Abstract
An accessible protocol for the linear-selective hydroformylation of vinylheteroarenes using formaldehyde as a substitute for syngas is reported. The simultaneous use of BIPHEP and Nixantphos ligands permitted a high regioselectivity (linear/branched = up to 93/7) and moderate yield of isolated product (up to 84%) to be obtained. Under such catalytic conditions, vinylheteroarenes containing a vinyl group at the 2-position in the heterocycle ring reacted more linear-selectively with formaldehyde than at the 3-position.
Original language | English |
---|---|
Pages (from-to) | 519-533 |
Number of pages | 15 |
Journal | Heterocycles |
Volume | 98 |
Issue number | 4 |
DOIs | |
State | Published - 2019 |
ASJC Scopus subject areas
- Analytical Chemistry
- Pharmacology
- Organic Chemistry