年別の研究成果
年別の研究成果
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2024
Negative regulation of thyroid adenoma-associated protein (THADA) in the cardiac glycoside-induced anti-cancer effect
Katoh, M., Fujii, T., Tabuchi, Y., Shimizu, T. & Sakai, H., 2024/04/01, In: Journal of Physiological Sciences. 74, 1, p. 23 1 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access1 被引用数 (Scopus) -
2023
Activation of mouse Otop3 proton channels by Zn2+
Fujii, T., Shimizu, T., Kaji, Y., Katoh, M. & Sakai, H., 2023/05/28, In: Biochemical and Biophysical Research Communications. 658, p. 55-61 7 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access3 被引用数 (Scopus) -
Parkinson’s disease-associated ATP13A2/PARK9 functions as a lysosomal H+,K+-ATPase
Fujii, T., Nagamori, S., Wiriyasermkul, P., Zheng, S., Yago, A., Shimizu, T., Tabuchi, Y., Okumura, T., Fujii, T., Takeshima, H. & Sakai, H., 2023/12, In: Nature Communications. 14, 1, 2174.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access15 被引用数 (Scopus) -
Polycystic kidney disease 2-like 1 channel contributes to the bitter aftertaste perception of quinine
Shimizu, T., Fujii, T., Hanita, K., Shinozaki, R., Takamura, Y., Suzuki, Y., Kageyama, T., Kato, M., Nishijo, H., Tominaga, M. & Sakai, H., 2023/12, In: Scientific Reports. 13, 1, 4271.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access -
2022
Cardiac glycosides stimulate endocytosis of GLUT1 via intracellular Na+,K+-ATPase α3-isoform in human cancer cells
Fujii, T., Katoh, M., Ootsubo, M., Nguyen, O. T. T., Iguchi, M., Shimizu, T., Tabuchi, Y., Shimizu, Y., Takeshima, H. & Sakai, H., 2022/07, In: Journal of Cellular Physiology. 237, 7, p. 2980-2991 12 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
10 被引用数 (Scopus) -
Regulation of TRPV1 channel activities by intracellular ATP in the absence of capsaicin
Shimizu, T., Yanase, N., Fujii, T., Sakakibara, H. & Sakai, H., 2022/02/01, In: Biochimica et Biophysica Acta - Biomembranes. 1864, 1, 183782.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access4 被引用数 (Scopus) -
The Molded Tablet, a disintegrant-free orally disintegrating tablet, resists thickening solution-reduced drug dissolution
Onuki, Y., Sugiura, D., Kumada, S., Kobayashi, R., Nakamura, T., Kogawa, T., Sakai, H. & Okada, K., 2022/03, In: Journal of Drug Delivery Science and Technology. 69, 103179.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access6 被引用数 (Scopus) -
2021
Inhibition of gastric H+,K+-ATPase by new dihydropyrazole derivative KYY-008
Fujii, T., Sugimoto, K., Noda, T., Shimizu, T., Matsuya, Y. & Sakai, H., 2021/08/27, In: Biochemical and Biophysical Research Communications. 567, p. 177-182 6 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access2 被引用数 (Scopus) -
Survival of detached cancer cells is regulated by movement of intracellular Na+,K+-ATPase
Fujii, T., Shimizu, T., Katoh, M., Nagamori, S., Koizumi, K., Fukuoka, J., Tabuchi, Y., Sawaguchi, A., Okumura, T., Shibuya, K., Fujii, T., Takeshima, H. & Sakai, H., 2021/05/21, In: iScience. 24, 5, 102412.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access11 被引用数 (Scopus) -
Total synthesis of decahydroquinoline poison frog alkaloids ent-cis-195a and cis-211a
Okada, T., Wu, N., Takashima, K., Ishimura, J., Morita, H., Ito, T., Kodama, T., Yamasaki, Y., Akanuma, S. I., Kubo, Y., Hosoya, K. I., Tsuneki, H., Wada, T., Sasaoka, T., Shimizu, T., Sakai, H., Dwoskin, L. P., Hussaini, S. R., Saporito, R. A. & Toyooka, N., 2021/12/01, In: Molecules. 26, 24, 7529.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access5 被引用数 (Scopus) -
