kobayashi, K., Kan, R., Yoshida, Y., Matsui, Y. & Wada, A., 2017/09/01, In: Organic Letters. 19, 17, p. 4592-4595 4 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

13 被引用数 (Scopus)

Alternative formation of red-shifted channelrhodopsins: Noncovalent incorporation with retinal-based enamine-type schiff bases and mutated channelopsin

Okitsu, T., Matsuyama, T., Yamashit, T., Ishizuk, T., Yawo, H., Imamoto, Y., Shichid, Y. & Wada, A., 2017, In: Chemical and Pharmaceutical Bulletin. 65, 4, p. 356-358 3 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

3 被引用数 (Scopus)

Solid-state nuclear magnetic resonance structural study of the retinal-binding pocket in sodium ion pump rhodopsin

Shigeta, A., Ito, S., Inoue, K., Okitsu, T., Wada, A., Kandori, H. & Kawamura, I., 2017/01/31, In: Biochemistry. 56, 4, p. 543-550 8 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

27 被引用数 (Scopus)

Visual adaptation in Lake Victoria cichlid fishes: Depth-related variation of color and scotopic opsins in species from sand/mud bottoms

Terai, Y., Miyagi, R., Aibara, M., Mizoiri, S., Imai, H., Okitsu, T., Wada, A., Takahashi-Kariyazono, S., Sato, A., Tichy, H., Mrosso, H. D. J., Mzighani, S. I. & Okada, N., 2017/08/22, In: BMC Evolutionary Biology. 17, 1, 200.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

25 被引用数 (Scopus)

2016

Convergent synthesis of dronedarone, an antiarrhythmic agent

Okitsu, T., Ogasahara, M. & Wada, A., 2016, In: Chemical and Pharmaceutical Bulletin. 64, 8, p. 1149-1153 5 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

10 被引用数 (Scopus)

2015

Characterization of photo-intermediates in the photo-reaction pathways of a bacteriorhodopsin Y185F mutant using in situ photo-irradiation solid-state NMR spectroscopy

Oshima, K., Shigeta, A., Makino, Y., Kawamura, I., Okitsu, T., Wada, A., Tuzi, S., Iwasa, T. & Naito, A., 2015/06/26, In: Photochemical and Photobiological Sciences. 14, 9, p. 1694-1702 9 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

10 被引用数 (Scopus)

Identical hydrogen-bonding strength of the retinal Schiff base between primate green- and red-sensitive pigments: New insight into color tuning mechanism

Katayama, K., Okitsu, T., Imai, H., Wada, A. & Kandori, H., 2015/04/02, In: Journal of Physical Chemistry Letters. 6, 7, p. 1130-1133 4 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

17 被引用数 (Scopus)

2014

Color-discriminating retinal configurations of sensory rhodopsin I by photo-irradiation solid-state NMR spectroscopy

Yomoda, H., Makino, Y., Tomonaga, Y., Hidaka, T., Kawamura, I., Okitsu, T., Wada, A., Sudo, Y. & Naito, A., 2014/07/01, In: Angewandte Chemie - International Edition. 53, 27, p. 6960-6964 5 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

19 被引用数 (Scopus)

Inhibition of lysine-specific demethylase 1 by the acyclic diterpenoid geranylgeranoic acid and its derivatives

Sakane, C., Okitsu, T., Wada, A., Sagami, H. & Shidoji, Y., 2014/01/31, In: Biochemical and Biophysical Research Communications. 444, 1, p. 24-29 6 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

28 被引用数 (Scopus)

Iodocyclization of Ethoxyethyl Ethers to Ynamides: An Immediate Construction to Benzo[b]furans

Okitsu, T., Nakata, K., Nishigaki, K., Michioka, N., Karatani, M. & Wada, A., 2014/06/20, In: Journal of Organic Chemistry. 79, 12, p. 5914-5920 7 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

46 被引用数 (Scopus)

2013

Large spectral change due to amide modes of a β-sheet upon the formation of an early photointermediate of middle rhodopsin

Furutani, Y., Okitsu, T., Reissig, L., Mizuno, M., Homma, M., Wada, A., Mizutani, Y. & Sudo, Y., 2013/04/04, In: Journal of Physical Chemistry B. 117, 13, p. 3449-3458 10 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

6 被引用数 (Scopus)

Menadione (vitamin K₃) is a catabolic product of oral phylloquinone (vitamin K₁) in the intestine and a circulating precursor of tissue menaquinone-4 (vitamin K₂) in rats

Hirota, Y., Tsugawa, N., Nakagawa, K., Suhara, Y., Tanaka, K., Uchino, Y., Takeuchi, A., Sawada, N., Kamao, M., Wada, A., Okitsu, T. & Okano, T., 2013/11/15, In: Journal of Biological Chemistry. 288, 46, p. 33071-33080 10 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

112 被引用数 (Scopus)

Solid-state NMR ¹³C and ¹⁵N resonance assignments of a seven-transmembrane helical protein Anabaena Sensory Rhodopsin

Wang, S., Shi, L., Okitsu, T., Wada, A., Brown, L. S. & Ladizhansky, V., 2013/10, In: Biomolecular NMR Assignments. 7, 2, p. 253-256 4 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

23 被引用数 (Scopus)

Solid-state NMR spectroscopy structure determination of a lipid-embedded heptahelical membrane protein

Wang, S., Munro, R. A., Shi, L., Kawamura, I., Okitsu, T., Wada, A., Kim, S. Y., Jung, K. H., Brown, L. S. & Ladizhansky, V., 2013/10, In: Nature Methods. 10, 10, p. 1007-1012 6 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

