Pre-disease Detection Using Dynamical Network Biomarkers in Gene Regulatory Networks with Cell-to-cell Interaction

Y. Saito; H. Sasahara; X. Shen; J. Peña Ramirez; J. Imura; M. Oku; K. Aihara

doi:10.1016/j.ifacol.2023.10.859

Pre-disease Detection Using Dynamical Network Biomarkers in Gene Regulatory Networks with Cell-to-cell Interaction

Y. Saito^*, H. Sasahara^*, X. Shen^*, J. Peña Ramirez^*, J. Imura^*, M. Oku, K. Aihara

^*Corresponding author for this work

Research Center for Pre-Disease Science

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

1 Scopus citations

Abstract

Dynamical Network Biomarkers (DNB) theory has been proposed as a method for detecting diseases at a very early stage. The progression of a disease can be regarded as a bifurcation phenomenon of the underlying dynamical system associated with the corresponding gene network. By identifying large fluctuations of the gene expression level occurring just before the bifurcation, we can detect the pre-disease stage without identifying the mathematical model of the dynamical system. However, the existing DNB theory mainly focuses on a single gene network representing averaged dynamics of multiple cells not explicitly handling a group of cells with cell-to-cell interaction. In this study, we extend the DNB theory to the case where cell-to-cell interaction is also taken into account. Ultimately, our analysis reveals that the pre-disease stage can be detected from the observation of the average gene expression when the bifurcation is induced by the intrinsic dynamics of the cells, whereas it remains undetectable when the bifurcation is produced by the interaction.

Original language	English
Title of host publication	IFAC-PapersOnLine
Editors	Hideaki Ishii, Yoshio Ebihara, Jun-ichi Imura, Masaki Yamakita
Publisher	Elsevier B.V.
Pages	6459-6464
Number of pages	6
Edition	2
ISBN (Electronic)	9781713872344
DOIs	https://doi.org/10.1016/j.ifacol.2023.10.859
State	Published - 2023/07/01
Event	22nd IFAC World Congress - Yokohama, Japan Duration: 2023/07/09 → 2023/07/14

Publication series

Name	IFAC-PapersOnLine
Number	2
Volume	56
ISSN (Electronic)	2405-8963

Conference

Conference	22nd IFAC World Congress
Country/Territory	Japan
City	Yokohama
Period	2023/07/09 → 2023/07/14

Keywords

Cell-to-cell interaction
dynamical network biomarker
gene regulatory networks

ASJC Scopus subject areas

Control and Systems Engineering

Access to Document

10.1016/j.ifacol.2023.10.859

Cite this

Saito, Y., Sasahara, H., Shen, X., Peña Ramirez, J., Imura, J., Oku, M., & Aihara, K. (2023). Pre-disease Detection Using Dynamical Network Biomarkers in Gene Regulatory Networks with Cell-to-cell Interaction. In H. Ishii, Y. Ebihara, J. Imura, & M. Yamakita (Eds.), IFAC-PapersOnLine (2 ed., pp. 6459-6464). (IFAC-PapersOnLine; Vol. 56, No. 2). Elsevier B.V.. https://doi.org/10.1016/j.ifacol.2023.10.859

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note = "Publisher Copyright: Copyright {\textcopyright} 2023 The Authors. This is an open access article under the CC BY-NC-ND license (https://creativecommons.org/licenses/by-nc-nd/4.0/); 22nd IFAC World Congress ; Conference date: 09-07-2023 Through 14-07-2023",

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Saito, Y, Sasahara, H, Shen, X, Peña Ramirez, J, Imura, J, Oku, M & Aihara, K 2023, Pre-disease Detection Using Dynamical Network Biomarkers in Gene Regulatory Networks with Cell-to-cell Interaction. in H Ishii, Y Ebihara, J Imura & M Yamakita (eds), IFAC-PapersOnLine. 2 edn, IFAC-PapersOnLine, no. 2, vol. 56, Elsevier B.V., pp. 6459-6464, 22nd IFAC World Congress, Yokohama, Japan, 2023/07/09. https://doi.org/10.1016/j.ifacol.2023.10.859

Pre-disease Detection Using Dynamical Network Biomarkers in Gene Regulatory Networks with Cell-to-cell Interaction. / Saito, Y.; Sasahara, H.; Shen, X. et al.
IFAC-PapersOnLine. ed. / Hideaki Ishii; Yoshio Ebihara; Jun-ichi Imura; Masaki Yamakita. 2. ed. Elsevier B.V., 2023. p. 6459-6464 (IFAC-PapersOnLine; Vol. 56, No. 2).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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AU - Imura, J.

AU - Oku, M.

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A2 - Ebihara, Yoshio

A2 - Imura, Jun-ichi

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PB - Elsevier B.V.

T2 - 22nd IFAC World Congress

Y2 - 9 July 2023 through 14 July 2023

ER -

Pre-disease Detection Using Dynamical Network Biomarkers in Gene Regulatory Networks with Cell-to-cell Interaction

Abstract

Publication series

Conference

Keywords

ASJC Scopus subject areas

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