臨床分子病態検査学講座

2024

Female sample screening using colorimetric reverse transcription loop-mediated isothermal amplification (RT-LAMP) targeting non-coding RNA XIST

Kubo, S., Amai, K., Tanaka, J. & Niimi, H., 2024/08, In: Forensic Science International. 361, 112081.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

High interleukin-6 levels induced by COVID-19 pneumonia correlate with increased circulating follicular helper T cell frequency and strong neutralization antibody response in the acute phase of Omicron breakthrough infection

Kawasuji, H., Morinaga, Y., Nagaoka, K., Tani, H., Yoshida, Y., Yamada, H., Takegoshi, Y., Kaneda, M., Murai, Y., Kimoto, K., Niimi, H. & Yamamoto, Y., 2024, In: Frontiers in Immunology. 15, 1377014.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

1 被引用数 (Scopus)

Increased Cerebrospinal Fluid Adenosine 5′-Triphosphate Levels in Patients with Guillain-Barré Syndrome and Chronic Inflammatory Demyelinating Polyneuropathy

Nukui, T., Niimi, H., Hayashi, T., Dogu, N., Yamamoto, M., Shibuya, R., Matsuda, N., Tanaka, R., Hirosawa, H., Furuta, R., Mitsui, T., Maesaka, H., Takasawa, S., Kitajima, I. & Nakatsuji, Y., 2024, In: Neurology Research International. 2024, 7229216.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

Low pre-infection levels of neutralizing antibody in breakthrough infections after bivalent BA.4–5 vaccine and practical application of dried blood spots

Kawasuji, H., Morinaga, Y., Tani, H., Yamada, H., Yoshida, Y., Ezaki, M., Koshiyama, Y., Takegoshi, Y., Kaneda, M., Murai, Y., Kimoto, K., Nagaoka, K., Niimi, H. & Yamamoto, Y., 2024/09/17, In: Vaccine. 42, 22, 126029.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

Melting temperature mapping method in children: Rapid identification of pathogenic microbes

Ishikawa, T., Uejima, Y., Okai, M., Shiga, K., Shoji, K., Miyairi, I., Kato, M., Morooka, S., Kubota, M., Tagaya, T., Tsuji, S., Aoki, S., Ide, K., Niimi, H., Uchiyama, T., Onodera, M. & Kawai, T., 2024/06, In: Journal of Infection and Chemotherapy. 30, 6, p. 475-480 6 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Melting temperature mapping method using imperfect-match linear long probes

Ootsuki, S., Niimi, H., Ueno, T., Mori, M., Tabata, H., Minami, H. & Kitajima, I., 2024/12, In: Scientific Reports. 14, 1, 11055.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

Novel rapid method for identifying and quantifying pathogenic bacteria within four hours of blood collection

Miyakoshi, A., Niimi, H., Ueno, T., Wakasugi, M., Higashi, Y., Miyajima, Y., Mori, M., Tabata, H., Minami, H., Takaoka, A., Hayashi, A., Yamamoto, Y. & Kitajima, I., 2024/12, In: Scientific Reports. 14, 1, 1199.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

1 被引用数 (Scopus)

The fatal case of “Pigmentibacter” bacteremia following aspiration pneumonia in elderly patient

Azuma, S., Kawasuji, H., Nakai, R., Yamada, H., Yoshida, Y., Kawahara, H., Suzuki, M., Mori, S., Hirata, M., Sugie, K., Niimi, H., Morinaga, Y. & Yamamoto, Y., 2024/08, In: Journal of Infection and Chemotherapy. 30, 8, p. 806-811 6 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Time-dependent changes in cell population data obtained using Sysmex XN-series hematology analyzer in bacterial infections: Cell population data to predict bacteremia

Kaneda, M., Nagaoka, K., Yoshida, R., Iwasaki, Y., Niimi, H. & Yamamoto, Y., 2024, (受理済み/印刷中) In: Journal of Infection and Chemotherapy.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

1 被引用数 (Scopus)

2023

Disseminated nocardiosis complicated by multiple abscesses of the brain and lower limbs diagnosed by the melting temperature mapping method: A case report