197 被引用数 (Scopus)

Substituent effect of bis(pyridines)iodonium complexes as iodinating reagents: Control of the iodocyclization/oxidation process

Okitsu, T., Yumitate, S., Sato, K., In, Y. & Wada, A., 2013/04/15, In: Chemistry - A European Journal. 19, 16, p. 4992-4996 5 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

56 被引用数 (Scopus)

2012

Correlation between nuptial colors and visual sensitivities tuned by opsins leads to species richness in sympatric Lake Victoria cichlid fishes

Miyagi, R., Terai, Y., Aibara, M., Sugawara, T., Imai, H., Tachida, H., Mzighani, S. I., Okitsu, T., Wada, A. & Okada, N., 2012/11, In: Molecular Biology and Evolution. 29, 11, p. 3281-3296 16 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

44 被引用数 (Scopus)

Reaction of acetals with various carbon nucleophiles under non-acidic conditions: C-C bond formation via a pyridinium-type salt

Fujioka, H., Yahata, K., Hamada, T., Kubo, O., Okitsu, T., Sawama, Y., Ohnaka, T., Maegawa, T. & Kita, Y., 2012/02/06, In: Chemistry - An Asian Journal. 7, 2, p. 367-373 7 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

18 被引用数 (Scopus)

Structure-activity relationship of novel menaquinone-4 analogues: Modification of the side chain affects their biological activities

Suhara, Y., Hanada, N., Okitsu, T., Sakai, M., Watanabe, M., Nakagawa, K., Wada, A., Takeda, K., Takahashi, K., Tokiwa, H. & Okano, T., 2012/02/23, In: Journal of Medicinal Chemistry. 55, 4, p. 1553-1558 6 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

14 被引用数 (Scopus)

Tandem Migration-Carboalkoxylation of o-Isocyanophenyl Acetals Leading to Benzoxazoles

Okitsu, T., Nagase, K., Nishio, N. & Wada, A., 2012/02/03, In: Organic Letters. 14, 3, p. 708-711 4 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

23 被引用数 (Scopus)

2011

An active photoreceptor intermediate revealed by in situ photoirradiated solid-state NMR spectroscopy

Tomonaga, Y., Hidaka, T., Kawamura, I., Nishio, T., Ohsawa, K., Okitsu, T., Wada, A., Sudo, Y., Kamo, N., Ramamoorthy, A. & Naito, A., 2011/11/16, In: Biophysical Journal. 101, 10, p. L50-L52

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

26 被引用数 (Scopus)

Iodocyclization of hydroxylamine derivatives based on the control of oxidative aromatization leading to 2,5-dihydroisoxazoles and isoxazoles

Okitsu, T., Sato, K., Potewar, T. M. & Wada, A., 2011/05/06, In: Journal of Organic Chemistry. 76, 9, p. 3438-3449 12 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

51 被引用数 (Scopus)

Novel Iodocyclization Method Based on the Controlling of Oxidative Aromatization

Okitsu, T., 2011, In: Yakugaku Zasshi. 131, 9, p. 1323-1327 5 p.

研究成果: ジャーナルへの寄稿 › 総説 › 査読

Open Access

1 被引用数 (Scopus)

Replacement of the hydrophobic part of 9-cis-retinoic acid with cyclic terpenoid moiety results in RXR-selective agonistic activity

Okitsu, T., Sato, K., Iwatsuka, K., Sawada, N., Nakagawa, K., Okano, T., Yamada, S., Kakuta, H. & Wada, A., 2011/05/01, In: Bioorganic and Medicinal Chemistry. 19, 9, p. 2939-2949 11 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

9 被引用数 (Scopus)

2010

Efficient synthesis and biological evaluation of demethyl geranylgeranoic acid derivatives

Wada, A., Wang, F., Suhara, Y., Yamano, Y., Okitsu, T., Nakagawa, K. & Okano, T., 2010/08/15, In: Bioorganic and Medicinal Chemistry. 18, 16, p. 5795-5806 12 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

8 被引用数 (Scopus)

ipso-Iodocyclization of Ethoxyethyl Ethers to Alkynes at the ortho-Position: An Efficient Synthesis of Functionalized Spiro Compounds

Okitsu, T., Nakazawa, D., Kobayashi, A., Mizohata, M., In, Y., Ishida, T. & Wada, A., 2010, In: Synlett. 2, p. 203-206 4 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

37 被引用数 (Scopus)

Reagent-controlled oxidative aromatization in iodocyclization: Switchable access to dihydropyrazoles and pyrazoles

Okitsu, T., Sato, K. & Wada, A., 2010/08/06, In: Organic Letters. 12, 15, p. 3506-3509 4 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

84 被引用数 (Scopus)

Synthesis and biological evaluation of 9Z-retinoic acid analogs having 2-substituted benzo[b]furan

Okitsu, T., Nakazawa, D., Nakagawa, K., Okano, T. & Wada, A., 2010/03, In: Chemical and Pharmaceutical Bulletin. 58, 3, p. 418-422 5 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

10 被引用数 (Scopus)

2009

Mild and efficient deprotection of acetal-type protecting groups of hydroxyl functions by triethylsilyl triflate2,4,6-collidine combination

Fujioka, H., Kubo, O., Okamoto, K., Senami, K., Okitsu, T., Ohnaka, T., Sawama, Y. & Kita, Y., 2009/02/01, In: Heterocycles. 77, 2, p. 1089-1103 15 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読