Pituitary adenylate cyclase-activating polypeptide

Tomoya Nakamachi

doi:10.1016/B978-0-12-820649-2.00068-1

Pituitary adenylate cyclase-activating polypeptide

Tomoya Nakamachi^*

^*Corresponding author for this work

Department of Biology

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

PACAP was first isolated from the ovine hypothalamus with potency for cAMP elevation of pituitary cells. The PACAP precursor is cleaved by prohormone convertases to generate two types of PACAP forms, PACAP27 and PACAP38. PACAP is widely present in vertebrates, maintaining high homology. It is abundantly expressed in nervous tissues, and is also detected in the testis, adrenal gland, intestine, and pancreas. PACAP has pleiotropic functions as a neurotransmitter, neuroprotectant, and neurite outgrowth factor in nervous tissues, and as a vasodilator, smooth muscle relaxant, adrenergic and insulin secretagogues, and inducer of spermatogenesis in peripheral tissues. The PACAP knockout mouse shows many phenotypes, such as weakened neurons, abnormalities of circadian rhythm, delayed development of the cerebellum, abnormal metabolic and hormone levels, high mortality in newborns, impairment of memory and learning, and schizophrenia-related behavior.

Original language	English
Title of host publication	Handbook of Hormones
Subtitle of host publication	Comparative Endocrinology for Basic and Clinical Research
Publisher	Elsevier
Pages	259-261
Number of pages	3
ISBN (Electronic)	9780128206492
DOIs	https://doi.org/10.1016/B978-0-12-820649-2.00068-1
State	Published - 2021/01/01

Keywords

Abnormal behavior
Neural development
Neuropeptide
Neuroprotectant
PAC1R
cAMP inducer

ASJC Scopus subject areas

General Medicine

Access to Document

10.1016/B978-0-12-820649-2.00068-1

Cite this

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abstract = "PACAP was first isolated from the ovine hypothalamus with potency for cAMP elevation of pituitary cells. The PACAP precursor is cleaved by prohormone convertases to generate two types of PACAP forms, PACAP27 and PACAP38. PACAP is widely present in vertebrates, maintaining high homology. It is abundantly expressed in nervous tissues, and is also detected in the testis, adrenal gland, intestine, and pancreas. PACAP has pleiotropic functions as a neurotransmitter, neuroprotectant, and neurite outgrowth factor in nervous tissues, and as a vasodilator, smooth muscle relaxant, adrenergic and insulin secretagogues, and inducer of spermatogenesis in peripheral tissues. The PACAP knockout mouse shows many phenotypes, such as weakened neurons, abnormalities of circadian rhythm, delayed development of the cerebellum, abnormal metabolic and hormone levels, high mortality in newborns, impairment of memory and learning, and schizophrenia-related behavior.",

keywords = "Abnormal behavior, Neural development, Neuropeptide, Neuroprotectant, PAC1R, cAMP inducer",

author = "Tomoya Nakamachi",

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doi = "10.1016/B978-0-12-820649-2.00068-1",

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AB - PACAP was first isolated from the ovine hypothalamus with potency for cAMP elevation of pituitary cells. The PACAP precursor is cleaved by prohormone convertases to generate two types of PACAP forms, PACAP27 and PACAP38. PACAP is widely present in vertebrates, maintaining high homology. It is abundantly expressed in nervous tissues, and is also detected in the testis, adrenal gland, intestine, and pancreas. PACAP has pleiotropic functions as a neurotransmitter, neuroprotectant, and neurite outgrowth factor in nervous tissues, and as a vasodilator, smooth muscle relaxant, adrenergic and insulin secretagogues, and inducer of spermatogenesis in peripheral tissues. The PACAP knockout mouse shows many phenotypes, such as weakened neurons, abnormalities of circadian rhythm, delayed development of the cerebellum, abnormal metabolic and hormone levels, high mortality in newborns, impairment of memory and learning, and schizophrenia-related behavior.

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KW - Neural development

KW - Neuropeptide

KW - Neuroprotectant

KW - PAC1R

KW - cAMP inducer

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Pituitary adenylate cyclase-activating polypeptide

Abstract

Keywords

ASJC Scopus subject areas

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