Prognostic impact of renal sinus fat accumulation in patients with chronic kidney disease

Hayato Fujioka, Tsutomu Koike, Teruhiko Imamura*, Kota Kakeshita, Hidenori Yamazaki, Koichiro Kinugawa

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Background: Obesity is associated with the development and progression of chronic kidney disease (CKD). In the general population, the amount of renal sinus fat was associated with hypertension and renal impairment. However, its impact upon those with CKD remains uncertain. Methods: We prospectively included CKD patients who underwent renal biopsy and simultaneously measured their renal sinus fat volume. The association between the percentage of renal sinus fat volume, which was adjusted by kidney volume, and renal outcomes was investigated. Results: A total of 56 patients (median 55 years old, 35 men) were included. Among baseline characteristics, age and visceral fat volume were positively correlated with the percentage of renal sinus fat volume (p < 0.05). The percentage of renal sinus fat volume was associated with hypertension (p < 0.01) and tended to be associated with max glomerular diameter (p = 0.078) and urine angiotensinogen creatinine ratio (p = 0.064) after adjustment with several clinical factors. The percentage of renal sinus fat volume was significantly associated with a future > 50% decline in estimated glomerular filtration rate (p < 0.05). Conclusions: Among those with CKD who required renal biopsy, the amount of renal sinus fat was associated with poor renal outcomes accompanied by systemic hypertension.

Original languageEnglish
Pages (from-to)613-621
Number of pages9
JournalClinical and Experimental Nephrology
Volume27
Issue number7
DOIs
StatePublished - 2023/07

Keywords

  • Chronic kidney disease
  • Hypertension
  • Obesity
  • Renal sinus fat

ASJC Scopus subject areas

  • Physiology
  • Nephrology
  • Physiology (medical)

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