年別のプロジェクト
研究者プロファイル
研究経歴
The major focus of my research is directed toward the discovery of an "anti-austerity strategy" based on anticancer agents. These agents are useful for the treatment of pancreatic cancer, for which there is no reliable treatment at present. Pancreatic cancers are clinically hypovascular and have inherent tolerance to nutrition starvation. Elimination of this tolerance is a new "Antiausterity strategy" in anticancer drug discovery. Visit the following page for the details. http://nddlab.weebly.com
研究室情報
研究室情報
For Prospective Graduate Students
We welcome motivated students who wish to pursue careers in natural product chemistry, drug discovery, and drug development. State-of-the-art facilities are available in our lab to conduct advanced research in natural product chemistry, chemical biology, and molecular biology. Each researcher will master the art of isolation and identification of bioactive natural compounds, structure elucidation using the most advanced computer-assisted Nuclear Magnetic Resonance (NMR) spectroscopy technologies, and advanced computational calculations (ECD and NMR). Our laboratory has established a unique NMR strategy based on a chemical biology approach to understand the underlying mechanisms of cancer cells, metabolomes, drug actions, and biomarker discovery. In addition, we investigate the mechanism of action of anticancer drugs against cell survival pathways, with particular emphasis on the PI3K/Akt/mTOR/autophagy pathways.
Our lab has extensive cross-disciplinary scientific collaborations with national and international groups. We welcome enthusiastic students who dream of achieving the highest level of pharmaceutical science, natural medicine, drug discovery, and contributing to better health in human society. We have an excellent research and learning environment and can develop new skills and ideas. Every undergraduate and graduate student in our laboratory can contribute sufficiently to publishing a paper in an international journal with their name as the first author.
学内職務経歴
和漢医薬学総合研究所 准教授 2015/04/01-2019/09/30
薬学・和漢系 准教授 2019/10/01-
和漢医薬学総合研究所 准教授 2019/10/01-
所属学会
研究概要
UN SDGに関連する専門知識
2015年に、国連 (UN) 加盟国は、貧困を終わらせ、地球を保護し、すべての人の繁栄を保証するための17の全世界での持続可能な開発目標 (SDG) に合意しました。この人物の研究は、次のSDGに貢献しています。
研究分野・キーワード
- 膵臓がん
- がん研究
- ケミカルバイオロジー
- がん生物学
- PI3/Akt/mTOR
- オートファジー
- アンチオーステリティ戦略
- メディシナルケミストリー
- 抗がん剤
- 核磁気共鳴分光法
- 栄養飢餓耐性
- NMR構造解明
- 天然物化学
フィンガープリント
- 1 類似のプロファイル
過去5年の共同研究と上位研究分野
プロジェクト
- 4 終了
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ADHDエピジェネティック動物モデルでの発症機構解明と和漢薬による予防治療法開発
Matsumoto, K. (PI), Awale, S. (CoI), 藤原, 博典 (CoI) & Hori, E. (CoI)
2015/04/01 → 2018/03/31
プロジェクト: 研究
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栄養飢餓耐性を有する膵臓がん細胞の代謝学的特徴および耐性関連バイオマーカーの探索
Awale, S. (PI) & Esumi, H. (CoI)
2012/04/01 → 2016/03/31
プロジェクト: 研究
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和漢薬'牛蒡子'成分アルクチゲニンから新規膵臓がん治療薬の開発
Tezuka, Y. (PI), Toyooka, N. (CoI) & Awale, S. (CoI)
2010/04/01 → 2013/03/31
プロジェクト: 研究
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Nicolaioidesin C: An Antiausterity Agent Shows Promising Antitumor Activity in a Pancreatic Cancer Xenograft Mouse Model
Phan, N. D., Omar, A. M., Takahashi, I., Baba, H., Okumura, T., Imura, J., Okada, T., Toyooka, N., Fujii, T. & Awale, S., 2023/06/23, In: Journal of Natural Products. 86, 6, p. 1402-1410 9 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
4 被引用数 (Scopus) -
New callistrilone epimers from Callistemon citrinus and their antiausterity activity against the PANC-1 human pancreatic cancer cell line
Tawila, A. M., Omar, A. M., Phan, N. D., Takahashi, I., Maneenet, J. & Awale, S., 2022/06/22, In: Tetrahedron Letters. 100, 153881.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
6 被引用数 (Scopus) -
Chemical constituents of Callistemon citrinus from Egypt and their antiausterity activity against PANC-1 human pancreatic cancer cell line
Tawila, A. M., Sun, S., Kim, M. J., Omar, A. M., Dibwe, D. F., Ueda, J. Y., Toyooka, N. & Awale, S., 2020/08/15, In: Bioorganic and Medicinal Chemistry Letters. 30, 16, 127352.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
19 被引用数 (Scopus) -
Ancistrolikokine E3, a 5,8′-Coupled Naphthylisoquinoline Alkaloid, Eliminates the Tolerance of Cancer Cells to Nutrition Starvation by Inhibition of the Akt/mTOR/Autophagy Signaling Pathway
Awale, S., Dibwe, D. F., Balachandran, C., Fayez, S., Feineis, D., Lombe, B. K. & Bringmann, G., 2018/10/26, In: Journal of Natural Products. 81, 10, p. 2282-2291 10 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
67 被引用数 (Scopus) -
Abietane diterpenes from Abies spectabilis and their anti-pancreatic cancer activity against the MIA PaCa-2 cell line
Phan, N. D., Omar, A. M., Sun, S., Maneenet, J., Dibwe, D. F., Sato, M., Kalauni, S. K., Toyooka, N., Fujii, T. & Awale, S., 2022/06/15, In: Bioorganic and Medicinal Chemistry Letters. 66, 128723.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access8 被引用数 (Scopus)
活動
- 1 編集作業