Ikeda, S., Uchiyama, K., Moriya, M., Sakurai, K., Nihonyanagi, S., Niimi, H. & Takaso, M., 2023/11, In: Journal of Orthopaedic Science. 28, 6, p. 1497-1500 4 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Dominant CT Patterns and Immune Responses during the Early Infection Phases of Different SARS-CoV-2 Variants

Nagaoka, K., Kawasuji, H., Takegoshi, Y., Murai, Y., Kaneda, M., Kimoto, K., Tani, H., Niimi, H., Morinaga, Y., Noguchi, K. & Yamamoto, Y., 2023/05/31, In: Viruses. 15, 6, p. 1304-1304 1 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Duplex loop-mediated isothermal amplification assay for simultaneous detection of human and human male DNA

Kubo, S., Niimi, H. & Kitajima, I., 2023/12, In: BMC Research Notes. 16, 1, 180.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

1 被引用数 (Scopus)

High Incidence of Metastatic Infections in Panton-Valentine Leucocidin-Negative, Community-Acquired Methicillin-Resistant Staphylococcus aureus Bacteremia: An 11-Year Retrospective Study in Japan

Kawasuji, H., Ikezawa, Y., Morita, M., Sugie, K., Somekawa, M., Ezaki, M., Koshiyama, Y., Takegoshi, Y., Murai, Y., Kaneda, M., Kimoto, K., Nagaoka, K., Niimi, H., Morinaga, Y. & Yamamoto, Y., 2023/10, In: Antibiotics. 12, 10, 1516.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

1 被引用数 (Scopus)

Improved reverse transcription-recombinase polymerase amplification assay for blood mRNA screening: comparison with one-step RT-qPCR assay

Kubo, S., Niimi, H. & Kitajima, I., 2023/03, In: Forensic Science International: Genetics. 63, 102808.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

6 被引用数 (Scopus)

Loop-mediated isothermal amplification assay for fluorescence analysis and lateral flow detection of male DNA

Kubo, S., Niimi, H. & Kitajima, I., 2023/03/01, In: Analytical Biochemistry. 664, 115029.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

5 被引用数 (Scopus)

Neutralizing Antibody Response of the Wild-Type/Omicron BA.1 Bivalent Vaccine as the Second Booster Dose against Omicron BA.2 and BA.5

Kawasuji, H., Morinaga, Y., Tani, H., Saga, Y., Yamada, H., Yoshida, Y., Takegoshi, Y., Kaneda, M., Murai, Y., Kimoto, K., Ueno, A., Miyajima, Y., Nagaoka, K., Ono, C., Matsuura, Y., Niimi, H. & Yamamoto, Y., 2023/03, In: Microbiology Spectrum. 11, 2

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

6 被引用数 (Scopus)

Neutralizing Antibody Response of the Wild-Type/Omicron BA.1 Bivalent Vaccine as the Second Booster Dose against Omicron BA.2 and BA.5.

Kawasuji, H., Morinaga, Y., Tani, H., Saga, Y., Yamada, H., Yoshida, Y., Takegoshi, Y., Kaneda, M., Murai, Y., Kimoto, K., Ueno, A., Miyajima, Y., Nagaoka, K., Ono, C., Matsuura, Y., Niimi, H. & Yamamoto, Y., 2023/03/22, In: Microbiology Spectrum. 11, 2

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

One-tube, two-step isothermal amplification of histatin 3 mRNA for saliva screening

Kubo, S., Amai, K., Tanaka, J. & Niimi, H., 2023/11, In: Forensic Science International. 352, 111847.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Predictive value of cell population data with Sysmex XN-series hematology analyzer for culture-proven bacteremia

Miyajima, Y., Niimi, H., Ueno, T., Matsui, A., Higashi, Y., Kojima, N., Kono, M., Iwasaki, Y., Nagaoka, K., Yamamoto, Y. & Kitajima, I., 2023/06/01, In: Frontiers in Medicine. 10

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

2 被引用数 (Scopus)

Predictive values of immune indicators on respiratory failure in the early phase of COVID-19 due to Delta and precedent variants

Nagaoka, K., Kawasuji, H., Takegoshi, Y., Murai, Y., Kaneda, M., Kimoto, K., Morimoto, S., Tani, H., Niimi, H., Morinaga, Y. & Yamamoto, Y., 2023, In: Frontiers in Immunology. 14, 1197436.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

