Abstract
Neurotensin (NT) was originally isolated from extracts of bovine hypothalamus in 1973, based on hypotensive action and peripheral vasodilation. The highly conserved C-terminal portion (8-13) of NT is responsible for its biological activities. NT is a neuromodulator of dopamine transmission and anterior pituitary hormone release, and exerts potent hypothermic and analgesic effects in the brain. In the periphery, NT acts as an endocrine modulator of the digestive tract and cardiovascular system, and as a growth factor on various normal or cancer cells. These functions are regulated via three receptors, NTR1, NTR2, and NTR3. NT is related to the pathophysiology of a series of disorders such as schizophrenia, drug abuse, Parkinson’s disease (PD), feeding disorders, cancer, cerebral stroke, and other neurodegenerative diseases. Furthermore, NT is involved in the physiology of pain induction, the central control of blood pressure, and inflammation.
| Original language | English |
|---|---|
| Title of host publication | Handbook of Hormones |
| Subtitle of host publication | Comparative Endocrinology for Basic and Clinical Research |
| Publisher | Elsevier |
| Pages | 145-148 |
| Number of pages | 4 |
| ISBN (Electronic) | 9780128206492 |
| DOIs | |
| State | Published - 2021/01/01 |
Keywords
- Hypotensive effect
- Neurotensin (NT)
- Neurotensin receptor (NTR)
ASJC Scopus subject areas
- General Medicine
