TY - JOUR
T1 - Suicide attempt and n-3 fatty acid levels in red blood cells
T2 - A case control study in China
AU - Huan, Mingming
AU - Hamazaki, Kei
AU - Sun, Yueji
AU - Itomura, Miho
AU - Liu, Hongyan
AU - Kang, Wei
AU - Watanabe, Shiro
AU - Terasawa, Katsutoshi
AU - Hamazaki, Tomohito
N1 - Funding Information:
This study was supported in part by the Japan Society for the Promotion of Science and the Polyene Project Corporation. It was performed at Department of Neuropsychology, Dalian Medical University, Dalian-City, Liaoning-Province, China; Psychiatry Department, Dalian Friendship Hospital, Dalian-shi; and Dalian Blood Component Analysis Center, Dalian-shi.
PY - 2004/10/1
Y1 - 2004/10/1
N2 - Epidemiologic studies show that low fish intake is a risk factor of suicidality; however, there are no case-control studies investigating suicide attempt risk and tissue n-3 fatty acid levels. We recruited 100 suicide-attempt cases and another 100 control patients injured by accidents who were admitted to three hospitals affiliated with Dalian Medical University in Dalian, China. Case and control subjects were matched for age, gender, and smoking status. Those who were inebriated at the time of hospitalization were excluded. Blood was sampled immediately after admission to a hospital. Washed red blood cells (RBCs) were obtained, and the fatty acid composition of the total RBC phospholipid fraction was analyzed by gas chromatography. Eicosapentaenoic acid (EPA) levels in RBC in the case subjects were significantly lower than those of the control subjects (.74 ± .52% vs. 1.06 ± .62%, p < .0001). When the highest and lowest quartiles of EPA in RBC were compared, the odds ratios of suicide attempt was. 12 in the highest quartile (95% confidence interval: .04-.36, p for trend =. 0001) after adjustment for possible confounding factors Our findings suggest that low n-3 fatty acid levels in tissues were a risk factor of suicide attempt. Further studies including intervention with fish oil are warranted.
AB - Epidemiologic studies show that low fish intake is a risk factor of suicidality; however, there are no case-control studies investigating suicide attempt risk and tissue n-3 fatty acid levels. We recruited 100 suicide-attempt cases and another 100 control patients injured by accidents who were admitted to three hospitals affiliated with Dalian Medical University in Dalian, China. Case and control subjects were matched for age, gender, and smoking status. Those who were inebriated at the time of hospitalization were excluded. Blood was sampled immediately after admission to a hospital. Washed red blood cells (RBCs) were obtained, and the fatty acid composition of the total RBC phospholipid fraction was analyzed by gas chromatography. Eicosapentaenoic acid (EPA) levels in RBC in the case subjects were significantly lower than those of the control subjects (.74 ± .52% vs. 1.06 ± .62%, p < .0001). When the highest and lowest quartiles of EPA in RBC were compared, the odds ratios of suicide attempt was. 12 in the highest quartile (95% confidence interval: .04-.36, p for trend =. 0001) after adjustment for possible confounding factors Our findings suggest that low n-3 fatty acid levels in tissues were a risk factor of suicide attempt. Further studies including intervention with fish oil are warranted.
KW - Docosahexaenoic acid
KW - eicosapentaenoic acid
KW - fatty acid composition
KW - fish intake
KW - phospholipids
KW - suicide attempt
UR - http://www.scopus.com/inward/record.url?scp=4644219808&partnerID=8YFLogxK
U2 - 10.1016/j.biopsych.2004.06.028
DO - 10.1016/j.biopsych.2004.06.028
M3 - 学術論文
C2 - 15450784
AN - SCOPUS:4644219808
SN - 0006-3223
VL - 56
SP - 490
EP - 496
JO - Biological Psychiatry
JF - Biological Psychiatry
IS - 7
ER -
