Shiro Watanabe

2024

Antibiotic effects on gut microbiota modulate diet-induced metabolic dysfunction-associated steatohepatitis development in C57BL/6 mice

Takano, S., Kani, K., Kasai, K., Igarashi, N., Kato, M., Goto, K., Matsuura, Y., Ichimura-Shimizu, M., Watanabe, S., Tsuneyama, K., Furusawa, Y. & Nagai, Y., 2024/08, In: Genes to Cells. 29, 8, p. 635-649 15 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Goreisan-induced modulation of fecal bile acid composition and gut microbiota in mice

Watanabe, S., Takahashi, K., Awale, S., Furusawa, Y., Tabuchi, Y., Nishidono, Y. & Tanaka, K., 2024, (受理済み/印刷中) In: Traditional & Kampo Medicine.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Hypothermia increases adenosine monophosphate and xanthosine monophosphate levels in the mouse hippocampus, preventing their reduction by global cerebral ischemia

Doshi, M., Natori, Y., Ishii, A., Saigusa, D., Watanabe, S., Hosoyamada, M. & Hirashima-Akae, Y., 2024/12, In: Scientific Reports. 14, 1, 3187.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

Impacts of liver macrophages, gut microbiota, and bile acid metabolism on the differences in iHFC diet-induced MASH progression between TSNO and TSOD mice

Igarashi, N., Kasai, K., Tada, Y., Kani, K., Kato, M., Takano, S., Goto, K., Matsuura, Y., Ichimura-Shimizu, M., Watanabe, S., Tsuneyama, K., Furusawa, Y. & Nagai, Y., 2024/07, In: Inflammation Research. 73, 7, p. 1081-1098 18 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

1 被引用数 (Scopus)

2023

Chemical-Enantiomeric Characterization and In-Vitro Biological Evaluation of the Essential Oils from Elsholtzia strobilifera (Benth.) Benth. and E. blanda (Benth.) Benth. from Nepal

Paudel, P. N., Satyal, P., Setzer, W. N., Awale, S., Watanabe, S., Maneenet, J., Satyal, R., Acharya, A., Phuyal, M. & Gyawali, R., 2023/07/01, In: Natural Product Communications. 18, 7

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

1 被引用数 (Scopus)

Impact of Vancomycin Treatment and Gut Microbiota on Bile Acid Metabolism and the Development of Non-Alcoholic Steatohepatitis in Mice

Kasai, K., Igarashi, N., Tada, Y., Kani, K., Takano, S., Yanagibashi, T., Usui-Kawanishi, F., Fujisaka, S., Watanabe, S., Ichimura-Shimizu, M., Takatsu, K., Tobe, K., Tsuneyama, K., Furusawa, Y. & Nagai, Y., 2023/02, In: International Journal of Molecular Sciences. 24, 4, 4050.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

6 被引用数 (Scopus)

Isoxanthohumol improves obesity and glucose metabolism via inhibiting intestinal lipid absorption with a bloom of Akkermansia muciniphila in mice

Watanabe, Y., Fujisaka, S., Morinaga, Y., Watanabe, S., Nawaz, A., Hatta, H., Kado, T., Nishimura, A., Bilal, M., Aslam, M. R., Honda, K., Nakagawa, Y., Softic, S., Hirabayashi, K., Nakagawa, T., Nagai, Y. & Tobe, K., 2023/11, In: Molecular Metabolism. 77, 101797.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

16 被引用数 (Scopus)

Uncovering the metabolomic effects of Kampo formulas using ¹H-NMR spectroscopy: A case study of goreisan

Awale, S., Jo, M., Watanabe, S., Shibahara, N. & Matsumoto, K., 2023/08, In: Traditional & Kampo Medicine. 10, 2, p. 142-149 8 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

2 被引用数 (Scopus)

Uncovering the metabolomic effects of Kampo formulas using 1H-NMR spectroscopy

Awale, S., Jo, M., Watanabe, S., Shibahara, N. & Matsumoto, K., 2023, In: Uncovering the metabolomic effects of Kampo formulas using 1H-NMR spectroscopy: A case study of goreisan..