2020
Impaired actin filaments decrease cisplatin sensitivity via dysfunction of volume-sensitive Cl− channels in human epidermoid carcinoma cells
Shimizu, T., Fujii, T., Ohtake, H., Tomii, T., Takahashi, R., Kawashima, K. & Sakai, H., 2020/12/01, In: Journal of Cellular Physiology. 235, 12, p. 9589-9600 12 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
5 被引用数 (Scopus) -
Pathophysiological properties of CLIC3 chloride channel in human gastric cancer cells
Kawai, S., Fujii, T., Shimizu, T., Sukegawa, K., Hashimoto, I., Okumura, T., Nagata, T., Sakai, H. & Fujii, T., 2020/02/17, In: Journal of Physiological Sciences. 70, 1, 15.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access8 被引用数 (Scopus) -
地方大学医療系キャンパスでのオンライン授業導入報告
Mihara, H., Kishi, H., Adachi, Y., Shimizu, T., Sakai, H., Oku, M. & Fujii, A., 2020, In: 医学教育. 51, 3, p. 255-257 3 p.研究成果: ジャーナルへの寄稿 › 学術論文
Open Access -
2019
Cancer cell-specific functional relation between Na+,K+-ATPase and volume-regulated anion channel
Fujii, T., Shimizu, T., Takeshima, H. & Sakai, H., 2019, In: Folia Pharmacologica Japonica. 154, 3, p. 103-107 5 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access1 被引用数 (Scopus) -
High-resolution label-free 3D mapping of extracellular pH of single living cells
Zhang, Y., Takahashi, Y., Hong, S. P., Liu, F., Bednarska, J., Goff, P. S., Novak, P., Shevchuk, A., Gopal, S., Barozzi, I., Magnani, L., Sakai, H., Suguru, Y., Fujii, T., Erofeev, A., Gorelkin, P., Majouga, A., Weiss, D. J., Edwards, C. & Ivanov, A. P. & 4 others, , 2019/12/01, In: Nature Communications. 10, 1, 5610.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access76 被引用数 (Scopus) -
Negative regulation of gastric proton pump by desialylation suggested by fluorescent imaging with the sialic acid-specific nanoprobe
Fujii, T., Shimizu, T., Kushiro, K., Takeshima, H., Takai, M. & Sakai, H., 2019, In: Folia Pharmacologica Japonica. 153, 6, p. 261-266 6 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access -
Non-morphogenic effect of Sonic Hedgehog on gastric H+,K+-ATPase activity
Fujii, T., Phutthatiraphap, S., Shimizu, T., Takeshima, H. & Sakai, H., 2019/10/20, In: Biochemical and Biophysical Research Communications. 518, 3, p. 605-609 5 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
2 被引用数 (Scopus) -
2018
Crosstalk between Na+,K+-ATPase and a volume-regulated anion channel in membrane microdomains of human cancer cells
Fujii, T., Shimizu, T., Yamamoto, S., Funayama, K., Fujita, K., Tabuchi, Y., Ikari, A., Takeshima, H. & Sakai, H., 2018/11, In: Biochimica et Biophysica Acta - Molecular Basis of Disease. 1864, 11, p. 3792-3804 13 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access38 被引用数 (Scopus) -
Elevation of sensitivity to anticancer agents of human lung adenocarcinoma A549 cells by knockdown of claudin-2 expression in monolayer and spheroid culture models
Maruhashi, R., Akizuki, R., Sato, T., Matsunaga, T., Endo, S., Yamaguchi, M., Yamazaki, Y., Sakai, H. & Ikari, A., 2018/03, In: BBA - Molecular Cell Research. 1865, 3, p. 470-479 10 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access25 被引用数 (Scopus) -
Inhibition of gastric H+,K+-ATPase activity in vitro by dissolution media of original brand-name and generic tablets of lansoprazole, a proton pump inhibitor
Phutthatiraphap, S., Hayashi, Y., Fujii, T., Kosugi, A., Okada, K., Kadozaki, T., Ishise, T., Sakai, H. & Onuki, Y., 2018, In: Chemical and Pharmaceutical Bulletin. 66, 9, p. 896-900 5 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access1 被引用数 (Scopus) -
