Abstract
An 83-year-old woman with a 1-year history of scheduled intravitreal injection of vascular endothelial growth factor (VEGF) inhibitor (aflibercept) was diagnosed with nephrotic syndrome due to focal segmental glomerulosclerosis with histopathological findings of segmental infiltration of foam cells in the glomerular capillaries. Her nephrotic syndrome improved immediately following the termination of aflibercept intravitreal injection without steroid therapy. Although widely used to treat ophthalmic diseases, we should keep in mind that even intravitreal injection of VEGF inhibitor, as opposed to systemic administration, can cause kidney injury.
Original language | English |
---|---|
Pages (from-to) | 3051-3054 |
Number of pages | 4 |
Journal | Internal Medicine |
Volume | 59 |
Issue number | 23 |
DOIs | |
State | Published - 2020/12/01 |
Keywords
- Aflibercept
- Podocyte
- Proteinuria
- VEGF inhibitor
ASJC Scopus subject areas
- Internal Medicine