Scutellariae Radix augments ulceration but attenuates proinflammatory cytokine and chemokine gene induction in the small intestine during indomethacin-induced enteropathy in mice

Shiro Watanabe; Yasuhiro Yamada; Kazuki Dobashi; Masataka Saito

doi:10.11339/jtm.25.55

Scutellariae Radix augments ulceration but attenuates proinflammatory cytokine and chemokine gene induction in the small intestine during indomethacin-induced enteropathy in mice

Shiro Watanabe^*, Yasuhiro Yamada, Kazuki Dobashi, Masataka Saito

^*Corresponding author for this work

Section of Host Defences, Division of Bioscience, Institute of Natural Medicine

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Our previous report described the enhancement of intestinal bleeding and anemia associated with indomethacin (INDO)-induced enteropathy in mice by oral administration of Scutellariae Radix (SR) extract. We here demonstrate that SR extract enhanced ulceration but attenuated the elevation of expression levels of interleukin (IL)-1β, IL-6 and CCL2 gene transcripts in the small intestine during INDO-induced enteropathy. Our observations further support that INDO-induced enteropathy is aggravated by the oral administration of SR extract. This effect of SR extract may be due to the modulation of immune-inflammatory processes possibly through the suppression of proinflammatory cytokine and chemokine induction.

Original language	English
Pages (from-to)	55-59
Number of pages	5
Journal	Journal of Traditional Medicines
Volume	25
Issue number	2
DOIs	https://doi.org/10.11339/jtm.25.55
State	Published - 2008

Keywords

chemokine
cyotkine
non-steroidal anti-inflammatory drug

ASJC Scopus subject areas

Drug Discovery
Complementary and alternative medicine

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10.11339/jtm.25.55

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title = "Scutellariae Radix augments ulceration but attenuates proinflammatory cytokine and chemokine gene induction in the small intestine during indomethacin-induced enteropathy in mice",

abstract = "Our previous report described the enhancement of intestinal bleeding and anemia associated with indomethacin (INDO)-induced enteropathy in mice by oral administration of Scutellariae Radix (SR) extract. We here demonstrate that SR extract enhanced ulceration but attenuated the elevation of expression levels of interleukin (IL)-1β, IL-6 and CCL2 gene transcripts in the small intestine during INDO-induced enteropathy. Our observations further support that INDO-induced enteropathy is aggravated by the oral administration of SR extract. This effect of SR extract may be due to the modulation of immune-inflammatory processes possibly through the suppression of proinflammatory cytokine and chemokine induction.",

keywords = "chemokine, cyotkine, non-steroidal anti-inflammatory drug",

author = "Shiro Watanabe and Yasuhiro Yamada and Kazuki Dobashi and Masataka Saito",

year = "2008",

doi = "10.11339/jtm.25.55",

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volume = "25",

pages = "55--59",

journal = "Journal of Traditional Medicines",

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publisher = "Medical and Pharmaceutical Society for WAKAN-YAKU",

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Scutellariae Radix augments ulceration but attenuates proinflammatory cytokine and chemokine gene induction in the small intestine during indomethacin-induced enteropathy in mice. / Watanabe, Shiro; Yamada, Yasuhiro; Dobashi, Kazuki et al.
In: Journal of Traditional Medicines, Vol. 25, No. 2, 2008, p. 55-59.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Scutellariae Radix augments ulceration but attenuates proinflammatory cytokine and chemokine gene induction in the small intestine during indomethacin-induced enteropathy in mice

AU - Watanabe, Shiro

AU - Yamada, Yasuhiro

AU - Dobashi, Kazuki

AU - Saito, Masataka

PY - 2008

Y1 - 2008

N2 - Our previous report described the enhancement of intestinal bleeding and anemia associated with indomethacin (INDO)-induced enteropathy in mice by oral administration of Scutellariae Radix (SR) extract. We here demonstrate that SR extract enhanced ulceration but attenuated the elevation of expression levels of interleukin (IL)-1β, IL-6 and CCL2 gene transcripts in the small intestine during INDO-induced enteropathy. Our observations further support that INDO-induced enteropathy is aggravated by the oral administration of SR extract. This effect of SR extract may be due to the modulation of immune-inflammatory processes possibly through the suppression of proinflammatory cytokine and chemokine induction.

AB - Our previous report described the enhancement of intestinal bleeding and anemia associated with indomethacin (INDO)-induced enteropathy in mice by oral administration of Scutellariae Radix (SR) extract. We here demonstrate that SR extract enhanced ulceration but attenuated the elevation of expression levels of interleukin (IL)-1β, IL-6 and CCL2 gene transcripts in the small intestine during INDO-induced enteropathy. Our observations further support that INDO-induced enteropathy is aggravated by the oral administration of SR extract. This effect of SR extract may be due to the modulation of immune-inflammatory processes possibly through the suppression of proinflammatory cytokine and chemokine induction.

KW - chemokine

KW - cyotkine

KW - non-steroidal anti-inflammatory drug

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U2 - 10.11339/jtm.25.55

DO - 10.11339/jtm.25.55

M3 - 学術論文

AN - SCOPUS:85024438649

SN - 1880-1447

VL - 25

SP - 55

EP - 59

JO - Journal of Traditional Medicines

JF - Journal of Traditional Medicines

IS - 2

ER -

Scutellariae Radix augments ulceration but attenuates proinflammatory cytokine and chemokine gene induction in the small intestine during indomethacin-induced enteropathy in mice

Abstract

Keywords

ASJC Scopus subject areas

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