TY - JOUR
T1 - Surface morphology of the orbitofrontal cortex in individuals at risk of psychosis
T2 - a multicenter study
AU - Nakamura, Mihoko
AU - Takahashi, Tsutomu
AU - Takayanagi, Yoichiro
AU - Sasabayashi, Daiki
AU - Katagiri, Naoyuki
AU - Sakuma, Atsushi
AU - Obara, Chika
AU - Koike, Shinsuke
AU - Yamasue, Hidenori
AU - Furuichi, Atsushi
AU - Kido, Mikio
AU - Nishikawa, Yumiko
AU - Noguchi, Kyo
AU - Matsumoto, Kazunori
AU - Mizuno, Masafumi
AU - Kasai, Kiyoto
AU - Suzuki, Michio
N1 - Publisher Copyright:
© 2018, Springer-Verlag GmbH Germany, part of Springer Nature.
PY - 2019/6/1
Y1 - 2019/6/1
N2 - Changes in the surface morphology of the orbitofrontal cortex (OFC), such as a fewer orbital sulci and altered sulcogyral pattern of the ‘H-shaped’ orbital sulcus, have been reported in schizophrenia, possibly reflecting abnormal neurodevelopment during gestation. However, whether high-risk subjects for developing psychosis also exhibit these gross morphologic anomalies is not well documented. This multicenter MRI study from four scanning sites in Japan investigated the distribution of the number of intermediate and posterior orbital sulci, as well as the OFC sulcogyral pattern, in 125 individuals with an at-risk mental state (ARMS) [of whom 22 later developed psychosis (ARMS-P) and 89 did not (ARMS-NP)] and 110 healthy controls. The ARMS group as a whole had a significantly lower number of intermediate and posterior orbital sulci compared with the controls, which was associated with prodromal symptomatology. However, there was no group difference in OFC pattern distribution. The ARMS-P and -NP groups did not differ in OFC surface morphology. These results suggest that gross morphology of the OFC in high-risk subjects may at least partly reflect neurodevelopmental pathology related to vulnerability to psychosis.
AB - Changes in the surface morphology of the orbitofrontal cortex (OFC), such as a fewer orbital sulci and altered sulcogyral pattern of the ‘H-shaped’ orbital sulcus, have been reported in schizophrenia, possibly reflecting abnormal neurodevelopment during gestation. However, whether high-risk subjects for developing psychosis also exhibit these gross morphologic anomalies is not well documented. This multicenter MRI study from four scanning sites in Japan investigated the distribution of the number of intermediate and posterior orbital sulci, as well as the OFC sulcogyral pattern, in 125 individuals with an at-risk mental state (ARMS) [of whom 22 later developed psychosis (ARMS-P) and 89 did not (ARMS-NP)] and 110 healthy controls. The ARMS group as a whole had a significantly lower number of intermediate and posterior orbital sulci compared with the controls, which was associated with prodromal symptomatology. However, there was no group difference in OFC pattern distribution. The ARMS-P and -NP groups did not differ in OFC surface morphology. These results suggest that gross morphology of the OFC in high-risk subjects may at least partly reflect neurodevelopmental pathology related to vulnerability to psychosis.
KW - High-risk
KW - Magnetic resonance imaging
KW - Multicenter
KW - Orbitofrontal cortex
KW - Psychosis
KW - Sulcogyral pattern
UR - http://www.scopus.com/inward/record.url?scp=85044381023&partnerID=8YFLogxK
U2 - 10.1007/s00406-018-0890-6
DO - 10.1007/s00406-018-0890-6
M3 - 学術論文
C2 - 29572660
AN - SCOPUS:85044381023
SN - 0940-1334
VL - 269
SP - 397
EP - 406
JO - European Archives of Psychiatry and Clinical Neuroscience
JF - European Archives of Psychiatry and Clinical Neuroscience
IS - 4
ER -