年別の研究成果
年別の研究成果
- 21 件
検索結果
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2025
Role of transforming growth factor-β1 in regulating adipocyte progenitors
Phuong, N. Q., Bilal, M., Nawaz, A., Anh, L. D., Memoona, Aslam, M. R., Khalid, S., Kado, T., Watanabe, Y., Nishimura, A., Igarashi, Y., Okabe, K., Hirabayashi, K., Yamamoto, S., Nakagawa, T., Mori, H., Usui, I., Fujisaka, S., Hayashi, R. & Tobe, K., 2025/12, In: Scientific Reports. 15, 1, 941.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access -
2022
Depletion of CD206+ M2-like macrophages induces fibro-adipogenic progenitors activation and muscle regeneration
Nawaz, A., Bilal, M., Fujisaka, S., Kado, T., Aslam, M. R., Ahmed, S., Okabe, K., Igarashi, Y., Watanabe, Y., Kuwano, T., Tsuneyama, K., Nishimura, A., Nishida, Y., Yamamoto, S., Sasahara, M., Imura, J., Mori, H., Matzuk, M. M., Kudo, F. & Manabe, I. & 4 others, , 2022/12, In: Nature Communications. 13, 1, 7058.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access33 被引用数 (Scopus) -
Oral Administration of Nicotinamide Mononucleotide Is Safe and Efficiently Increases Blood Nicotinamide Adenine Dinucleotide Levels in Healthy Subjects
Okabe, K., Yaku, K., Uchida, Y., Fukamizu, Y., Sato, T., Sakurai, T., Tobe, K. & Nakagawa, T., 2022/04/11, In: Frontiers in Nutrition. 9研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
51 被引用数 (Scopus) -
2021
Astaxanthin, a marine carotenoid, maintains the tolerance and integrity of adipose tissue and contributes to its healthy functions
Nawaz, A., Nishida, Y., Takikawa, A., Fujisaka, S., Kado, T., Aminuddin, A., Bilal, M., Jeelani, I., Aslam, M. R., Nishimura, A., Kuwano, T., Watanabe, Y., Igarashi, Y., Okabe, K., Ahmed, S., Manzoor, A., Usui, I., Yagi, K., Nakagawa, T. & Tobe, K., 2021/12, In: Nutrients. 13, 12, 4374.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access10 被引用数 (Scopus) -
Implications of NAD metabolism in pathophysiology and therapeutics for neurodegenerative diseases
Hikosaka, K., Yaku, K., Okabe, K. & Nakagawa, T., 2021, In: Nutritional Neuroscience. 24, 5, p. 371-383 13 p.研究成果: ジャーナルへの寄稿 › 総説 › 査読
43 被引用数 (Scopus) -
2020
Bofutsushosan improves gut barrier function with a bloom of Akkermansia muciniphila and improves glucose metabolism in mice with diet-induced obesity
Fujisaka, S., Usui, I., Nawaz, A., Igarashi, Y., Okabe, K., Furusawa, Y., Watanabe, S., Yamamoto, S., Sasahara, M., Watanabe, Y., Nagai, Y., Yagi, K., Nakagawa, T. & Tobe, K., 2020/12/01, In: Scientific Reports. 10, 1, 5544.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access64 被引用数 (Scopus) -
NAD+ Metabolism Regulates Preadipocyte Differentiation by Enhancing α-Ketoglutarate-Mediated Histone H3K9 Demethylation at the PPARγ Promoter
Okabe, K., Nawaz, A., Nishida, Y., Yaku, K., Usui, I., Tobe, K. & Nakagawa, T., 2020/11/24, In: Frontiers in Cell and Developmental Biology. 8, 586179.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access26 被引用数 (Scopus) -
2019
Implications of altered NAD metabolism in metabolic disorders
Okabe, K., Yaku, K., Tobe, K. & Nakagawa, T., 2019/05/11, In: Journal of Biomedical Science. 26, 1, 34.研究成果: ジャーナルへの寄稿 › 総説 › 査読
Open Access166 被引用数 (Scopus) -
Macrophage-specific hypoxia-inducible factor-1α deletion suppresses the development of liver tumors in high-fat diet-fed obese and diabetic mice
Takikawa, A., Usui, I., Fujisaka, S., Tsuneyama, K., Okabe, K., Nakagawa, T., Nawaz, A., Kado, T., Jojima, T., Aso, Y., Hayakawa, Y., Yagi, K. & Tobe, K., 2019/11/01, In: Journal of Diabetes Investigation. 10, 6, p. 1411-1418 8 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access5 被引用数 (Scopus) -
Metabolism and biochemical properties of nicotinamide adenine dinucleotide (NAD) analogs, nicotinamide guanine dinucleotide (NGD) and nicotinamide hypoxanthine dinucleotide (NHD)
Yaku, K., Okabe, K., Gulshan, M., Takatsu, K., Okamoto, H. & Nakagawa, T., 2019/12/01, In: Scientific Reports. 9, 1, 13102.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access23 被引用数 (Scopus) -
