Scutellariae Radix aggravates diclofenac sodium-induced enteropathy in mice

Kazuki Dobashi; Emika Ohkoshi; Yuichi Fujii; Masahiro Nagai; Shiro Watanabe

doi:10.11339/jtm.25.81

Scutellariae Radix aggravates diclofenac sodium-induced enteropathy in mice

Kazuki Dobashi, Emika Ohkoshi, Yuichi Fujii, Masahiro Nagai, Shiro Watanabe^*

^*Corresponding author for this work

Section of Host Defences, Division of Bioscience, Institute of Natural Medicine

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

We have reported that the oral administration of water extract of Scutellariae Radix (SR) enhances small intestinal ulceration and intestinal bleeding in the experimental enteropathy induced by subcutaneous injections of indomethacin (INDO) in mice. The present study was carried out to examine whether SR extract or SR-containing Kampo formula exerts similar effects in diclofenac sodium (Dic)-induced enteropathy in mice. We found that small intestinal ulceration and fecal hemoglobin (Hb) excretion in Dic-treated mice were enhanced by SR extract. However, such effects were not induced by pure baicalin (>97%, w/w). Orengedokuto (OGT) did not enhance small intestinal ulceration but significantly enhanced fecal Hb excretion in Dic-treated mice. Our observations suggest a possibility that SR-containing Kampo formulas could aggravate non-steroidal anti-inflammatory drug-induced enteropathy.

Original language	English
Pages (from-to)	81-86
Number of pages	6
Journal	Journal of Traditional Medicines
Volume	25
Issue number	3
DOIs	https://doi.org/10.11339/jtm.25.81
State	Published - 2008

Keywords

NSAIDs
baicalin
intestinal bleeding
orengedokuto
ulceration

ASJC Scopus subject areas

Drug Discovery
Complementary and alternative medicine

Access to Document

10.11339/jtm.25.81

Cite this

@article{8b27d87dc48349bfb5b5ca3b90258418,

title = "Scutellariae Radix aggravates diclofenac sodium-induced enteropathy in mice",

abstract = "We have reported that the oral administration of water extract of Scutellariae Radix (SR) enhances small intestinal ulceration and intestinal bleeding in the experimental enteropathy induced by subcutaneous injections of indomethacin (INDO) in mice. The present study was carried out to examine whether SR extract or SR-containing Kampo formula exerts similar effects in diclofenac sodium (Dic)-induced enteropathy in mice. We found that small intestinal ulceration and fecal hemoglobin (Hb) excretion in Dic-treated mice were enhanced by SR extract. However, such effects were not induced by pure baicalin (>97%, w/w). Orengedokuto (OGT) did not enhance small intestinal ulceration but significantly enhanced fecal Hb excretion in Dic-treated mice. Our observations suggest a possibility that SR-containing Kampo formulas could aggravate non-steroidal anti-inflammatory drug-induced enteropathy.",

keywords = "NSAIDs, baicalin, intestinal bleeding, orengedokuto, ulceration",

author = "Kazuki Dobashi and Emika Ohkoshi and Yuichi Fujii and Masahiro Nagai and Shiro Watanabe",

year = "2008",

doi = "10.11339/jtm.25.81",

language = "英語",

volume = "25",

pages = "81--86",

journal = "Journal of Traditional Medicines",

issn = "1880-1447",

publisher = "Medical and Pharmaceutical Society for WAKAN-YAKU",

number = "3",

}

TY - JOUR

T1 - Scutellariae Radix aggravates diclofenac sodium-induced enteropathy in mice

AU - Dobashi, Kazuki

AU - Ohkoshi, Emika

AU - Fujii, Yuichi

AU - Nagai, Masahiro

AU - Watanabe, Shiro

PY - 2008

Y1 - 2008

N2 - We have reported that the oral administration of water extract of Scutellariae Radix (SR) enhances small intestinal ulceration and intestinal bleeding in the experimental enteropathy induced by subcutaneous injections of indomethacin (INDO) in mice. The present study was carried out to examine whether SR extract or SR-containing Kampo formula exerts similar effects in diclofenac sodium (Dic)-induced enteropathy in mice. We found that small intestinal ulceration and fecal hemoglobin (Hb) excretion in Dic-treated mice were enhanced by SR extract. However, such effects were not induced by pure baicalin (>97%, w/w). Orengedokuto (OGT) did not enhance small intestinal ulceration but significantly enhanced fecal Hb excretion in Dic-treated mice. Our observations suggest a possibility that SR-containing Kampo formulas could aggravate non-steroidal anti-inflammatory drug-induced enteropathy.

AB - We have reported that the oral administration of water extract of Scutellariae Radix (SR) enhances small intestinal ulceration and intestinal bleeding in the experimental enteropathy induced by subcutaneous injections of indomethacin (INDO) in mice. The present study was carried out to examine whether SR extract or SR-containing Kampo formula exerts similar effects in diclofenac sodium (Dic)-induced enteropathy in mice. We found that small intestinal ulceration and fecal hemoglobin (Hb) excretion in Dic-treated mice were enhanced by SR extract. However, such effects were not induced by pure baicalin (>97%, w/w). Orengedokuto (OGT) did not enhance small intestinal ulceration but significantly enhanced fecal Hb excretion in Dic-treated mice. Our observations suggest a possibility that SR-containing Kampo formulas could aggravate non-steroidal anti-inflammatory drug-induced enteropathy.

KW - NSAIDs

KW - baicalin

KW - intestinal bleeding

KW - orengedokuto

KW - ulceration

UR - http://www.scopus.com/inward/record.url?scp=79959277906&partnerID=8YFLogxK

U2 - 10.11339/jtm.25.81

DO - 10.11339/jtm.25.81

M3 - 学術論文

AN - SCOPUS:79959277906

SN - 1880-1447

VL - 25

SP - 81

EP - 86

JO - Journal of Traditional Medicines

JF - Journal of Traditional Medicines

IS - 3

ER -

Scutellariae Radix aggravates diclofenac sodium-induced enteropathy in mice

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Fingerprint

Cite this