Neuropeptide S

Norifumi Konno

doi:10.1016/B978-0-12-820649-2.00041-3

Neuropeptide S

Norifumi Konno^*

^*Corresponding author for this work

Department of Biology

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

Neuropeptide S (NPS) was originally identified as the endogenous ligand of an orphan G-protein-coupled receptor (GRP154: NPSR) in 2004. NPS is a 20 amino acid peptide that is highly conserved among tetrapod vertebrates but is absent from fish genomes. The perfect conservation of the first seven amino acids (SFRNGVG) of NPS across all tetrapod species reflects the structural constraints for biological activity. NPS is involved in arousal, wakefulness, anxiolytic-like behaviors, fear, and learning and memory processes. These functions are regulated via two variants of NPSR. NPSR is functionally coupled with Gq and Gs, and its activation leads to the intracellular mobilization of Ca²⁺ and the formation of cAMP in cell line-expressed NPSR. NPS is related to the pathophysiology of a series of disorders such as generalized anxiety disorder (GAD), asthma, inflammatory bowel disease, and rheumatoid arthritis.

Original language	English
Title of host publication	Handbook of Hormones
Subtitle of host publication	Comparative Endocrinology for Basic and Clinical Research
Publisher	Elsevier
Pages	153-155
Number of pages	3
ISBN (Electronic)	9780128206492
DOIs	https://doi.org/10.1016/B978-0-12-820649-2.00041-3
State	Published - 2021/01/01

Keywords

20 Amino acid peptide
Anxiolytic behavior
Fear
GPR154
NPSR
Wakefulness

ASJC Scopus subject areas

General Medicine

Access to Document

10.1016/B978-0-12-820649-2.00041-3

Cite this

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abstract = "Neuropeptide S (NPS) was originally identified as the endogenous ligand of an orphan G-protein-coupled receptor (GRP154: NPSR) in 2004. NPS is a 20 amino acid peptide that is highly conserved among tetrapod vertebrates but is absent from fish genomes. The perfect conservation of the first seven amino acids (SFRNGVG) of NPS across all tetrapod species reflects the structural constraints for biological activity. NPS is involved in arousal, wakefulness, anxiolytic-like behaviors, fear, and learning and memory processes. These functions are regulated via two variants of NPSR. NPSR is functionally coupled with Gq and Gs, and its activation leads to the intracellular mobilization of Ca2+ and the formation of cAMP in cell line-expressed NPSR. NPS is related to the pathophysiology of a series of disorders such as generalized anxiety disorder (GAD), asthma, inflammatory bowel disease, and rheumatoid arthritis.",

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author = "Norifumi Konno",

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doi = "10.1016/B978-0-12-820649-2.00041-3",

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AB - Neuropeptide S (NPS) was originally identified as the endogenous ligand of an orphan G-protein-coupled receptor (GRP154: NPSR) in 2004. NPS is a 20 amino acid peptide that is highly conserved among tetrapod vertebrates but is absent from fish genomes. The perfect conservation of the first seven amino acids (SFRNGVG) of NPS across all tetrapod species reflects the structural constraints for biological activity. NPS is involved in arousal, wakefulness, anxiolytic-like behaviors, fear, and learning and memory processes. These functions are regulated via two variants of NPSR. NPSR is functionally coupled with Gq and Gs, and its activation leads to the intracellular mobilization of Ca2+ and the formation of cAMP in cell line-expressed NPSR. NPS is related to the pathophysiology of a series of disorders such as generalized anxiety disorder (GAD), asthma, inflammatory bowel disease, and rheumatoid arthritis.

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KW - Fear

KW - GPR154

KW - NPSR

KW - Wakefulness

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BT - Handbook of Hormones

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Neuropeptide S

Abstract

Keywords

ASJC Scopus subject areas

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