Liver Cirrhosis

Terumi Takahara; Masaki Iwai; Wilson M.S. Tsui

doi:10.1007/978-981-13-6806-6_6

Liver Cirrhosis

Terumi Takahara^*, Masaki Iwai, Wilson M.S. Tsui

^*Corresponding author for this work

Department of Advanced Technology for Gastroenterological Cancer Therapy

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

Liver cirrhosis is anatomically defined as a diffuse disruption of the normal architecture of the liver with fibrosis and nodule formation. It is the end result of fibrogenesis caused by chronic liver injury. The anatomical architecture is the same with any etiology: continuous inflammation or hepatocyte damage causes fibrogenesis, and fibers extend from central or portal area, and finally fibrous septa is completely formed to surround regenerative nodules. Thus liver cirrhosis is characterized with hepatocyte dysfunction and portal hypertension.

Original language	English
Title of host publication	Diagnosis of Liver Disease, Second Edition
Publisher	Springer Singapore
Pages	61-73
Number of pages	13
ISBN (Electronic)	9789811368066
ISBN (Print)	9789811368059
DOIs	https://doi.org/10.1007/978-981-13-6806-6_6
State	Published - 2019/01/01

Keywords

Child-Pugh classification
Elastography
Fibrogenesis
Hepatic stellate cell
Hepatorenal syndrome
MELD score
Macronodule
Micronodule
Reversibility
Spontaneous bacterial peritonitis

ASJC Scopus subject areas

General Medicine

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10.1007/978-981-13-6806-6_6

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title = "Liver Cirrhosis",

abstract = "Liver cirrhosis is anatomically defined as a diffuse disruption of the normal architecture of the liver with fibrosis and nodule formation. It is the end result of fibrogenesis caused by chronic liver injury. The anatomical architecture is the same with any etiology: continuous inflammation or hepatocyte damage causes fibrogenesis, and fibers extend from central or portal area, and finally fibrous septa is completely formed to surround regenerative nodules. Thus liver cirrhosis is characterized with hepatocyte dysfunction and portal hypertension.",

keywords = "Child-Pugh classification, Elastography, Fibrogenesis, Hepatic stellate cell, Hepatorenal syndrome, MELD score, Macronodule, Micronodule, Reversibility, Spontaneous bacterial peritonitis",

author = "Terumi Takahara and Masaki Iwai and Tsui, {Wilson M.S.}",

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AU - Takahara, Terumi

AU - Iwai, Masaki

AU - Tsui, Wilson M.S.

N1 - Publisher Copyright: © Springer Nature Singapore Pte Ltd. 2019.

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Liver cirrhosis is anatomically defined as a diffuse disruption of the normal architecture of the liver with fibrosis and nodule formation. It is the end result of fibrogenesis caused by chronic liver injury. The anatomical architecture is the same with any etiology: continuous inflammation or hepatocyte damage causes fibrogenesis, and fibers extend from central or portal area, and finally fibrous septa is completely formed to surround regenerative nodules. Thus liver cirrhosis is characterized with hepatocyte dysfunction and portal hypertension.

AB - Liver cirrhosis is anatomically defined as a diffuse disruption of the normal architecture of the liver with fibrosis and nodule formation. It is the end result of fibrogenesis caused by chronic liver injury. The anatomical architecture is the same with any etiology: continuous inflammation or hepatocyte damage causes fibrogenesis, and fibers extend from central or portal area, and finally fibrous septa is completely formed to surround regenerative nodules. Thus liver cirrhosis is characterized with hepatocyte dysfunction and portal hypertension.

KW - Child-Pugh classification

KW - Elastography

KW - Fibrogenesis

KW - Hepatic stellate cell

KW - Hepatorenal syndrome

KW - MELD score

KW - Macronodule

KW - Micronodule

KW - Reversibility

KW - Spontaneous bacterial peritonitis

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SN - 9789811368059

SP - 61

EP - 73

BT - Diagnosis of Liver Disease, Second Edition

PB - Springer Singapore

ER -

Liver Cirrhosis

Abstract

Keywords

ASJC Scopus subject areas

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