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

2022

Dietary Cholic Acid Exacerbates Liver Fibrosis in NASH Model of Sprague–Dawley Rats Fed a High-Fat and High-Cholesterol Diet

Ichimura-Shimizu, M., Watanabe, S., Kashirajima, Y., Nagatomo, A., Wada, H., Tsuneyama, K. & Omagari, K., 2022/08, In: International Journal of Molecular Sciences. 23, 16, 9268.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

11 被引用数 (Scopus)

Fluctuations in the chemical constituents of Panax ginseng subterranean tissues with cultivation duration

Nishidono, Y., Yahata, H., Niwa, K., Kitajima, A., Tezuka, Y., Watanabe, S. & Tanaka, K., 2022/04, In: Traditional & Kampo Medicine. 9, 1, p. 41-48 8 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Food odor perception promotes systemic lipid utilization

Tsuneki, H., Sugiyama, M., Ito, T., Sato, K., Matsuda, H., Onishi, K., Yubune, K., Matsuoka, Y., Nagai, S., Yamagishi, T., Maeda, T., Honda, K., Okekawa, A., Watanabe, S., Yaku, K., Okuzaki, D., Otsubo, R., Nomoto, M., Inokuchi, K. & Nakagawa, T. & 3 others, Wada, T., Yasui, T. & Sasaoka, T., 2022/11, In: Nature Metabolism. 4, 11, p. 1514-1531

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Food odor perception promotes systemic lipid utilization

Tsuneki, H., Sugiyama, M., Ito, T., Sato, K., Matsuda, H., Onishi, K., Yubune, K., Matsuoka, Y., Nagai, S., Yamagishi, T., Maeda, T., Honda, K., Okekawa, A., Watanabe, S., Yaku, K., Okuzaki, D., Otsubo, R., Nomoto, M., Inokuchi, K. & Nakagawa, T. & 3 others, Wada, T., Yasui, T. & Sasaoka, T., 2022/11, In: Nature Metabolism. 4, 11, p. 1514-1531 18 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

16 被引用数 (Scopus)

Hyodeoxycholic Acid (HDCA) Prevents Development of Dextran Sulfate Sodium (DSS)-Induced Colitis in Mice: Possible Role of Synergism between DSS and HDCA in Increasing Fecal Bile Acid Levels

Watanabe, S., Chen, Z., Fujita, K., Nishikawa, M., Ueda, H., Iguchi, Y., Une, M., Nishida, T. & Imura, J., 2022/10, In: Biological and Pharmaceutical Bulletin. 45, 10, p. 1503-1509 7 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

7 被引用数 (Scopus)

2021

Acyl-CoA thioesterase activity of peroxisomal ABC protein ABCD1 is required for the transport of very long-chain acyl-CoA into peroxisomes

Kawaguchi, K., Mukai, E., Watanabe, S., Yamashita, A., Morita, M., So, T. & Imanaka, T., 2021/12, In: Scientific Reports. 11, 1, 2192.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

15 被引用数 (Scopus)

Bone marrow transplantation into Abcd1-deficient mice: Distribution of donor derived-cells and biological characterization of the brain of the recipient mice

Morita, M., Kaizawa, T., Yoda, T., Oyama, T., Asakura, R., Matsumoto, S., Nagai, Y., Watanabe, Y., Watanabe, S., Kobayashi, H., Kawaguchi, K., Yamamoto, S., Shimozawa, N., So, T. & Imanaka, T., 2021/05, In: Journal of Inherited Metabolic Disease. 44, 3, p. 718-727 10 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

1 被引用数 (Scopus)

Generation of an immortalized astrocytic cell line from Abcd1-deficient H-2K^btsA58 mice to facilitate the study of the role of astrocytes in X-linked adrenoleukodystrophy