2 被引用数 (Scopus)

Progressive paravertebral ligament ossification and pseudoarthrosis in the thoracic spine due to loss of function of the PHEX gene in a patient with X-linked hypophosphatemic rickets

Yahara, Y., Niimi, H., Sugie, N., Seki, S., Ueshima, R., Makino, H., Kamei, K., Kitajima, I. & Kawaguchi, Y., 2023/01, In: Journal of Orthopaedic Science. 28, 1, p. 295-298 4 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

Sperm mRNA screening by reverse transcription-recombinase polymerase amplification (RT-RPA) assay: Decision-making for differential extraction

Kubo, S., Niimi, H. & Kitajima, I., 2023/06/01, In: Analytical Biochemistry. 670, 115121.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

1 被引用数 (Scopus)

肺動脈絞扼術後に合併したCorynebacterium属による感染性肺動脈瘤

西山真未, 田村賢太郎, 長岡貢秀, 猪又智実, 川﨑裕香子, 伊吹圭二郎, 小澤綾佳, 廣野恵一, 東田昭彦, 青木正哉, 芳村直樹, 仁井見英樹 & 吉田丈俊, 2023/04, In: 日本小児科学会雑誌 = The journal of the Japan Pediatric Society. 127, 4, p. 586-591 6 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

2022

Effectiveness of the third dose of BNT162b2 vaccine on neutralizing Omicron variant in the Japanese population

Kawasuji, H., Morinaga, Y., Tani, H., Saga, Y., Kaneda, M., Murai, Y., Ueno, A., Miyajima, Y., Fukui, Y., Nagaoka, K., Ono, C., Matsuura, Y., Niimi, H. & Yamamoto, Y., 2022/09, In: Journal of Infection and Chemotherapy. 28, 9, p. 1273-1278 6 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

7 被引用数 (Scopus)

Effectiveness of the third dose of BNT162b2 vaccine on neutralizing Omicron variant in the Japanese population

Kawasuji, H., Morinaga, Y., Tani, H., Saga, Y., Kaneda, M., Murai, Y., Ueno, A., Miyajima, Y., Fukui, Y., Nagaoka, K., Ono, C., Matsuura, Y., Niimi, H. & Yamamoto, Y., 2022/06, In: Journal of Infection and Chemotherapy.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Effect of Casirivimab/Imdevimab Treatment on Serum Type I Interferon Levels in SARS-CoV-2 Infection

Nagaoka, K., Kawasuji, H., Takegoshi, Y., Murai, Y., Kaneda, M., Ueno, A., Miyajima, Y., Niimi, H., Morinaga, Y. & Yamamoto, Y., 2022/06/27, In: Viruses. 14, 7, p. 1399-1399 1 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Effect of Casirivimab/Imdevimab Treatment on Serum Type I Interferon Levels in SARS-CoV-2 Infection

Nagaoka, K., Kawasuji, H., Takegoshi, Y., Murai, Y., Kaneda, M., Ueno, A., Miyajima, Y., Niimi, H., Morinaga, Y. & Yamamoto, Y., 2022/07, In: Viruses. 14, 7, 1399.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

4 被引用数 (Scopus)

Novel super-neutralizing antibody UT28K is capable of protecting against infection from a wide variety of SARS-CoV-2 variants

Ozawa, T., Tani, H., Anraku, Y., Kita, S., Igarashi, E., Saga, Y., Inasaki, N., Kawasuji, H., Yamada, H., Sasaki, S. I., Somekawa, M., Sasaki, J., Hayakawa, Y., Yamamoto, Y., Morinaga, Y., Kurosawa, N., Isobe, M., Fukuhara, H., Maenaka, K. & Hashiguchi, T. & 4 others, Kishi, H., Kitajima, I., Saito, S. & Niimi, H., 2022, In: mAbs. 14, 1, 2072455.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

8 被引用数 (Scopus)

Prospective Study of the Detection of Bacterial Pathogens in Pediatric Clinical Specimens Using the Melting Temperature Mapping Method

Uejima, Y., Suganuma, E., Ohnishi, T., Takei, H., Furuichi, M., Sato, S., Kawano, Y., Kitajima, I. & Niimi, H., 2022/06, In: Microbiology Spectrum. 10, 3

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

2 被引用数 (Scopus)

