Recent applications and developments of organic azides in total synthesis of natural products

Hiroki Tanimoto*, Kiyomi Kakiuchi

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

99 Scopus citations

Abstract

Organic azides have been exploited since their discovery because of their high reactivities. Various organic reactions using azides have been synthetically applied in chemical biology, pharmaceuticals, medicinal, and agricultural areas. In this review, we present some recent applications and developments of organic azides in the total synthesis of natural products (mostly within five years), especially alkaloids. We focus not only on application examples of organic azides, but also show their preparation methods including recently reported procedures concerning their decomposing and reducing methods in the syntheses of bioactive molecules.

Original languageEnglish
Pages (from-to)1021-1034
Number of pages14
JournalNatural Product Communications
Volume8
Issue number7
DOIs
StatePublished - 2013/07

Keywords

  • 1 3-dipolar cycloaddition
  • Alkaloids
  • Curtius rearrangement
  • Organic azides
  • Schmidt reaction
  • Staudinger-aza-wittig reaction
  • Total synthesis

ASJC Scopus subject areas

  • Pharmacology
  • Plant Science
  • Drug Discovery
  • Complementary and alternative medicine

Fingerprint

Dive into the research topics of 'Recent applications and developments of organic azides in total synthesis of natural products'. Together they form a unique fingerprint.

Cite this