Morita, M., Toida, A., Horiuchi, Y., Watanabe, S., Sasahara, M., Kawaguchi, K., So, T. & Imanaka, T., 2021/02, In: Heliyon. 7, 2, e06228.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

5 被引用数 (Scopus)

Triiodothyronine Aggravates Global Cerebral Ischemia-Reperfusion Injury in Mice

Doshi, M., Watanabe, S., Natori, Y., Hosoyamada, M. & Hirashima-Akae, Y., 2021/12, In: Biological and Pharmaceutical Bulletin. 44, 12, p. 1824-1831 8 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

4 被引用数 (Scopus)

Triiodothyronine Aggravates Global Cerebral Ischemia–Reperfusion Injury in Mice

Watanabe, S., 2021, In: Biological and Pharmaceutical Bulletin. 10.1248/bpb.b21-00424

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Triiodothyronine Aggravates Global Cerebral Ischemia–Reperfusion Injury in Mice

Watanabe, S., 2021, In: Biological and Pharmaceutical Bulletin.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

α-Linolenic acid in Papilio machaon larvae regurgitant induces a defensive response in Apiaceae

Nishidono, Y., Niwa, K., Kitajima, A., Watanabe, S., Tezuka, Y., Arita, M., Takabayashi, J. & Tanaka, K., 2021/08, In: Phytochemistry. 188, 112796.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

4 被引用数 (Scopus)

2020

A New Monoterpenoid Glucoindole Alkaloid From Dipsacus asper

Li, F., Nishidono, Y., Tanaka, K., Watanabe, S. & Tezuka, Y., 2020, In: Natural Product Communications. 15, 4

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

6 被引用数 (Scopus)

Bofutsushosan improves gut barrier function with a bloom of Akkermansia muciniphila and improves glucose metabolism in mice with diet-induced obesity

Fujisaka, S., Usui, I., Nawaz, A., Igarashi, Y., Okabe, K., Furusawa, Y., Watanabe, S., Yamamoto, S., Sasahara, M., Watanabe, Y., Nagai, Y., Yagi, K., Nakagawa, T. & Tobe, K., 2020/12/01, In: Scientific Reports. 10, 1, 5544.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

64 被引用数 (Scopus)

Boiogito extract alters fecal bile acid profile in mice: Possible roles in changes in fecal and liver lipid levels

Chen, Z., Watanabe, S., Nishidono, Y. & Tanaka, K., 2020/12, In: Traditional & Kampo Medicine. 7, 3, p. 138-145 8 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

2 被引用数 (Scopus)

Sidechain Diversification of Grandifloracin Allows Identification of Analogues with Enhanced Anti-Austerity Activity against Human PANC-1 Pancreatic Cancer Cells

Alexander, B. E., Sun, S., Palframan, M. J., Kociok-Köhn, G., Dibwe, D. F., Watanabe, S., Caggiano, L., Awale, S. & Lewis, S. E., 2020/01/07, In: ChemMedChem. 15, 1, p. 125-135 11 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

11 被引用数 (Scopus)

胆汁酸による脂肪合成系の制御

Watanabe, S., 2020, In: Seikagaku. 92, 5, p. 680-687 8 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

2019

Boiogito prevents dietary lithocholic acid (LCA)-induced cholestatic liver injury through the suppression of intestinal LCA absorption

Watanabe, S., Chen, Z. & Fujita, K., 2019, In: Traditional & Kampo Medicine. 6, 2, p. 71-78 8 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

1 被引用数 (Scopus)

2018

Ameliorative effect of animal bile preparations on dextran sulfate sodium-induced colitis in mice

Watanabe, S., Fujita, K., Nishida, T. & Imura, J., 2018/10, In: Traditional & Kampo Medicine. 5, 2, p. 67-74 8 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

1 被引用数 (Scopus)

Characterization of human ATP-binding cassette protein subfamily D reconstituted into proteoliposomes