Purulent lymphadenitis due to Halomonas hamiltonii: a case report

Uejima, Y., Oh-Ishi, T., Kitajima, I. & Niimi, H., 2022/12, In: International Journal of Infectious Diseases. 125, p. 145-148 4 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

1 被引用数 (Scopus)

Rapid and direct detection of male DNA by recombinase polymerase amplification assay

Kubo, S., Niimi, H. & Kitajima, I., 2022/07, In: Forensic Science International: Genetics. 59, 102704.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

6 被引用数 (Scopus)

Rapid detection of blood and semen mRNA markers by reverse transcription-recombinase polymerase amplification

Kubo, S., Niimi, H. & Kitajima, I., 2022/05, In: Forensic Science International: Genetics. 58, 102665.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

11 被引用数 (Scopus)

2021

Age-Dependent Reduction in Neutralization against Alpha and Beta Variants of BNT162b2 SARS-CoV-2 Vaccine-Induced Immunity

Kawasuji, H., Morinaga, Y., Tani, H., Saga, Y., Kaneda, M., Murai, Y., Ueno, A., Miyajima, Y., Fukui, Y., Nagaoka, K., Ono, C., Matsuura, Y., Niimi, H. & Yamamoto, Y., 2021/12, In: Microbiology Spectrum. 9, 3, e00561.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

13 被引用数 (Scopus)

Increased cerebrospinal fluid adenosine 5'-triphosphate in patients with amyotrophic lateral sclerosis

Nukui, T., Matsui, A., Niimi, H., Sugimoto, T., Hayashi, T., Dougu, N., Konishi, H., Yamamoto, M., Anada, R., Matsuda, N., Kitajima, I. & Nakatsuji, Y., 2021/12, In: BMC Neurology. 21, 1, 255.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

6 被引用数 (Scopus)

Infected simple renal cyst due to Streptococcus pneumoniae rapidly diagnosed by the melting temperature mapping method: a case report

Uejima, Y., Niimi, H., Kato, R., Furuichi, M., Sato, S., Kitajima, I., Kawano, Y., Oh-Ishi, T., Kawashima, H. & Suganuma, E., 2021/12, In: BMC Pediatrics. 21, 1, 265.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

2 被引用数 (Scopus)

Pre-eclampsia Complicated With Maternal Renal Dysfunction Is Associated With Poor Neurological Development at 3 Years Old in Children Born Before 34 Weeks of Gestation

Yoneda, N., Yoneda, S., Tsuda, S., Ito, M., Shiozaki, A., Niimi, H., Yoshida, T., Nakashima, A. & Saito, S., 2021/04/29, In: Frontiers in Pediatrics. 9, 624323.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

3 被引用数 (Scopus)

2020

A rapid ATP bioluminescence-based test for detecting antibiotic resistance

Matsui, A., Kawabe, S. & Niimi, H., 2020, In: Japanese Journal of Clinical Chemistry. 49, 4, p. 258-264 7 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Bacteremia caused by Slackia exigua: A report of two cases and literature review

Kawasuji, H., Kaya, H., Kawamura, T., Ueno, A., Miyajima, Y., Tsuda, T., Taniguchi, H., Nakamura, M., Wada, A., Sakamaki, I., Niimi, H. & Yamamoto, Y., 2020/01, In: Journal of Infection and Chemotherapy. 26, 1, p. 119-123 5 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

10 被引用数 (Scopus)

Cerebrospinal fluid ATP as a potential biomarker in patients with mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke like episodes (MELAS)

Nukui, T., Matsui, A., Niimi, H., Yamamoto, M., Matsuda, N., Piao, J. L., Noguchi, K., Kitajima, I. & Nakatsuji, Y., 2020/01, In: Mitochondrion. 50, p. 145-148 4 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

8 被引用数 (Scopus)

Rapid Identification of Candida Species in Candidemia Directly from Blood Samples Using Imperfect Match Probes

Higashi, Y., Niimi, H., Sakamaki, I., Yamamoto, Y. & Kitajima, I., 2020/12/01, In: Scientific Reports. 10, 1, 5828.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

3 被引用数 (Scopus)

2019

A Rapid ATP Bioluminescence-based Test for Detecting Levofloxacin Resistance Starting from Positive Blood Culture Bottles

