Intravenous cyclophosphamide treatment for systemic lupus erythematosus with severe autonomic disorders confirmed by head-up tilt table test: A case series

Masataka Umeda; Hiroaki Kawano; Yushiro Endo; Ayuko Takatani; Tomohiro Koga; Kunihiro Ichinose; Hideki Nakamura; Akihiro Mukaino; Osamu Higuchi; Shunya Nakane; Takahiro Maeda; Atsushi Kawakami

doi:10.1093/mrcr/rxab027

Intravenous cyclophosphamide treatment for systemic lupus erythematosus with severe autonomic disorders confirmed by head-up tilt table test: A case series

Masataka Umeda^*, Hiroaki Kawano, Yushiro Endo, Ayuko Takatani, Tomohiro Koga, Kunihiro Ichinose, Hideki Nakamura, Akihiro Mukaino, Osamu Higuchi, Shunya Nakane, Takahiro Maeda, Atsushi Kawakami

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Autonomic disorders are common in patients with systemic lupus erythematosus (SLE), but the therapeutic strategy and methods for evaluating the effects of therapy have not been established. We describe the three cases of SLE patients who developed severe autonomic disorders as demonstrated by the head-up tilt table test (HUT). All three patients were treated by intensive immunosuppressive treatments including intravenous cyclophosphamide (IVCY); their HUT results all became negative. Our cases suggest that IVCY treatment can be a good therapeutic option for severe autonomic disorders in SLE patients. The HUT is a useful objective method for the diagnosis of and the evaluation of longitudinal therapeutic effects on autonomic disorders in SLE patients with orthostatic intolerance.

Original language	English
Pages (from-to)	47-51
Number of pages	5
Journal	Modern Rheumatology Case Reports
Volume	6
Issue number	1
DOIs	https://doi.org/10.1093/mrcr/rxab027
State	Published - 2022/01/01

Keywords

Autonomic disorder
Cyclophosphamide
Head-up tilt table test
Plasmablasts
Systemic lupus erythematosus

ASJC Scopus subject areas

Rheumatology

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10.1093/mrcr/rxab027

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Umeda, M., Kawano, H., Endo, Y., Takatani, A., Koga, T., Ichinose, K., Nakamura, H., Mukaino, A., Higuchi, O., Nakane, S., Maeda, T., & Kawakami, A. (2022). Intravenous cyclophosphamide treatment for systemic lupus erythematosus with severe autonomic disorders confirmed by head-up tilt table test: A case series. Modern Rheumatology Case Reports, 6(1), 47-51. https://doi.org/10.1093/mrcr/rxab027

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title = "Intravenous cyclophosphamide treatment for systemic lupus erythematosus with severe autonomic disorders confirmed by head-up tilt table test: A case series",

abstract = "Autonomic disorders are common in patients with systemic lupus erythematosus (SLE), but the therapeutic strategy and methods for evaluating the effects of therapy have not been established. We describe the three cases of SLE patients who developed severe autonomic disorders as demonstrated by the head-up tilt table test (HUT). All three patients were treated by intensive immunosuppressive treatments including intravenous cyclophosphamide (IVCY); their HUT results all became negative. Our cases suggest that IVCY treatment can be a good therapeutic option for severe autonomic disorders in SLE patients. The HUT is a useful objective method for the diagnosis of and the evaluation of longitudinal therapeutic effects on autonomic disorders in SLE patients with orthostatic intolerance.",

keywords = "Autonomic disorder, Cyclophosphamide, Head-up tilt table test, Plasmablasts, Systemic lupus erythematosus",

author = "Masataka Umeda and Hiroaki Kawano and Yushiro Endo and Ayuko Takatani and Tomohiro Koga and Kunihiro Ichinose and Hideki Nakamura and Akihiro Mukaino and Osamu Higuchi and Shunya Nakane and Takahiro Maeda and Atsushi Kawakami",

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Umeda, M, Kawano, H, Endo, Y, Takatani, A, Koga, T, Ichinose, K, Nakamura, H, Mukaino, A, Higuchi, O, Nakane, S, Maeda, T & Kawakami, A 2022, 'Intravenous cyclophosphamide treatment for systemic lupus erythematosus with severe autonomic disorders confirmed by head-up tilt table test: A case series', Modern Rheumatology Case Reports, vol. 6, no. 1, pp. 47-51. https://doi.org/10.1093/mrcr/rxab027

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AU - Kawano, Hiroaki

AU - Endo, Yushiro

AU - Takatani, Ayuko

AU - Koga, Tomohiro

AU - Ichinose, Kunihiro

AU - Nakamura, Hideki

AU - Mukaino, Akihiro

AU - Higuchi, Osamu

AU - Nakane, Shunya

AU - Maeda, Takahiro

AU - Kawakami, Atsushi

PY - 2022/1/1

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N2 - Autonomic disorders are common in patients with systemic lupus erythematosus (SLE), but the therapeutic strategy and methods for evaluating the effects of therapy have not been established. We describe the three cases of SLE patients who developed severe autonomic disorders as demonstrated by the head-up tilt table test (HUT). All three patients were treated by intensive immunosuppressive treatments including intravenous cyclophosphamide (IVCY); their HUT results all became negative. Our cases suggest that IVCY treatment can be a good therapeutic option for severe autonomic disorders in SLE patients. The HUT is a useful objective method for the diagnosis of and the evaluation of longitudinal therapeutic effects on autonomic disorders in SLE patients with orthostatic intolerance.

AB - Autonomic disorders are common in patients with systemic lupus erythematosus (SLE), but the therapeutic strategy and methods for evaluating the effects of therapy have not been established. We describe the three cases of SLE patients who developed severe autonomic disorders as demonstrated by the head-up tilt table test (HUT). All three patients were treated by intensive immunosuppressive treatments including intravenous cyclophosphamide (IVCY); their HUT results all became negative. Our cases suggest that IVCY treatment can be a good therapeutic option for severe autonomic disorders in SLE patients. The HUT is a useful objective method for the diagnosis of and the evaluation of longitudinal therapeutic effects on autonomic disorders in SLE patients with orthostatic intolerance.

KW - Autonomic disorder

KW - Cyclophosphamide

KW - Head-up tilt table test

KW - Plasmablasts

KW - Systemic lupus erythematosus

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DO - 10.1093/mrcr/rxab027

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Intravenous cyclophosphamide treatment for systemic lupus erythematosus with severe autonomic disorders confirmed by head-up tilt table test: A case series

Abstract

Keywords

ASJC Scopus subject areas

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