Okamoto, T., Kawaguchi, K., Watanabe, S., Agustina, R., Ikejima, T., Ikeda, K., Nakano, M., Morita, M. & Imanaka, T., 2018/02/19, In: Biochemical and Biophysical Research Communications. 496, 4, p. 1122-1127 6 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

24 被引用数 (Scopus)

Lysophosphatidic acid in medicinal herbs enhances prostaglandin E₂ and protects against indomethacin-induced gastric cell damage in vivo and in vitro

Afroz, S., Yagi, A., Fujikawa, K., Rahman, M. M., Morito, K., Fukuta, T., Watanabe, S., Kiyokage, E., Toida, K., Shimizu, T., Ishida, T., Kogure, K., Tokumura, A. & Tanaka, T., 2018/03, In: Prostaglandins and Other Lipid Mediators. 135, p. 36-44 9 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

15 被引用数 (Scopus)

2017

Ursodeoxycholic Acid Suppresses Lipogenesis in Mouse Liver: Possible Role of the Decrease in β-Muricholic Acid, a Farnesoid X Receptor Antagonist

Fujita, K., Iguchi, Y., Une, M. & Watanabe, S., 2017/04/01, In: Lipids. 52, 4, p. 335-344 10 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

23 被引用数 (Scopus)

2016

A novel method for determining peroxisomal fatty acid β-oxidation

Morita, M., Matsumoto, S., Okazaki, A., Tomita, K., Watanabe, S., Kawaguchi, K., Minato, D., Matsuya, Y., Shimozawa, N. & Imanaka, T., 2016/09/01, In: Journal of Inherited Metabolic Disease. 39, 5, p. 725-731 7 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

3 被引用数 (Scopus)

Changes in liver lipidomics associated with sodium cholate-induced liver injury and its prevention by boiogito, a Japanese herbal medicine, in mice

Watanabe, S., Fujita, K., Tsuneyama, K. & Nose, M., 2016/04, In: Traditional & Kampo Medicine. 3, 1, p. 9-19 11 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

5 被引用数 (Scopus)

2015

Brain microsomal fatty acid elongation is increased in abcd1-deficient mouse during active myelination phase

Morita, M., Kawamichi, M., Shimura, Y., Kawaguchi, K., Watanabe, S. & Imanaka, T., 2015/12/01, In: Metabolic Brain Disease. 30, 6, p. 1359-1367 9 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

6 被引用数 (Scopus)

Chemical profiling with HPLC-FTMS of exogenous and endogenous chemicals susceptible to the administration of chotosan in an animal model of type 2 diabetes-induced dementia

Niu, Y., Li, F., Inada, C., Tanaka, K., Watanabe, S., Fujiwara, H., Sasaki-Hamada, S., Oka, J. I. & Matsumoto, K., 2015/02/01, In: Journal of Pharmaceutical and Biomedical Analysis. 104, p. 21-30 10 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

17 被引用数 (Scopus)

2014

Dietary hyodeoxycholic acid exerts hypolipidemic effects by reducing farnesoid X receptor antagonist bile acids in mouse enterohepatic tissues

Watanabe, S. & Fujita, K., 2014/09/05, In: Lipids. 49, 10, p. 963-973 11 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

29 被引用数 (Scopus)

Role of transient receptor potential vanilloid 4 activation in indomethacin-induced intestinal damage

Yamawaki, H., Mihara, H., Suzuki, N., Nishizono, H., Uchida, K., Watanabe, S., Tominaga, M. & Sugiyama, T., 2014/07/01, In: American Journal of Physiology - Gastrointestinal and Liver Physiology. 307, 1, p. G33-G40

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

29 被引用数 (Scopus)

2013

Dipasperoside A, a novel pyridine alkaloid-coupled iridoid glucoside from the roots of Dipsacus asper

Li, F., Tanaka, K., Watanabe, S., Tezuka, Y. & Saiki, I., 2013/12, In: Chemical and Pharmaceutical Bulletin. 61, 12, p. 1318-1322 5 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

