@inproceedings{b25dfe4b2dbb4c51aa490e82930e1233,
title = "Pathological analysis of degenerative changes in humeral osteoarthritis using Raman spectroscopy",
abstract = "Osteoarthritis is the most common disease in articular cartilage. Raman spectroscopy is a promising tool for early detection of degenerative changes in cartilage matrix. In this study, surgically resected humeral heads of 14 patients were subjected to pathological analysis using Raman spectroscopy with principal component analysis and hierarchical clustering analysis. In the result, Raman spectral data of each specimen were divided into three major cluster reflecting the alteration in molecular composition of cartilage matrix. We also found histological characteristics in the cluster, suggesting that Raman spectrum is a biomarker to determine the condition of the cartilage tissue.",
keywords = "Raman, cartilage, osteoarthritis",
author = "Ryuji Asaoka and Hiroshi Kiyomatsu and Akihiro Jono and Masaki Takao and Takashi Katagiri and Yusuke Oshima",
note = "Publisher Copyright: {\textcopyright} 2023 SPIE.; Multiscale Imaging and Spectroscopy IV 2023 ; Conference date: 28-01-2023 Through 29-01-2023",
year = "2023",
doi = "10.1117/12.2650088",
language = "英語",
series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",
publisher = "SPIE",
editor = "Campagnola, {Paul J.} and Roblyer, {Darren M.} and Walsh, {Alex J.}",
booktitle = "Multiscale Imaging and Spectroscopy IV",
}