In vitro cytotoxicity of the synthesized gallic acid derivatives (N-Alkyl Gallamide) against breast MCF-7 cancer cells

Maurin Marcelia; Ade Arsianti; Jilly Octaria Tagore Chan; STEv ANO JULIO Wijoyo; Fadilah Fadilah; Rista Putrianingsih; Norma Nur Azizah; Anton Bahtiar; Hiroki Tanimoto; Kiyomikakiuchi

doi:10.13005/ojc/340506

In vitro cytotoxicity of the synthesized gallic acid derivatives (N-Alkyl Gallamide) against breast MCF-7 cancer cells

Maurin Marcelia, Ade Arsianti^*, Jilly Octaria Tagore Chan, STEv ANO JULIO Wijoyo, Fadilah Fadilah, Rista Putrianingsih, Norma Nur Azizah, Anton Bahtiar, Hiroki Tanimoto, Kiyomikakiuchi

^*Corresponding author for this work

Biorecognition Chemistry

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Gallic acid is a phenolic compound distributed in plants and fruits which has been reported to have cytotoxic effect on MCF-7 breast cancer cell line. In this research, we investigated in vitro cytotoxic effect of six synthesized compounds of gallic acid derivatives (N-alkyl gallamide), namely N-methyl gallamide (2); N-ethyl gallamide (3); N-butyl gallamide (4); N-sec-butyl gallamide (5); N-tert-butyl gallamide (6) and N-hexyl gallamide (7) against breast MCF-7 cells by MTT assay. Linear regression analysis is utilized to analyze data to regenerate IC₅₀ value. The results will be compared with gallic acid as an original compound and doxorubicin as a positive control. Among six synthesized compounds, N-tert-butyl gallamide (6) with IC₅₀ value of 2.1 µg/mL, and N-hexyl gallamide (7) with IC₅₀ value of 3.5µg/mL,showed the stronger cytotoxicity against breast MCF-7 cells compared to gallic acid and doxorubicin. Thus,N-tert-butyl gallamide (6) and N-hexyl gallamide (7) are potential to be further developed as a promising anti-breast cancer agents.

Original language	English
Pages (from-to)	2268-2272
Number of pages	5
Journal	Oriental Journal of Chemistry
Volume	34
Issue number	5
DOIs	https://doi.org/10.13005/ojc/340506
State	Published - 2018

Keywords

Breast MCF-7 cells
Cytotoxicity
Gallic acid derivative
MTT assay
N-alkyl gallamide

ASJC Scopus subject areas

General Chemistry
Biochemistry
Environmental Chemistry
Drug Discovery

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.13005/ojc/340506

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Marcelia, M., Arsianti, A., Chan, J. O. T., Wijoyo, STE. ANO. JULIO., Fadilah, F., Putrianingsih, R., Azizah, N. N., Bahtiar, A., Tanimoto, H., & Kiyomikakiuchi (2018). In vitro cytotoxicity of the synthesized gallic acid derivatives (N-Alkyl Gallamide) against breast MCF-7 cancer cells. Oriental Journal of Chemistry, 34(5), 2268-2272. https://doi.org/10.13005/ojc/340506

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title = "In vitro cytotoxicity of the synthesized gallic acid derivatives (N-Alkyl Gallamide) against breast MCF-7 cancer cells",

abstract = "Gallic acid is a phenolic compound distributed in plants and fruits which has been reported to have cytotoxic effect on MCF-7 breast cancer cell line. In this research, we investigated in vitro cytotoxic effect of six synthesized compounds of gallic acid derivatives (N-alkyl gallamide), namely N-methyl gallamide (2); N-ethyl gallamide (3); N-butyl gallamide (4); N-sec-butyl gallamide (5); N-tert-butyl gallamide (6) and N-hexyl gallamide (7) against breast MCF-7 cells by MTT assay. Linear regression analysis is utilized to analyze data to regenerate IC50 value. The results will be compared with gallic acid as an original compound and doxorubicin as a positive control. Among six synthesized compounds, N-tert-butyl gallamide (6) with IC50 value of 2.1 µg/mL, and N-hexyl gallamide (7) with IC50 value of 3.5µg/mL,showed the stronger cytotoxicity against breast MCF-7 cells compared to gallic acid and doxorubicin. Thus,N-tert-butyl gallamide (6) and N-hexyl gallamide (7) are potential to be further developed as a promising anti-breast cancer agents.",