20 被引用数 (Scopus)

Eicosapentaenoic acid attenuates hepatic accumulation of cholesterol esters but aggravates liver injury and inflammation in mice fed a cholate-supplemented high-fat diet

Watanabe, S. & Tsuneyama, K., 2013/06, In: Journal of Toxicological Sciences. 38, 3, p. 379-390 12 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

8 被引用数 (Scopus)

LC-MS and multivariate analysis

Tanaka, K., Li, F., Tezuka, Y., Watanabe, S., Kawahara, N. & Kida, H., 2013, In: Natural Product Communications. 8, 1, p. 75-78 4 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

9 被引用数 (Scopus)

Pig bile reduces hepatic triglyceride content in mice

Watanabe, S. & Fujita, K., 2013, In: Journal of Traditional Medicines. 30, 4, p. 190-197 8 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

2 被引用数 (Scopus)

2012

A new methodology for simultaneous quantification of total-Aβ, Aβx-38, Aβx-40, and Aβx-42 by column-switching LC/MS/MS

Watanabe, K. I., Ishikawa, C., Kuwahara, H., Sato, K., Komuro, S., Nakagawa, T., Nomura, N., Watanabe, S. & Yabuki, M., 2012/02, In: Analytical and Bioanalytical Chemistry. 402, 6, p. 2033-2042 10 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

16 被引用数 (Scopus)

Cattle bile but not bear bile or pig bile induces lipid profile changes and fatty liver injury in mice: Mediation by cholic acid

Watanabe, S. & Tsuneyama, K., 2012/02, In: Journal of Toxicological Sciences. 37, 1, p. 105-121 17 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

19 被引用数 (Scopus)

2011

Cattle bile aggravates diclofenac sodium-induced small intestinal injury in mice

Watanabe, S. & Ishikawa, H., 2011, In: Evidence-based Complementary and Alternative Medicine. 2011, 315858.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

1 被引用数 (Scopus)

2010

A triglyceride-lowering effect of cattle bile is associated with elevation of cholesterol levels and liver injury in mice

Watanabe, S. & Tsuneyama, K., 2010, In: Journal of Traditional Medicines. 27, 4, p. 179-185 7 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

3 被引用数 (Scopus)

2009

Roles of bile acid conjugates and phospholipids in in vitro activation of pancreatic lipase by bear bile and cattle bile

Watanabe, S., Kamei, T., Tanaka, K., Kawasuji, K., Yoshioka, T. & Ohno, M., 2009/09/07, In: Journal of Ethnopharmacology. 125, 2, p. 203-206 4 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

15 被引用数 (Scopus)

2008

Chiisanoside is not absorbed but inhibits oil absorption in the small intestine of rodents

Yoshizumi, K., Murota, K., Watanabe, S., Tomi, H., Tsuji, T. & Terao, J., 2008, In: Bioscience, biotechnology, and biochemistry. 72, 4, p. 1126-1129 4 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

21 被引用数 (Scopus)

Differential modulation of lipopolysaccharide- and zymosan-induced hypophagia by dexamethasone treatment

Saito, M. & Watanabe, S., 2008/09, In: Pharmacology Biochemistry and Behavior. 90, 3, p. 428-433 6 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

8 被引用数 (Scopus)

Scutellariae Radix aggravates diclofenac sodium-induced enteropathy in mice

Dobashi, K., Ohkoshi, E., Fujii, Y., Nagai, M. & Watanabe, S., 2008, In: Journal of Traditional Medicines. 25, 3, p. 81-86 6 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

1 被引用数 (Scopus)

Scutellariae Radix augments ulceration but attenuates proinflammatory cytokine and chemokine gene induction in the small intestine during indomethacin-induced enteropathy in mice

Watanabe, S., Yamada, Y., Dobashi, K. & Saito, M., 2008, In: Journal of Traditional Medicines. 25, 2, p. 55-59 5 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

1 被引用数 (Scopus)

渡辺 志朗

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渡辺志朗