2018
Deletion of PHGDH in adipocytes improves glucose intolerance in diet-induced obese mice
Okabe, K., Usui, I., Yaku, K., Hirabayashi, Y., Tobe, K. & Nakagawa, T., 2018/09/26, In: Biochemical and Biophysical Research Communications. 504, 1, p. 309-314 6 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
11 被引用数 (Scopus) -
Erratum to: Sirt1 activator induces proangiogenic genes in preadipocytes to rescue insulin resistance in diet-induced obese mice (Scientific Reports, (2018), 8, 1, (11370), 10.1038/s41598-018-29773-0)
Nawaz, A., Mehmood, A., Kanatani, Y., Kado, T., Igarashi, Y., Takikawa, A., Yamamoto, S., Okabe, K., Nakagawa, T., Yagi, K., Fujisaka, S. & Tobe, K., 2018/12/01, In: Scientific Reports. 8, 1, 14597.研究成果: ジャーナルへの寄稿 › コメント/討論
Open Access1 被引用数 (Scopus) -
NAD metabolism: Implications in aging and longevity
Yaku, K., Okabe, K. & Nakagawa, T., 2018/11, In: Ageing Research Reviews. 47, p. 1-17 17 p.研究成果: ジャーナルへの寄稿 › 総説 › 査読
206 被引用数 (Scopus) -
NAD metabolism in cancer therapeutics
Yaku, K., Okabe, K., Hikosaka, K. & Nakagawa, T., 2018, In: Frontiers in Oncology. 8, DEC, 622.研究成果: ジャーナルへの寄稿 › 総説 › 査読
Open Access165 被引用数 (Scopus) -
Overexpression of Nmnat3 efficiently increases NAD and NGD levels and ameliorates age-associated insulin resistance
Gulshan, M., Yaku, K., Okabe, K., Mahmood, A., Sasaki, T., Yamamoto, M., Hikosaka, K., Usui, I., Kitamura, T., Tobe, K. & Nakagawa, T., 2018/08, In: Aging Cell. 17, 4, e12798.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access39 被引用数 (Scopus) -
Simultaneous measurement of NAD metabolome in aged mice tissue using liquid chromatography tandem-mass spectrometry
Yaku, K., Okabe, K. & Nakagawa, T., 2018/06, In: Biomedical Chromatography. 32, 6, e4205.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
39 被引用数 (Scopus) -
Sirt1 activator induces proangiogenic genes in preadipocytes to rescue insulin resistance in diet-induced obese mice
Nawaz, A., Mehmood, A., Kanatani, Y., Kado, T., Igarashi, Y., Takikawa, A., Yamamoto, S., Okabe, K., Nakagawa, T., Yagi, K., Fujisaka, S. & Tobe, K., 2018/12/01, In: Scientific Reports. 8, 1, 11370.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access18 被引用数 (Scopus) -
2017
A case of a young pregnant woman with type 2 diabetes in which the progression of proliferative retinopathy and macular edema were observed until induced abortion
Honoki, H., Usui, I., Ueno, A., Kitano, K., Nakajima, A., Watanabe, Y., Okabe, K., Kado, T., Takikawa, A., Fujisaka, S., Koshimizu, Y., Kamura, Y., Fukuda, K., Ishiki, M., Iwata, M., Yanagisawa, S. & Tobe, K., 2017, In: Journal of the Japan Diabetes Society. 60, 12, p. 820-825 6 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
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2016
HIF-1α in myeloid cells promotes adipose tissue remodeling toward insulin resistance
Takikawa, A., Mahmood, A., Nawaz, A., Kado, T., Okabe, K., Yamamoto, S., Aminuddin, A., Senda, S., Tsuneyama, K., Ikutani, M., Watanabe, Y., Igarashi, Y., Nagai, Y., Takatsu, K., Koizumi, K., Imura, J., Goda, N., Sasahara, M., Matsumoto, M. & Saeki, K. & 4 others, , 2016/12/01, In: Diabetes. 65, 12, p. 3649-3659 11 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
93 被引用数 (Scopus) -
2014
Secretory units of islets in transplantation index is a useful predictor of insulin requirement in Japanese type 2 diabetic patients
Iwata, M., Matsushita, Y., Fukuda, K., Wakura, T., Okabe, K., Koshimizu, Y., Fukushima, Y., Kobashi, C., Yamazaki, Y., Honoki, H., Suzuki, H., Kigawa, M. & Tobe, K., 2014, In: Journal of Diabetes Investigation. 5, 5, p. 570-580 11 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access27 被引用数 (Scopus) -
2012
[Goal of treatment for diabetic patients].
Tobe, K. & Okabe, K., 2012/05, In: Nihon rinsho. Japanese journal of clinical medicine. 70 Suppl 3, p. 570-578 9 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読