The natural flavonoid myricetin inhibits gastric H+, K+-ATPase
Miyazaki, Y., Ichimura, A., Sato, S., Fujii, T., Oishi, S., Sakai, H. & Takeshima, H., 2018/02/05, In: European Journal of Pharmacology. 820, p. 217-221 5 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
29 被引用数 (Scopus) -
2017
The asparagine 533 residue in the outer pore loop region of the mouse PKD2L1 channel is essential for its voltage-dependent inactivation
Shimizu, T., Higuchi, T., Toba, T., Ohno, C., Fujii, T., Nilius, B. & Sakai, H., 2017/09, In: FEBS Open Bio. 7, 9, p. 1392-1401 10 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access4 被引用数 (Scopus) -
2016
Hypotonic stress-induced down-regulation of claudin-1 and -2 mediated by dephosphorylation and clathrin-dependent endocytosis in renal tubular epithelial cells
Fujii, N., Matsuo, Y., Matsunaga, T., Endo, S., Sakai, H., Yamaguchi, M., Yamazaki, Y., Sugatani, J. & Ikari, A., 2016/11/18, In: Journal of Biological Chemistry. 291, 47, p. 24787-24799 13 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access30 被引用数 (Scopus) -
Positive regulation of the enzymatic activity of gastric H+,K+-ATPase by sialylation of its β-subunit
Fujii, T., Watanabe, M., Shimizu, T., Takeshima, H., Kushiro, K., Takai, M. & Sakai, H., 2016/06/01, In: Biochimica et Biophysica Acta - Biomembranes. 1858, 6, p. 1228-1235 8 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access6 被引用数 (Scopus) -
2015
Clathrin-dependent endocytosis of claudin-2 by DFYSP peptide causes lysosomal damage in lung adenocarcinoma A549 cells
Ikari, A., Taga, S., Watanabe, R., Sato, T., Shimobaba, S., Sonoki, H., Endo, S., Matsunaga, T., Sakai, H., Yamaguchi, M., Yamazaki, Y. & Sugatani, J., 2015/07/20, In: Biochimica et Biophysica Acta - Biomembranes. 1848, 10, p. 2326-2336 11 p., 81947.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access13 被引用数 (Scopus) -
Inhibition of gastric H+,K+-ATPase by 4-(2-butyl-6,7-dichloro-2-cyclopentylindan-1-on-5-yl)oxybutyric acid (DCPIB), an inhibitor of volume-regulated anion channel
Fujii, T., Takahashi, Y., Takeshima, H., Saitoh, C., Shimizu, T., Takeguchi, N. & Sakai, H., 2015/08/13, In: European Journal of Pharmacology. 765, p. 34-41 8 p., EJP41856.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
26 被引用数 (Scopus) -
Volume-sensitive outwardly rectifying Cl− channels contribute to butyrate-triggered apoptosis of murine colonic epithelial MCE301 cells
Shimizu, T., Ohtake, H., Fujii, T., Tabuchi, Y. & Sakai, H., 2015/03/19, In: Journal of Physiological Sciences. 65, 2, p. 151-157 7 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access6 被引用数 (Scopus) -
2014
Functional coupling of chloride-proton exchanger ClC-5 to gastric H+,K+-ATPase
Takahashi, Y., Fujii, T., Fujita, K., Shimizu, T., Higuchi, T., Tabuchi, Y., Sakamoto, H., Naito, I., Manabe, K., Uchida, S., Sasaki, S., Ikari, A., Tsukada, K. & Sakai, H., 2014/01/15, In: Biology Open. 3, 1, p. 12-21 10 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access14 被引用数 (Scopus) -
Gating modulation by heat of the polycystin transient receptor potential channel PKD2L1 (TRPP3)
Higuchi, T., Shimizu, T., Fujii, T., Nilius, B. & Sakai, H., 2014/10, In: Pflugers Archiv European Journal of Physiology. 466, 10, p. 1933-1940 8 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
13 被引用数 (Scopus) -
Tight junctional localization of Claudin-16 is regulated by syntaxin 8 in renal tubular epithelial cells
