The use of formaldehyde in the rhodium-catalyzed linear-selective hydroformylation of vinylheteroarenes

Jian Pan, Tsumoru Morimoto*, Hideyuki Kobayashi, Hiroki Tanimoto, Kiyomi Kakiuchi

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

An accessible protocol for the linear-selective hydroformylation of vinylheteroarenes using formaldehyde as a substitute for syngas is reported. The simultaneous use of BIPHEP and Nixantphos ligands permitted a high regioselectivity (linear/branched = up to 93/7) and moderate yield of isolated product (up to 84%) to be obtained. Under such catalytic conditions, vinylheteroarenes containing a vinyl group at the 2-position in the heterocycle ring reacted more linear-selectively with formaldehyde than at the 3-position.

Original languageEnglish
Pages (from-to)519-533
Number of pages15
JournalHeterocycles
Volume98
Issue number4
DOIs
StatePublished - 2019

ASJC Scopus subject areas

  • Analytical Chemistry
  • Pharmacology
  • Organic Chemistry

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