IgA nephropathy with dominant IgA2 deposition accompanied by mantle cell lymphoma

Kota Kakeshita, Tsutomu Koike, Teruhiko Imamura*, Akinori Wada, Shiori Kobayashi, Hayato Fujioka, Hidenori Yamazaki, Koichiro Kinugawa

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Malignant lymphoma is rarely complicated by secondary IgA nephropathy. We encountered a 74-year-old man with rapidly progressive glomerulonephritis due to IgA nephropathy with predominant deposition of IgA 2, instead of IgA1, in the glomerulus that was eventually diagnosed as secondary IgA nephropathy due to mantle cell lymphoma. Renal impairment was improved by chemotherapy for the mantle cell lymphoma. IgA came from the colonic mucosa that was stimulated by the infiltrated lymphoma cells, instead of the tumor itself. We should consider mantle cell lymphoma as a cause of secondary IgA nephropathy, although its prevalence may not be very high.

Original languageEnglish
Pages (from-to)1243-1250
Number of pages8
JournalInternal Medicine
Volume60
Issue number8
DOIs
StatePublished - 2021

Keywords

  • IgA subclass
  • Rapidly progressive glomerulonephritis
  • Renal infiltration

ASJC Scopus subject areas

  • Internal Medicine

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