Ikari, A., Tonegawa, C., Sanada, A., Kimura, T., Sakai, H., Hayashi, H., Hasegawa, H., Yamaguchi, M., Yamazaki, Y., Endo, S., Matsunaga, T. & Sugatani, J., 2014, In: Journal of Biological Chemistry. 289, 19, p. 13112-13123 12 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access19 被引用数 (Scopus) -
Up-regulation of Kv7.1 channels in thromboxane A2-induced colonic cancer cell proliferation
Shimizu, T., Fujii, T., Takahashi, Y., Takahashi, Y., Suzuki, T., Ukai, M., Tauchi, K., Horikawa, N., Tsukada, K. & Sakai, H., 2014/03, In: Pflugers Archiv European Journal of Physiology. 466, 3, p. 541-548 8 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
18 被引用数 (Scopus) -
2013
Hyperosmolarity-induced up-regulation of claudin-4 mediated by NADPH oxidase-dependent H2O2 production and Sp1/c-Jun cooperation
Ikari, A., Atomi, K., Yamazaki, Y., Sakai, H., Hayashi, H., Yamaguchi, M. & Sugatani, J., 2013/12, In: BBA - Molecular Cell Research. 1833, 12, p. 2617-2627 11 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access22 被引用数 (Scopus) -
Modulation of H+,K+-ATPase activity by the molecular chaperone ERp57 highly expressed in gastric parietal cells
Fujii, T., Awaka, S. Y., Takahashi, Y., Fujita, K., Tsuji, H., Shimizu, T., Gomi, T., Tsukada, K. & Sakai, H., 2013/12/11, In: FEBS Letters. 587, 24, p. 3898-3905 8 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access11 被引用数 (Scopus) -
TMEM16F is a component of a Ca2+-activated Cl- channel but not a volume-sensitive outwardly rectifying Cl- channel
Shimizu, T., Iehara, T., Sato, K., Fujii, T., Sakai, H. & Okada, Y., 2013/04/15, In: American Journal of Physiology - Cell Physiology. 304, 8, p. C748-C759研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
107 被引用数 (Scopus) -
2012
Inhibition of ecto-ATPase activity by curcumin in hepatocellular carcinoma HepG2 cells
Fujii, T., Minagawa, T., Shimizu, T., Takeguchi, N. & Sakai, H., 2012/01, In: Journal of Physiological Sciences. 62, 1, p. 53-58 6 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
11 被引用数 (Scopus) -
Involvements of the ABC protein ABCF2 and α-actinin-4 in regulation of cell volume and anion channels in human epithelial cells
Ando-Akatsuka, Y., Shimizu, T., Numata, T. & Okada, Y., 2012/10, In: Journal of Cellular Physiology. 227, 10, p. 3498-3510 13 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
23 被引用数 (Scopus) -
Role of cholesterol in functional association between K +-Cl - cotransporter-3a and Na +,K +-ATPase
Fujita, K., Fujii, T., Shimizu, T., Takeguchi, N. & Sakai, H., 2012/07/20, In: Biochemical and Biophysical Research Communications. 424, 1, p. 136-140 5 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
1 被引用数 (Scopus) -
Synthesis and biological activities of the 3,5-disubstituted indolizidine poison frog alkaloid 239Q and its congeners
Wang, X., Tsuneki, H., Urata, N., Tezuka, Y., Wada, T., Sasaoka, T., Sakai, H., Saporito, R. A. & Toyooka, N., 2012/12, In: European Journal of Organic Chemistry. 36, p. 7082-7092 11 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
15 被引用数 (Scopus) -
The apoptotic volume decrease is an upstream event of MAP kinase activation during staurosporine-induced apoptosis in HeLa cells
Hasegawa, Y., Shimizu, T., Takahashi, N. & Okada, Y., 2012/07, In: International Journal of Molecular Sciences. 13, 7, p. 9363-9379 17 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access26 被引用数 (Scopus) -
TRIM50 protein regulates vesicular trafficking for acid secretion in gastric parietal cells