Matsui, A., Niimi, H., Uchiho, Y., Kawabe, S., Noda, H. & Kitajima, I., 2019/12/01, In: Scientific Reports. 9, 1, 13565.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

17 被引用数 (Scopus)

Pyogenic liver abscess due to hypervirulent Klebsiella pneumoniae in a 14-year-old boy

Sato, S., Aoyama, T., Uejima, Y., Furuichi, M., Suganuma, E., Takano, T., Ikeda, M., Mizoguchi, M., Okugawa, S., Moriya, K., Niimi, H., Kitajima, I., Kawashima, H. & Kawano, Y., 2019/02, In: Journal of Infection and Chemotherapy. 25, 2, p. 137-140 4 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

9 被引用数 (Scopus)

2018

17OHP-C in patients with spontaneous preterm labor and intact membranes: is there an effect according to the presence of intra-amniotic inflammation?

Yoneda, S., Yoneda, N., Shiozaki, A., Yoshino, O., Ueno, T., Niimi, H., Kitajima, I., Tamura, K., Kawasaki, Y., Makimoto, M., Yoshida, T. & Saito, S., 2018/09, In: American Journal of Reproductive Immunology. 80, 3, e12867.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

5 被引用数 (Scopus)

Factor X heterozygous mutation in a patient with potential risk of bleeding: A case report

Arita, K., Niimi, H., Yamagishi, N., Ueno, T., Kitajima, I. & Sugiyama, T., 2018/06/01, In: Medicine. 97, 23, e10950.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

2 被引用数 (Scopus)

Recurrent deep vein thrombosis with a protein S Tokushima mutation

Torai, R., Makino, T., Mizawa, M., Hayashi, M., Furukawa, F., Niimi, H. & Shimizu, T., 2018/01/01, In: British Journal of Dermatology. 178, 1, p. e7-e8

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Sludge reflects intra-amniotic inflammation with or without microorganisms

Yoneda, N., Yoneda, S., Niimi, H., Ito, M., Fukuta, K., Ueno, T., Ito, M., Shiozaki, A., Kigawa, M., Kitajima, I. & Saito, S., 2018/02, In: American Journal of Reproductive Immunology. 79, 2, e12807.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

23 被引用数 (Scopus)

2017

Spondylodiscitis due to Parvimonas micra diagnosed by the melting temperature mapping method: A case report

Higashi, Y., Nakamura, S., Niimi, H., Ueno, T., Matsumoto, K., Kawago, K., Sakamaki, I., Kitajima, I. & Yamamoto, Y., 2017/08/23, In: BMC Infectious Diseases. 17, 1, 584.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

11 被引用数 (Scopus)

2016

Antibiotic Therapy Increases the Risk of Preterm Birth in Preterm Labor without Intra-Amniotic Microbes, but may Prolong the Gestation Period in Preterm Labor with Microbes, Evaluated by Rapid and High-Sensitive PCR System

Yoneda, S., Shiozaki, A., Yoneda, N., Ito, M., Shima, T., Fukuda, K., Ueno, T., Niimi, H., Kitajima, I., Kigawa, M. & Saito, S., 2016/04/01, In: American Journal of Reproductive Immunology. 75, 4, p. 440-450 11 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

30 被引用数 (Scopus)

Cerebral venous sinus thrombosis in the patient with multiple sclerosis associated with congenital antithrombin deficiency

Kanaya, Y., Takamatsu, K., Shimoe, Y., Niimi, H., Kitajima, I. & Kuriyama, M., 2016, In: Clinical Neurology. 56, 4, p. 248-254 7 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

Polymicrobial Amniotic Fluid Infection with Mycoplasma/Ureaplasma and Other Bacteria Induces Severe Intra-Amniotic Inflammation Associated with Poor Perinatal Prognosis in Preterm Labor

Yoneda, N., Yoneda, S., Niimi, H., Ueno, T., Hayashi, S., Ito, M., Shiozaki, A., Urushiyama, D., Hata, K., Suda, W., Hattori, M., Kigawa, M., Kitajima, I. & Saito, S., 2016/02/01, In: American Journal of Reproductive Immunology. 75, 2, p. 112-125 14 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

48 被引用数 (Scopus)

臨床分子病態検査学講座

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