Review of stroke and myocardial infarction following intravitreal anti-VEGF treatment

Tomoko Nakamura*, Shinya Abe, Takaaki Yagou, Tomoko Consolvo-Ueda, Atsushi Hayashi

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

Purpose: To present a review of stroke and myocardial infarction following intravitreal anti-VEGF treatment. Cases and Method: This retrospective study was made on 960 patients who received intravitreal injection of anti-VEGF during the past 6 years at Toyama University Hospital. The series comprised 593 males and 367 females. The age averaged 70.9 years at the start of treatment. Results: Cerebral stroke developed in 11 cases (l.2%) and myocardial infarction developed in 3 cases (0.3%). Stroke of myocardial infarction developed in 5 cases within one month of vitreal injection of aflibercept as anti-VEGF. Conclusion: Stroke or myocardial infarction developed in 1.4% of cases receiving intravitreal anti-VEGF. Aflibercept appeared to be followed by cerebral or myocardial accidents within one month of treatment.

Original languageEnglish
Pages (from-to)551-557
Number of pages7
JournalJapanese Journal of Clinical Ophthalmology
Volume71
Issue number4
StatePublished - 2017/04

ASJC Scopus subject areas

  • Ophthalmology

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