TY - JOUR
T1 - Pre-conception status, obstetric outcome and use of medications during pregnancy of systemic lupus erythematosus (SLE), rheumatoid arthritis (RA) and inflammatory bowel disease (IBD) in Japan
T2 - Multi-center retrospective descriptive study
AU - for The Ministry of Health Labour and Welfare Working Group for “Guideline for The Treatment of Rheumatoid Arthritis or Inflammatory Bowel Disease Bearing Women in Child-bearing Age”
AU - Tsuda, Sayaka
AU - Sameshima, Azusa
AU - Sekine, Michikazu
AU - Kawaguchi, Haruna
AU - Fujita, Daisuke
AU - Makino, Shintaro
AU - Morinobu, Akio
AU - Murakawa, Yohko
AU - Matsui, Kiyoshi
AU - Sugiyama, Takao
AU - Watanabe, Mamoru
AU - Suzuki, Yasuo
AU - Nagahori, Masakazu
AU - Murashima, Atsuko
AU - Atsumi, Tatsuya
AU - Oku, Kenji
AU - Mitsuda, Nobuaki
AU - Takei, Syuji
AU - Miyamae, Takako
AU - Takahashi, Naoto
AU - Nakajima, Ken
AU - Saito, Shigeru
N1 - Publisher Copyright:
© 2019 Japan College of Rheumatology.
PY - 2020/9/2
Y1 - 2020/9/2
N2 - Objective: To describe the pre-conception status, pregnancy outcomes, and medication prevalence in systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), Crohn’s disease (CD), and ulcerative colitis (UC). Methods: E-mail-based questionnaire survey for the Japan Maternal Fetal Intensive Care Unit Network hospitals inquiring prevalence and clinical features of SLE, RA, CD and UC complicated pregnancies for 2 years. Results: The number of SLE, RA, CD and UC among 69,810 deliveries was 184, 139, 27 and 178, respectively. Less than half of pregnancies were planned. Assisted reproductive technology (ART) pregnancy rates were higher in SLE, RA and UC than in the general population (11.4, 23.0 and 7.4 vs 5.1%, p <.001 each). Preterm delivery, preeclampsia, and fetal growth restriction (FGR) were more frequent in SLE than in the general population (39.4 vs. 5.6% p <.001, 15.0 vs. 6.0% p <.001, 12.9 vs 4.2% p <.001). Prevalence of preterm delivery in RA and UC (27.5 vs. 5.6% p <.001, 11.3 vs. 5.6% p <.05) and FGR in CD (28.6 vs. 4.2% p <.001) was also higher than that in the general population. Conclusion: SLE, RA, CD, and UC complicated pregnancies were at high risks of obstetric adverse outcome. High ART rates necessitate pre-conception counseling in SLE, RA, and UC pregnancies.
AB - Objective: To describe the pre-conception status, pregnancy outcomes, and medication prevalence in systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), Crohn’s disease (CD), and ulcerative colitis (UC). Methods: E-mail-based questionnaire survey for the Japan Maternal Fetal Intensive Care Unit Network hospitals inquiring prevalence and clinical features of SLE, RA, CD and UC complicated pregnancies for 2 years. Results: The number of SLE, RA, CD and UC among 69,810 deliveries was 184, 139, 27 and 178, respectively. Less than half of pregnancies were planned. Assisted reproductive technology (ART) pregnancy rates were higher in SLE, RA and UC than in the general population (11.4, 23.0 and 7.4 vs 5.1%, p <.001 each). Preterm delivery, preeclampsia, and fetal growth restriction (FGR) were more frequent in SLE than in the general population (39.4 vs. 5.6% p <.001, 15.0 vs. 6.0% p <.001, 12.9 vs 4.2% p <.001). Prevalence of preterm delivery in RA and UC (27.5 vs. 5.6% p <.001, 11.3 vs. 5.6% p <.05) and FGR in CD (28.6 vs. 4.2% p <.001) was also higher than that in the general population. Conclusion: SLE, RA, CD, and UC complicated pregnancies were at high risks of obstetric adverse outcome. High ART rates necessitate pre-conception counseling in SLE, RA, and UC pregnancies.
KW - Crohn’s disease
KW - pregnancy
KW - rheumatoid arthritis
KW - systemic lupus erythematosus
KW - ulcerative colitis
UR - http://www.scopus.com/inward/record.url?scp=85073988077&partnerID=8YFLogxK
U2 - 10.1080/14397595.2019.1661592
DO - 10.1080/14397595.2019.1661592
M3 - 学術論文
C2 - 31483178
AN - SCOPUS:85073988077
SN - 1439-7595
VL - 30
SP - 852
EP - 861
JO - Modern Rheumatology
JF - Modern Rheumatology
IS - 5
ER -