keywords = "Breast MCF-7 cells, Cytotoxicity, Gallic acid derivative, MTT assay, N-alkyl gallamide",

author = "Maurin Marcelia and Ade Arsianti and Chan, {Jilly Octaria Tagore} and Wijoyo, {STEv ANO JULIO} and Fadilah Fadilah and Rista Putrianingsih and Azizah, {Norma Nur} and Anton Bahtiar and Hiroki Tanimoto and Kiyomikakiuchi",

year = "2018",

doi = "10.13005/ojc/340506",

language = "英語",

volume = "34",

pages = "2268--2272",

journal = "Oriental Journal of Chemistry",

issn = "0970-020X",

publisher = "Bhopal, S.A. Iqbal",

number = "5",

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TY - JOUR

T1 - In vitro cytotoxicity of the synthesized gallic acid derivatives (N-Alkyl Gallamide) against breast MCF-7 cancer cells

AU - Marcelia, Maurin

AU - Arsianti, Ade

AU - Chan, Jilly Octaria Tagore

AU - Wijoyo, STEv ANO JULIO

AU - Fadilah, Fadilah

AU - Putrianingsih, Rista

AU - Azizah, Norma Nur

AU - Bahtiar, Anton

AU - Tanimoto, Hiroki

AU - Kiyomikakiuchi,

PY - 2018

Y1 - 2018

N2 - Gallic acid is a phenolic compound distributed in plants and fruits which has been reported to have cytotoxic effect on MCF-7 breast cancer cell line. In this research, we investigated in vitro cytotoxic effect of six synthesized compounds of gallic acid derivatives (N-alkyl gallamide), namely N-methyl gallamide (2); N-ethyl gallamide (3); N-butyl gallamide (4); N-sec-butyl gallamide (5); N-tert-butyl gallamide (6) and N-hexyl gallamide (7) against breast MCF-7 cells by MTT assay. Linear regression analysis is utilized to analyze data to regenerate IC50 value. The results will be compared with gallic acid as an original compound and doxorubicin as a positive control. Among six synthesized compounds, N-tert-butyl gallamide (6) with IC50 value of 2.1 µg/mL, and N-hexyl gallamide (7) with IC50 value of 3.5µg/mL,showed the stronger cytotoxicity against breast MCF-7 cells compared to gallic acid and doxorubicin. Thus,N-tert-butyl gallamide (6) and N-hexyl gallamide (7) are potential to be further developed as a promising anti-breast cancer agents.

AB - Gallic acid is a phenolic compound distributed in plants and fruits which has been reported to have cytotoxic effect on MCF-7 breast cancer cell line. In this research, we investigated in vitro cytotoxic effect of six synthesized compounds of gallic acid derivatives (N-alkyl gallamide), namely N-methyl gallamide (2); N-ethyl gallamide (3); N-butyl gallamide (4); N-sec-butyl gallamide (5); N-tert-butyl gallamide (6) and N-hexyl gallamide (7) against breast MCF-7 cells by MTT assay. Linear regression analysis is utilized to analyze data to regenerate IC50 value. The results will be compared with gallic acid as an original compound and doxorubicin as a positive control. Among six synthesized compounds, N-tert-butyl gallamide (6) with IC50 value of 2.1 µg/mL, and N-hexyl gallamide (7) with IC50 value of 3.5µg/mL,showed the stronger cytotoxicity against breast MCF-7 cells compared to gallic acid and doxorubicin. Thus,N-tert-butyl gallamide (6) and N-hexyl gallamide (7) are potential to be further developed as a promising anti-breast cancer agents.

KW - Breast MCF-7 cells

KW - Cytotoxicity

KW - Gallic acid derivative

KW - MTT assay

KW - N-alkyl gallamide

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U2 - 10.13005/ojc/340506

DO - 10.13005/ojc/340506

M3 - 学術論文

AN - SCOPUS:85055886007

SN - 0970-020X

VL - 34

SP - 2268

EP - 2272

JO - Oriental Journal of Chemistry

JF - Oriental Journal of Chemistry

IS - 5

ER -

In vitro cytotoxicity of the synthesized gallic acid derivatives (N-Alkyl Gallamide) against breast MCF-7 cancer cells

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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