TY - JOUR
T1 - Vitreous chemokines and Sho (Zheng in Chinese) of Chinese-Korean-Japanese medicine in patients with diabetic vitreoretinopathy
AU - Hayasaka, Seiji
AU - Zhang, Xue Yun
AU - Cui, Hu Shan
AU - Yanagisawa, Shuichiro
AU - Chi, Zai Long
AU - Hayasaka, Yoriko
AU - Shimada, Yutaka
N1 - Funding Information:
This work was supported by a Grant-in Aid for the 21st Century COE Program from the Ministry of Education, Culture, Sports, Science and Technology, Japan.
PY - 2006
Y1 - 2006
N2 - We examined the levels of vitreous chemokines and Sho (Zheng in Chinese) of Chinese-Korean-Japanese medicine in diabetic patients. Patients undergoing vitrectomy were classified into Group 1 (no diabetic retinopathy), Group 2 (diabetic retinopathy with no or a few new vessels), and Group 3 (diabetic retinopathy with many new vessels). The levels of IL-8, MCP-1, MIP-1α, MIP-1β, and RANTES in the vitreous fluid were measured using cytometric bead array method. Sho was determined by the standard diagnostic method of Chinese-Korean-Japanese medicine. Vitreous levels of IL-8 and MCP-1 in Groups 2 and 3 were higher than those in Group 1. MIP-1α, MIP-1β, and RANTES levels in Groups 2 and 3 were almost the same as those in Group 1. The percentage of patients with Keishibukuryo-gan (Guizhifuling-wan in Chinese) sho in Group 3 was higher than that in Group 1. In conclusion, vitreous levels of IL-8 and MCP-1 were high in patients with diabetic vitreoretinopathy. Keishibukuryo-gan sho may be associated with diabetic vitreoretinopathy.
AB - We examined the levels of vitreous chemokines and Sho (Zheng in Chinese) of Chinese-Korean-Japanese medicine in diabetic patients. Patients undergoing vitrectomy were classified into Group 1 (no diabetic retinopathy), Group 2 (diabetic retinopathy with no or a few new vessels), and Group 3 (diabetic retinopathy with many new vessels). The levels of IL-8, MCP-1, MIP-1α, MIP-1β, and RANTES in the vitreous fluid were measured using cytometric bead array method. Sho was determined by the standard diagnostic method of Chinese-Korean-Japanese medicine. Vitreous levels of IL-8 and MCP-1 in Groups 2 and 3 were higher than those in Group 1. MIP-1α, MIP-1β, and RANTES levels in Groups 2 and 3 were almost the same as those in Group 1. The percentage of patients with Keishibukuryo-gan (Guizhifuling-wan in Chinese) sho in Group 3 was higher than that in Group 1. In conclusion, vitreous levels of IL-8 and MCP-1 were high in patients with diabetic vitreoretinopathy. Keishibukuryo-gan sho may be associated with diabetic vitreoretinopathy.
KW - Diabetic vitreoretinopathy
KW - Sho
KW - Vitreous chemokines
UR - http://www.scopus.com/inward/record.url?scp=33749468110&partnerID=8YFLogxK
U2 - 10.1142/S0192415X06004077
DO - 10.1142/S0192415X06004077
M3 - 学術論文
C2 - 16883625
AN - SCOPUS:33749468110
SN - 0192-415X
VL - 34
SP - 537
EP - 543
JO - American Journal of Chinese Medicine
JF - American Journal of Chinese Medicine
IS - 4
ER -
