TY - JOUR
T1 - Uric acid excretion increases during propofol anesthesia
AU - Masuda, Akira
AU - Asahi, Takehisa
AU - Sakamaki, Midori
AU - Nakamaru, Katsuhito
AU - Hirota, Koki
AU - Ito, Yusuke
PY - 1997
Y1 - 1997
N2 - We compared the effect of propofol with that of sevoflurane anesthesia on uric acid (UA) excretion in ASA physical status I and II patients with normal renal function. A propofol group (n = 11) received propofolnitrous oxide-fentanyl after induction of anesthesia by propofol, while a sevoflurane group (n = 12) received sevoflurane-nitrous oxide-fentanyl after induction of anesthesia by thiamylal. UA, creatinine (Cr), and urea nitrogen concentrations in serum and urine were measured before induction of anesthesia, 1, 2, and 3 h after induction, and on Postoperative Day 1. N- acetyl-β-D-glucosaminidase, β2-microglobulin concentrations, and pH in urine were also examined. Plasma clearance of UA (CUA) and Cr (CCr) were calculated. The hourlyconcentration and excretion of urine UA were significantly higher than those of the sevoflurane group (P < 0.01). Significant correlations were noted between the hourly urine volume and UA concentration (r = 0.58, P4 < 0.01 for the propofol group; r = 0.51, P < 0.01 for the sevoflurane group). The CUA of the propofol group was significantly higher than that of the sevoflurane group (22.9 ± 10.6 vs 5.9 ± 3.4 mL/min, mean ± SD, P <0.05). There were no significant differences in other renal variables between the two groups. The present study demonstrated that the UA excretion increased during propofol anesthesia, while it remained stable during sevoflurane anesthesia.
AB - We compared the effect of propofol with that of sevoflurane anesthesia on uric acid (UA) excretion in ASA physical status I and II patients with normal renal function. A propofol group (n = 11) received propofolnitrous oxide-fentanyl after induction of anesthesia by propofol, while a sevoflurane group (n = 12) received sevoflurane-nitrous oxide-fentanyl after induction of anesthesia by thiamylal. UA, creatinine (Cr), and urea nitrogen concentrations in serum and urine were measured before induction of anesthesia, 1, 2, and 3 h after induction, and on Postoperative Day 1. N- acetyl-β-D-glucosaminidase, β2-microglobulin concentrations, and pH in urine were also examined. Plasma clearance of UA (CUA) and Cr (CCr) were calculated. The hourlyconcentration and excretion of urine UA were significantly higher than those of the sevoflurane group (P < 0.01). Significant correlations were noted between the hourly urine volume and UA concentration (r = 0.58, P4 < 0.01 for the propofol group; r = 0.51, P < 0.01 for the sevoflurane group). The CUA of the propofol group was significantly higher than that of the sevoflurane group (22.9 ± 10.6 vs 5.9 ± 3.4 mL/min, mean ± SD, P <0.05). There were no significant differences in other renal variables between the two groups. The present study demonstrated that the UA excretion increased during propofol anesthesia, while it remained stable during sevoflurane anesthesia.
UR - http://www.scopus.com/inward/record.url?scp=0030814144&partnerID=8YFLogxK
U2 - 10.1097/00000539-199707000-00026
DO - 10.1097/00000539-199707000-00026
M3 - 学術論文
C2 - 9212138
AN - SCOPUS:0030814144
SN - 0003-2999
VL - 85
SP - 144
EP - 148
JO - Anesthesia and Analgesia
JF - Anesthesia and Analgesia
IS - 1
ER -