TY - JOUR
T1 - LORETA analysis of three-dimensional distribution of delta band activity in schizophrenia
T2 - Relation to negative symptoms
AU - Itoh, Toru
AU - Sumiyoshi, Tomiki
AU - Higuchi, Yuko
AU - Suzuki, Michio
AU - Kawasaki, Yasuhiro
N1 - Funding Information:
This work was supported by Health and Labour Sciences Research Grants from the Ministry of Health, Labour, and Welfare , and by grants-in-aid for Scientific Research from the Japan Society for the Promotion of Science to Tomiki Sumiyoshi.
PY - 2011/8
Y1 - 2011/8
N2 - We sought to determine if altered electroencephalography (EEG) activities, such as delta band activity, in specific brain regions are associated with psychotic symptoms. Data were obtained from 17 neuroleptic-naive patients with schizophrenia and age- and sex-matched 17 healthy control subjects. Low Resolution Brain Electromagnetic Tomography (LORETA) was used to generate current source density images of delta, theta, alpha, and beta activities. Localization of the difference in EEG activity between the two groups was assessed by voxel-by-voxel non-paired t-test of the LORETA images. Spearman's correlation coefficient was obtained to relate LORETA values of EEG current density in brain regions showing a significant between-group difference and psychopathology scores. Delta band activity, represented by LORETA current density, was greater for patients in the following areas; the left inferior temporal gyrus, right middle frontal gyrus, right superior frontal gyrus, right inferior frontal gyrus, and right parahippocampal gyrus. LORETA values for delta band activity in the above five brain regions were negatively correlated with negative, but not positive symptoms. The results of this study suggest the role for electrophysiological changes in some of the brain regions, e.g. prefrontal cortex, in the manifestation of negative symptoms.
AB - We sought to determine if altered electroencephalography (EEG) activities, such as delta band activity, in specific brain regions are associated with psychotic symptoms. Data were obtained from 17 neuroleptic-naive patients with schizophrenia and age- and sex-matched 17 healthy control subjects. Low Resolution Brain Electromagnetic Tomography (LORETA) was used to generate current source density images of delta, theta, alpha, and beta activities. Localization of the difference in EEG activity between the two groups was assessed by voxel-by-voxel non-paired t-test of the LORETA images. Spearman's correlation coefficient was obtained to relate LORETA values of EEG current density in brain regions showing a significant between-group difference and psychopathology scores. Delta band activity, represented by LORETA current density, was greater for patients in the following areas; the left inferior temporal gyrus, right middle frontal gyrus, right superior frontal gyrus, right inferior frontal gyrus, and right parahippocampal gyrus. LORETA values for delta band activity in the above five brain regions were negatively correlated with negative, but not positive symptoms. The results of this study suggest the role for electrophysiological changes in some of the brain regions, e.g. prefrontal cortex, in the manifestation of negative symptoms.
KW - Delta band activity
KW - Electroencephalography
KW - LORETA
KW - Negative symptoms
KW - Prefrontal cortex
KW - Schizophrenia
UR - http://www.scopus.com/inward/record.url?scp=79960023246&partnerID=8YFLogxK
U2 - 10.1016/j.neures.2011.05.003
DO - 10.1016/j.neures.2011.05.003
M3 - 学術論文
C2 - 21641943
AN - SCOPUS:79960023246
SN - 0168-0102
VL - 70
SP - 442
EP - 448
JO - Neuroscience Research
JF - Neuroscience Research
IS - 4
ER -