Nishi, M., Aoyama, F., Kisa, F., Zhu, H., Sun, M., Lin, P., Ohta, H., Van, B., Yamamoto, S., Kakizawa, S., Sakai, H., Ma, J., Sawaguchi, A. & Takeshima, H., 2012/09/28, In: Journal of Biological Chemistry. 287, 40, p. 33523-33532 10 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access11 被引用数 (Scopus) -
2011
Bimodal effect of alkalization on the polycystin transient receptor potential channel, PKD2L1
Shimizu, T., Higuchi, T., Fujii, T., Nilius, B. & Sakai, H., 2011/05, In: Pflugers Archiv European Journal of Physiology. 461, 5, p. 507-513 7 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
22 被引用数 (Scopus) -
Molecular mechanisms of H+ and Cl- secretion in gastric parietal cells
Fujii, T., Morii, M., Takeguchi, N. & Sakai, H., 2011, In: Folia Pharmacologica Japonica. 138, 2, p. 51-55 5 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access -
2010
Increase in ouabain-sensitive K+-ATPase activity in hepatocellular carcinoma by overexpression of Na+,K+-ATPase α3-isoform
Shibuya, K., Fukuoka, J., Fujii, T., Shimoda, E., Shimizu, T., Sakai, H. & Tsukada, K., 2010/07, In: European Journal of Pharmacology. 638, 1-3, p. 42-46 5 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
22 被引用数 (Scopus) -
The NH2-terminus of K+-Cl- cotransporter 3a is essential for up-regulation of Na+,K+-ATPase activity
Fujii, T., Fujita, K., Shimizu, T., Takeguchi, N. & Sakai, H., 2010/09, In: Biochemical and Biophysical Research Communications. 399, 4, p. 683-687 5 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
10 被引用数 (Scopus) -
2009
Bradykinin-induced astrocyte-neuron signalling: Glutamate release is mediated by ROS-activated volume-sensitive outwardly rectifying anion channels
Liu, H. T., Akita, T., Shimizu, T., Sabirov, R. Z. & Okada, Y., 2009, In: Journal of Physiology. 587, 10, p. 2197-2209 13 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access85 被引用数 (Scopus) -
Functional association between K+-Cl- cotransporter-4 and H+,K+-ATPase in the apical canalicular membrane of gastric parietal cells
Fujii, T., Takahashi, Y., Ikari, A., Morii, M., Tabuchi, Y., Tsukada, K., Takeguchi, N. & Sakai, H., 2009/01/02, In: Journal of Biological Chemistry. 284, 1, p. 619-629 11 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access45 被引用数 (Scopus) -
Involvement of aquaporin-5 in differentiation of human gastric cancer cells
Watanabe, T., Fujii, T., Oya, T., Horikawa, N., Tabuchi, Y., Takahashi, Y., Morii, M., Takeguchi, N., Tsukada, K. & Sakai, H., 2009/03, In: Journal of Physiological Sciences. 59, 2, p. 113-122 10 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access58 被引用数 (Scopus) -
Regulation of the murine TRPP3 channel by voltage, pH, and changes in cell volume
Shimizu, T., Janssens, A., Voets, T. & Nilius, B., 2009/02, In: Pflugers Archiv European Journal of Physiology. 457, 4, p. 795-807 13 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access68 被引用数 (Scopus) -
Synthesis, determination of the absolute stereochemistry, and evaluations at the nicotinic acetylcholine receptors of a hydroxyindolizidine alkaloid from the ant Myrmicaria melanogaster
Zhou, D., Toyooka, N., Nemoto, H., Yamaguchi, K., Tsuneki, H., Wada, T., Sasaoka, T., Sakai, H., Tezuka, Y., Kadota, S., Jones, T. H., Garraffo, H. M., Spande, T. F. & Daly, J. W., 2009, In: Heterocycles. 79, C, p. 565-571 7 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access5 被引用数 (Scopus) -
TRPM4 regulates migration of mast cells in mice
Shimizu, T., Owsianik, G., Freichel, M., Flockerzi, V., Nilius, B. & Vennekens, R., 2009/03, In: Cell Calcium. 45, 3, p. 226-232 7 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access84 被引用数 (Scopus)